| Full name: McKusick-Kaufman syndrome | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 20p12.2 | ||
| Entrez ID: 8195 | HGNC ID: HGNC:7108 | Ensembl Gene: ENSG00000125863 | OMIM ID: 604896 |
| Drug and gene relationship at DGIdb | |||
Expression of MKKS:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MKKS | 8195 | 222530_s_at | -0.0894 | 0.9347 | |
| GSE20347 | MKKS | 8195 | 218138_at | 0.4487 | 0.0060 | |
| GSE23400 | MKKS | 8195 | 218138_at | 0.2874 | 0.0004 | |
| GSE26886 | MKKS | 8195 | 222530_s_at | -0.8175 | 0.0000 | |
| GSE29001 | MKKS | 8195 | 218138_at | 0.5599 | 0.1357 | |
| GSE38129 | MKKS | 8195 | 218138_at | 0.3567 | 0.0057 | |
| GSE45670 | MKKS | 8195 | 222530_s_at | 0.2009 | 0.3102 | |
| GSE53622 | MKKS | 8195 | 159199 | -0.0201 | 0.8086 | |
| GSE53624 | MKKS | 8195 | 159199 | -0.0109 | 0.8773 | |
| GSE63941 | MKKS | 8195 | 222530_s_at | 0.8671 | 0.1227 | |
| GSE77861 | MKKS | 8195 | 222530_s_at | -0.2088 | 0.3754 | |
| GSE97050 | MKKS | 8195 | A_33_P3388135 | 0.1976 | 0.6676 | |
| SRP007169 | MKKS | 8195 | RNAseq | 0.0404 | 0.9408 | |
| SRP008496 | MKKS | 8195 | RNAseq | -0.0401 | 0.8952 | |
| SRP064894 | MKKS | 8195 | RNAseq | 0.1709 | 0.3543 | |
| SRP133303 | MKKS | 8195 | RNAseq | 0.2091 | 0.0675 | |
| SRP159526 | MKKS | 8195 | RNAseq | 0.3781 | 0.0534 | |
| SRP193095 | MKKS | 8195 | RNAseq | -0.1330 | 0.2911 | |
| SRP219564 | MKKS | 8195 | RNAseq | -0.0441 | 0.8564 | |
| TCGA | MKKS | 8195 | RNAseq | 0.0073 | 0.8856 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by MKKS expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MKKS:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MKKS | 8195 | 10 | 1 | 19 | |
| GSE20123 | MKKS | 8195 | 10 | 1 | 19 | |
| GSE43470 | MKKS | 8195 | 11 | 1 | 31 | |
| GSE46452 | MKKS | 8195 | 26 | 1 | 32 | |
| GSE47630 | MKKS | 8195 | 18 | 4 | 18 | |
| GSE54993 | MKKS | 8195 | 1 | 14 | 55 | |
| GSE54994 | MKKS | 8195 | 25 | 1 | 27 | |
| GSE60625 | MKKS | 8195 | 0 | 0 | 11 | |
| GSE74703 | MKKS | 8195 | 8 | 1 | 27 | |
| GSE74704 | MKKS | 8195 | 5 | 1 | 14 | |
| TCGA | MKKS | 8195 | 42 | 10 | 44 |
Total number of gains: 156; Total number of losses: 35; Total Number of normals: 297.
Somatic mutations of MKKS:
Generating mutation plots.
Highly correlated genes for MKKS:
Showing top 20/377 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MKKS | FRMD6 | 0.80411 | 3 | 0 | 3 |
| MKKS | PGM2 | 0.797125 | 3 | 0 | 3 |
| MKKS | ACTR3 | 0.751993 | 3 | 0 | 3 |
| MKKS | LAPTM4A | 0.750413 | 3 | 0 | 3 |
| MKKS | ZDHHC6 | 0.746654 | 3 | 0 | 3 |
| MKKS | MAP4K5 | 0.739409 | 3 | 0 | 3 |
| MKKS | RBX1 | 0.738198 | 3 | 0 | 3 |
| MKKS | PCTP | 0.729661 | 3 | 0 | 3 |
| MKKS | GET4 | 0.729421 | 3 | 0 | 3 |
| MKKS | PRPF38A | 0.726839 | 4 | 0 | 4 |
| MKKS | HINT3 | 0.723287 | 3 | 0 | 3 |
| MKKS | PRPSAP1 | 0.719806 | 3 | 0 | 3 |
| MKKS | ANAPC7 | 0.719756 | 3 | 0 | 3 |
| MKKS | LAMTOR3 | 0.716917 | 4 | 0 | 4 |
| MKKS | RFK | 0.713739 | 3 | 0 | 3 |
| MKKS | HDHD2 | 0.71188 | 3 | 0 | 3 |
| MKKS | RIOK2 | 0.711288 | 3 | 0 | 3 |
| MKKS | KIN | 0.709714 | 3 | 0 | 3 |
| MKKS | SUCLG1 | 0.698884 | 4 | 0 | 3 |
| MKKS | EPG5 | 0.69499 | 3 | 0 | 3 |
For details and further investigation, click here
