| Full name: ligand of numb-protein X 2 | Alias Symbol: MGC46315 | ||
| Type: protein-coding gene | Cytoband: 13q12.2 | ||
| Entrez ID: 222484 | HGNC ID: HGNC:20421 | Ensembl Gene: ENSG00000139517 | OMIM ID: 609733 |
| Drug and gene relationship at DGIdb | |||
Expression of LNX2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LNX2 | 222484 | 227569_at | -0.3025 | 0.7000 | |
| GSE26886 | LNX2 | 222484 | 227569_at | -0.5865 | 0.0023 | |
| GSE45670 | LNX2 | 222484 | 227569_at | -0.1420 | 0.4095 | |
| GSE53622 | LNX2 | 222484 | 3941 | -0.5706 | 0.0000 | |
| GSE53624 | LNX2 | 222484 | 3941 | -0.9381 | 0.0000 | |
| GSE63941 | LNX2 | 222484 | 227569_at | 0.3465 | 0.3328 | |
| GSE77861 | LNX2 | 222484 | 227569_at | -0.3721 | 0.2600 | |
| GSE97050 | LNX2 | 222484 | A_23_P402287 | -0.1336 | 0.5666 | |
| SRP007169 | LNX2 | 222484 | RNAseq | -1.6547 | 0.0001 | |
| SRP008496 | LNX2 | 222484 | RNAseq | -1.4908 | 0.0000 | |
| SRP064894 | LNX2 | 222484 | RNAseq | -1.1130 | 0.0000 | |
| SRP133303 | LNX2 | 222484 | RNAseq | -0.0738 | 0.7450 | |
| SRP159526 | LNX2 | 222484 | RNAseq | -0.7660 | 0.0731 | |
| SRP193095 | LNX2 | 222484 | RNAseq | -0.8105 | 0.0000 | |
| SRP219564 | LNX2 | 222484 | RNAseq | -1.2777 | 0.0005 | |
| TCGA | LNX2 | 222484 | RNAseq | -0.1852 | 0.0018 |
Upregulated datasets: 0; Downregulated datasets: 4.
Survival by LNX2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LNX2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LNX2 | 222484 | 1 | 13 | 16 | |
| GSE20123 | LNX2 | 222484 | 1 | 12 | 17 | |
| GSE43470 | LNX2 | 222484 | 2 | 12 | 29 | |
| GSE46452 | LNX2 | 222484 | 0 | 33 | 26 | |
| GSE47630 | LNX2 | 222484 | 3 | 26 | 11 | |
| GSE54993 | LNX2 | 222484 | 11 | 2 | 57 | |
| GSE54994 | LNX2 | 222484 | 1 | 13 | 39 | |
| GSE60625 | LNX2 | 222484 | 0 | 3 | 8 | |
| GSE74703 | LNX2 | 222484 | 2 | 9 | 25 | |
| GSE74704 | LNX2 | 222484 | 0 | 10 | 10 | |
| TCGA | LNX2 | 222484 | 6 | 41 | 49 |
Total number of gains: 27; Total number of losses: 174; Total Number of normals: 287.
Somatic mutations of LNX2:
Generating mutation plots.
Highly correlated genes for LNX2:
Showing top 20/937 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LNX2 | NCKAP1 | 0.790437 | 3 | 0 | 3 |
| LNX2 | MAP4K5 | 0.787547 | 3 | 0 | 3 |
| LNX2 | HBP1 | 0.776926 | 3 | 0 | 3 |
| LNX2 | RHBDF1 | 0.735797 | 3 | 0 | 3 |
| LNX2 | MTA3 | 0.731024 | 4 | 0 | 4 |
| LNX2 | CRBN | 0.722671 | 3 | 0 | 3 |
| LNX2 | NUDCD3 | 0.721406 | 3 | 0 | 3 |
| LNX2 | FAM8A1 | 0.714097 | 3 | 0 | 3 |
| LNX2 | NLRX1 | 0.70748 | 4 | 0 | 4 |
| LNX2 | ZCCHC8 | 0.705459 | 3 | 0 | 3 |
| LNX2 | KDM5B | 0.69815 | 3 | 0 | 3 |
| LNX2 | SENP7 | 0.695075 | 3 | 0 | 3 |
| LNX2 | TALDO1 | 0.693781 | 3 | 0 | 3 |
| LNX2 | BARD1 | 0.692035 | 4 | 0 | 3 |
| LNX2 | ACSL3 | 0.69027 | 4 | 0 | 3 |
| LNX2 | LTN1 | 0.688408 | 4 | 0 | 4 |
| LNX2 | FBXW11 | 0.686033 | 5 | 0 | 4 |
| LNX2 | USP54 | 0.68602 | 4 | 0 | 4 |
| LNX2 | SPPL3 | 0.685367 | 4 | 0 | 3 |
| LNX2 | LYSMD3 | 0.682575 | 4 | 0 | 3 |
For details and further investigation, click here
