| Full name: protein phosphatase 4 regulatory subunit 2 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 3p13 | ||
| Entrez ID: 151987 | HGNC ID: HGNC:18296 | Ensembl Gene: ENSG00000163605 | OMIM ID: 613822 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of PPP4R2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PPP4R2 | 151987 | 225519_at | 0.1192 | 0.8262 | |
| GSE20347 | PPP4R2 | 151987 | 220764_at | -0.3029 | 0.0013 | |
| GSE23400 | PPP4R2 | 151987 | 220764_at | -0.1294 | 0.0000 | |
| GSE26886 | PPP4R2 | 151987 | 225519_at | -1.0444 | 0.0001 | |
| GSE29001 | PPP4R2 | 151987 | 220764_at | -0.3774 | 0.0517 | |
| GSE38129 | PPP4R2 | 151987 | 220764_at | -0.2129 | 0.0028 | |
| GSE45670 | PPP4R2 | 151987 | 225519_at | -0.0062 | 0.9673 | |
| GSE53622 | PPP4R2 | 151987 | 30367 | -0.1071 | 0.0280 | |
| GSE53624 | PPP4R2 | 151987 | 30367 | -0.2959 | 0.0000 | |
| GSE63941 | PPP4R2 | 151987 | 225519_at | -0.9756 | 0.0445 | |
| GSE77861 | PPP4R2 | 151987 | 225519_at | -0.4345 | 0.1881 | |
| GSE97050 | PPP4R2 | 151987 | A_32_P228775 | 0.0031 | 0.9935 | |
| SRP007169 | PPP4R2 | 151987 | RNAseq | -0.2883 | 0.4384 | |
| SRP008496 | PPP4R2 | 151987 | RNAseq | 0.2844 | 0.3596 | |
| SRP064894 | PPP4R2 | 151987 | RNAseq | -0.3166 | 0.0693 | |
| SRP133303 | PPP4R2 | 151987 | RNAseq | -0.1293 | 0.2364 | |
| SRP159526 | PPP4R2 | 151987 | RNAseq | 0.1953 | 0.5393 | |
| SRP193095 | PPP4R2 | 151987 | RNAseq | -0.4014 | 0.0000 | |
| SRP219564 | PPP4R2 | 151987 | RNAseq | -0.3596 | 0.2509 | |
| TCGA | PPP4R2 | 151987 | RNAseq | -0.0964 | 0.0956 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by PPP4R2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PPP4R2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PPP4R2 | 151987 | 1 | 20 | 9 | |
| GSE20123 | PPP4R2 | 151987 | 1 | 20 | 9 | |
| GSE43470 | PPP4R2 | 151987 | 0 | 21 | 22 | |
| GSE46452 | PPP4R2 | 151987 | 2 | 17 | 40 | |
| GSE47630 | PPP4R2 | 151987 | 1 | 23 | 16 | |
| GSE54993 | PPP4R2 | 151987 | 4 | 3 | 63 | |
| GSE54994 | PPP4R2 | 151987 | 1 | 31 | 21 | |
| GSE60625 | PPP4R2 | 151987 | 3 | 1 | 7 | |
| GSE74703 | PPP4R2 | 151987 | 0 | 17 | 19 | |
| GSE74704 | PPP4R2 | 151987 | 1 | 13 | 6 | |
| TCGA | PPP4R2 | 151987 | 1 | 79 | 16 |
Total number of gains: 15; Total number of losses: 245; Total Number of normals: 228.
Somatic mutations of PPP4R2:
Generating mutation plots.
Highly correlated genes for PPP4R2:
Showing top 20/745 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PPP4R2 | MAP4K5 | 0.87884 | 3 | 0 | 3 |
| PPP4R2 | GRPEL1 | 0.815292 | 3 | 0 | 3 |
| PPP4R2 | UBE2E2 | 0.812447 | 3 | 0 | 3 |
| PPP4R2 | NANS | 0.79489 | 3 | 0 | 3 |
| PPP4R2 | RNF149 | 0.792938 | 3 | 0 | 3 |
| PPP4R2 | MAP3K8 | 0.778474 | 3 | 0 | 3 |
| PPP4R2 | FRMD6 | 0.770505 | 3 | 0 | 3 |
| PPP4R2 | ZNF394 | 0.767361 | 3 | 0 | 3 |
| PPP4R2 | WIPF2 | 0.766129 | 3 | 0 | 3 |
| PPP4R2 | SERTAD2 | 0.75139 | 3 | 0 | 3 |
| PPP4R2 | LPIN2 | 0.74641 | 4 | 0 | 4 |
| PPP4R2 | RPP40 | 0.745908 | 3 | 0 | 3 |
| PPP4R2 | STYX | 0.745126 | 3 | 0 | 3 |
| PPP4R2 | ADCY7 | 0.743123 | 3 | 0 | 3 |
| PPP4R2 | TSEN2 | 0.735209 | 4 | 0 | 4 |
| PPP4R2 | ZNF436 | 0.734963 | 3 | 0 | 3 |
| PPP4R2 | CRK | 0.734535 | 3 | 0 | 3 |
| PPP4R2 | ALKBH3 | 0.733043 | 3 | 0 | 3 |
| PPP4R2 | MRPL1 | 0.730877 | 3 | 0 | 3 |
| PPP4R2 | TMEM167A | 0.72798 | 3 | 0 | 3 |
For details and further investigation, click here
