| Full name: WD repeat domain, phosphoinositide interacting 2 | Alias Symbol: ATG21|CGI-50|FLJ12979|FLJ14217|FLJ42984|DKFZP434J154|DKFZp686P02188|ATG18B | ||
| Type: protein-coding gene | Cytoband: 7p22.1 | ||
| Entrez ID: 26100 | HGNC ID: HGNC:32225 | Ensembl Gene: ENSG00000157954 | OMIM ID: 609225 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of WIPI2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | WIPI2 | 26100 | 204710_s_at | 0.1499 | 0.6768 | |
| GSE20347 | WIPI2 | 26100 | 204710_s_at | -0.0791 | 0.5529 | |
| GSE23400 | WIPI2 | 26100 | 204710_s_at | -0.0543 | 0.4800 | |
| GSE26886 | WIPI2 | 26100 | 202031_s_at | 0.3249 | 0.2141 | |
| GSE29001 | WIPI2 | 26100 | 202031_s_at | 0.1426 | 0.4283 | |
| GSE38129 | WIPI2 | 26100 | 204710_s_at | 0.1107 | 0.4392 | |
| GSE45670 | WIPI2 | 26100 | 204710_s_at | -0.0608 | 0.6765 | |
| GSE53622 | WIPI2 | 26100 | 11896 | -0.1023 | 0.0321 | |
| GSE53624 | WIPI2 | 26100 | 11896 | -0.0176 | 0.7318 | |
| GSE63941 | WIPI2 | 26100 | 204710_s_at | 0.0658 | 0.8756 | |
| GSE77861 | WIPI2 | 26100 | 204710_s_at | 0.0183 | 0.9387 | |
| GSE97050 | WIPI2 | 26100 | A_33_P3356607 | 0.0788 | 0.7628 | |
| SRP007169 | WIPI2 | 26100 | RNAseq | -1.4535 | 0.0007 | |
| SRP008496 | WIPI2 | 26100 | RNAseq | -1.0279 | 0.0000 | |
| SRP064894 | WIPI2 | 26100 | RNAseq | 0.0173 | 0.9260 | |
| SRP133303 | WIPI2 | 26100 | RNAseq | 0.0629 | 0.7121 | |
| SRP159526 | WIPI2 | 26100 | RNAseq | 0.0628 | 0.7818 | |
| SRP193095 | WIPI2 | 26100 | RNAseq | -0.0758 | 0.6253 | |
| SRP219564 | WIPI2 | 26100 | RNAseq | 0.0645 | 0.8646 | |
| TCGA | WIPI2 | 26100 | RNAseq | 0.0199 | 0.6652 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by WIPI2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of WIPI2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | WIPI2 | 26100 | 14 | 1 | 15 | |
| GSE20123 | WIPI2 | 26100 | 14 | 1 | 15 | |
| GSE43470 | WIPI2 | 26100 | 6 | 1 | 36 | |
| GSE46452 | WIPI2 | 26100 | 13 | 1 | 45 | |
| GSE47630 | WIPI2 | 26100 | 9 | 1 | 30 | |
| GSE54993 | WIPI2 | 26100 | 0 | 6 | 64 | |
| GSE54994 | WIPI2 | 26100 | 23 | 1 | 29 | |
| GSE60625 | WIPI2 | 26100 | 0 | 0 | 11 | |
| GSE74703 | WIPI2 | 26100 | 6 | 0 | 30 | |
| GSE74704 | WIPI2 | 26100 | 9 | 0 | 11 | |
| TCGA | WIPI2 | 26100 | 56 | 5 | 35 |
Total number of gains: 150; Total number of losses: 17; Total Number of normals: 321.
Somatic mutations of WIPI2:
Generating mutation plots.
Highly correlated genes for WIPI2:
Showing top 20/161 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| WIPI2 | MAP4K5 | 0.787333 | 3 | 0 | 3 |
| WIPI2 | MTHFD1 | 0.777664 | 3 | 0 | 3 |
| WIPI2 | RNF114 | 0.743035 | 3 | 0 | 3 |
| WIPI2 | PAK1IP1 | 0.74096 | 3 | 0 | 3 |
| WIPI2 | MAP3K13 | 0.727529 | 3 | 0 | 3 |
| WIPI2 | STK35 | 0.725443 | 3 | 0 | 3 |
| WIPI2 | DICER1 | 0.724264 | 4 | 0 | 4 |
| WIPI2 | NIPBL | 0.723088 | 3 | 0 | 3 |
| WIPI2 | SLC35A2 | 0.721973 | 3 | 0 | 3 |
| WIPI2 | UNG | 0.718343 | 3 | 0 | 3 |
| WIPI2 | CDK5RAP1 | 0.717946 | 3 | 0 | 3 |
| WIPI2 | THEM4 | 0.717051 | 4 | 0 | 4 |
| WIPI2 | TRMT6 | 0.713935 | 3 | 0 | 3 |
| WIPI2 | SNW1 | 0.70966 | 3 | 0 | 3 |
| WIPI2 | COIL | 0.707184 | 3 | 0 | 3 |
| WIPI2 | C1orf74 | 0.706603 | 3 | 0 | 3 |
| WIPI2 | SFR1 | 0.70439 | 3 | 0 | 3 |
| WIPI2 | AGPAT5 | 0.703999 | 3 | 0 | 3 |
| WIPI2 | MAPK8IP3 | 0.69994 | 3 | 0 | 3 |
| WIPI2 | GORASP2 | 0.693745 | 4 | 0 | 4 |
For details and further investigation, click here
