| Full name: spectrin repeat containing nuclear envelope protein 1 | Alias Symbol: SYNE-1B|KIAA0796|8B|Nesprin-1|enaptin|MYNE1|CPG2|dJ45H2.2|SCAR8|ARCA1|Nesp1 | ||
| Type: protein-coding gene | Cytoband: 6q25.2 | ||
| Entrez ID: 23345 | HGNC ID: HGNC:17089 | Ensembl Gene: ENSG00000131018 | OMIM ID: 608441 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of SYNE1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SYNE1 | 23345 | 209447_at | -1.1110 | 0.2544 | |
| GSE20347 | SYNE1 | 23345 | 209447_at | -0.1164 | 0.6351 | |
| GSE23400 | SYNE1 | 23345 | 209447_at | -0.2574 | 0.0631 | |
| GSE26886 | SYNE1 | 23345 | 209447_at | 0.2057 | 0.5654 | |
| GSE29001 | SYNE1 | 23345 | 209447_at | 0.0315 | 0.9343 | |
| GSE38129 | SYNE1 | 23345 | 209447_at | -0.7771 | 0.0176 | |
| GSE45670 | SYNE1 | 23345 | 209447_at | -2.0634 | 0.0000 | |
| GSE53622 | SYNE1 | 23345 | 79445 | -0.8770 | 0.0000 | |
| GSE53624 | SYNE1 | 23345 | 79445 | -0.7180 | 0.0000 | |
| GSE63941 | SYNE1 | 23345 | 209447_at | -4.5239 | 0.0000 | |
| GSE77861 | SYNE1 | 23345 | 244144_at | -0.0686 | 0.4114 | |
| GSE97050 | SYNE1 | 23345 | A_33_P3335920 | -0.4735 | 0.1670 | |
| SRP007169 | SYNE1 | 23345 | RNAseq | 1.2870 | 0.0157 | |
| SRP008496 | SYNE1 | 23345 | RNAseq | 1.4051 | 0.0113 | |
| SRP064894 | SYNE1 | 23345 | RNAseq | -0.4528 | 0.1596 | |
| SRP133303 | SYNE1 | 23345 | RNAseq | -0.7703 | 0.0055 | |
| SRP159526 | SYNE1 | 23345 | RNAseq | -0.7041 | 0.0208 | |
| SRP193095 | SYNE1 | 23345 | RNAseq | 0.2275 | 0.4480 | |
| SRP219564 | SYNE1 | 23345 | RNAseq | -0.2066 | 0.7952 | |
| TCGA | SYNE1 | 23345 | RNAseq | -0.8416 | 0.0000 |
Upregulated datasets: 2; Downregulated datasets: 2.
Survival by SYNE1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SYNE1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SYNE1 | 23345 | 1 | 4 | 25 | |
| GSE20123 | SYNE1 | 23345 | 1 | 3 | 26 | |
| GSE43470 | SYNE1 | 23345 | 4 | 0 | 39 | |
| GSE46452 | SYNE1 | 23345 | 3 | 10 | 46 | |
| GSE47630 | SYNE1 | 23345 | 9 | 4 | 27 | |
| GSE54993 | SYNE1 | 23345 | 3 | 2 | 65 | |
| GSE54994 | SYNE1 | 23345 | 8 | 8 | 37 | |
| GSE60625 | SYNE1 | 23345 | 0 | 1 | 10 | |
| GSE74703 | SYNE1 | 23345 | 4 | 0 | 32 | |
| GSE74704 | SYNE1 | 23345 | 0 | 1 | 19 | |
| TCGA | SYNE1 | 23345 | 10 | 22 | 64 |
Total number of gains: 43; Total number of losses: 55; Total Number of normals: 390.
Somatic mutations of SYNE1:
Generating mutation plots.
Highly correlated genes for SYNE1:
Showing top 20/1262 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SYNE1 | SLC12A4 | 0.827317 | 3 | 0 | 3 |
| SYNE1 | MSRB3 | 0.822396 | 6 | 0 | 6 |
| SYNE1 | USP9Y | 0.814752 | 3 | 0 | 3 |
| SYNE1 | EBF1 | 0.809832 | 7 | 0 | 7 |
| SYNE1 | GRHPR | 0.806231 | 3 | 0 | 3 |
| SYNE1 | LINC01279 | 0.803367 | 4 | 0 | 4 |
| SYNE1 | TBC1D20 | 0.799827 | 3 | 0 | 3 |
| SYNE1 | FIBIN | 0.797387 | 5 | 0 | 4 |
| SYNE1 | TNFSF12 | 0.797127 | 3 | 0 | 3 |
| SYNE1 | MRVI1 | 0.796454 | 7 | 0 | 7 |
| SYNE1 | C1QTNF7 | 0.791095 | 5 | 0 | 5 |
| SYNE1 | LRRN4CL | 0.787024 | 7 | 0 | 7 |
| SYNE1 | PDE5A | 0.784356 | 9 | 0 | 9 |
| SYNE1 | DIXDC1 | 0.782409 | 10 | 0 | 9 |
| SYNE1 | MTRF1L | 0.78148 | 3 | 0 | 3 |
| SYNE1 | ARMC9 | 0.779434 | 4 | 0 | 4 |
| SYNE1 | EMCN | 0.779105 | 5 | 0 | 5 |
| SYNE1 | MGARP | 0.778126 | 3 | 0 | 3 |
| SYNE1 | MEOX2 | 0.777153 | 8 | 0 | 8 |
| SYNE1 | PEG3 | 0.776817 | 7 | 0 | 7 |
For details and further investigation, click here
