| Full name: MDM4 regulator of p53 | Alias Symbol: MDMX|HDMX | ||
| Type: protein-coding gene | Cytoband: 1q32.1 | ||
| Entrez ID: 4194 | HGNC ID: HGNC:6974 | Ensembl Gene: ENSG00000198625 | OMIM ID: 602704 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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MDM4 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04115 | p53 signaling pathway |
Expression of MDM4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MDM4 | 4194 | 236814_at | -0.1437 | 0.8529 | |
| GSE20347 | MDM4 | 4194 | 205655_at | -0.0029 | 0.9632 | |
| GSE23400 | MDM4 | 4194 | 205655_at | 0.0216 | 0.3185 | |
| GSE26886 | MDM4 | 4194 | 236814_at | 1.1488 | 0.0061 | |
| GSE29001 | MDM4 | 4194 | 205655_at | 0.1028 | 0.5876 | |
| GSE38129 | MDM4 | 4194 | 205655_at | -0.0605 | 0.2687 | |
| GSE45670 | MDM4 | 4194 | 236814_at | -0.1031 | 0.6271 | |
| GSE53622 | MDM4 | 4194 | 45820 | -0.0203 | 0.8203 | |
| GSE53624 | MDM4 | 4194 | 1848 | -0.0840 | 0.3986 | |
| GSE63941 | MDM4 | 4194 | 236814_at | 0.8582 | 0.1261 | |
| GSE77861 | MDM4 | 4194 | 236814_at | 0.7549 | 0.0569 | |
| GSE97050 | MDM4 | 4194 | A_33_P3389376 | 0.1097 | 0.6654 | |
| SRP007169 | MDM4 | 4194 | RNAseq | 0.5432 | 0.1581 | |
| SRP008496 | MDM4 | 4194 | RNAseq | 0.5754 | 0.0256 | |
| SRP064894 | MDM4 | 4194 | RNAseq | 0.0006 | 0.9975 | |
| SRP133303 | MDM4 | 4194 | RNAseq | -0.1101 | 0.3889 | |
| SRP159526 | MDM4 | 4194 | RNAseq | 0.1219 | 0.6745 | |
| SRP193095 | MDM4 | 4194 | RNAseq | 0.1448 | 0.1993 | |
| SRP219564 | MDM4 | 4194 | RNAseq | 0.3656 | 0.3395 | |
| TCGA | MDM4 | 4194 | RNAseq | -0.1792 | 0.0020 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by MDM4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MDM4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MDM4 | 4194 | 11 | 0 | 19 | |
| GSE20123 | MDM4 | 4194 | 11 | 0 | 19 | |
| GSE43470 | MDM4 | 4194 | 6 | 0 | 37 | |
| GSE46452 | MDM4 | 4194 | 3 | 1 | 55 | |
| GSE47630 | MDM4 | 4194 | 14 | 0 | 26 | |
| GSE54993 | MDM4 | 4194 | 0 | 6 | 64 | |
| GSE54994 | MDM4 | 4194 | 15 | 0 | 38 | |
| GSE60625 | MDM4 | 4194 | 0 | 0 | 11 | |
| GSE74703 | MDM4 | 4194 | 6 | 0 | 30 | |
| GSE74704 | MDM4 | 4194 | 5 | 0 | 15 | |
| TCGA | MDM4 | 4194 | 44 | 4 | 48 |
Total number of gains: 115; Total number of losses: 11; Total Number of normals: 362.
Somatic mutations of MDM4:
Generating mutation plots.
Highly correlated genes for MDM4:
Showing top 20/374 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MDM4 | AMMECR1L | 0.74751 | 3 | 0 | 3 |
| MDM4 | C1orf131 | 0.743224 | 3 | 0 | 3 |
| MDM4 | GPATCH4 | 0.73119 | 3 | 0 | 3 |
| MDM4 | RRP15 | 0.728055 | 3 | 0 | 3 |
| MDM4 | THOC2 | 0.725099 | 4 | 0 | 4 |
| MDM4 | USP45 | 0.724049 | 3 | 0 | 3 |
| MDM4 | TMEM181 | 0.721851 | 3 | 0 | 3 |
| MDM4 | METTL23 | 0.718385 | 3 | 0 | 3 |
| MDM4 | SFR1 | 0.713507 | 3 | 0 | 3 |
| MDM4 | LARP6 | 0.711203 | 3 | 0 | 3 |
| MDM4 | HNRNPA3 | 0.709544 | 3 | 0 | 3 |
| MDM4 | WDR43 | 0.708514 | 3 | 0 | 3 |
| MDM4 | DDX55 | 0.702659 | 3 | 0 | 3 |
| MDM4 | TIMELESS | 0.701376 | 3 | 0 | 3 |
| MDM4 | THEM4 | 0.693692 | 3 | 0 | 3 |
| MDM4 | DNM1L | 0.691861 | 3 | 0 | 3 |
| MDM4 | CDK5RAP3 | 0.691823 | 3 | 0 | 3 |
| MDM4 | TUG1 | 0.687299 | 3 | 0 | 3 |
| MDM4 | TMEM97 | 0.687097 | 3 | 0 | 3 |
| MDM4 | SMCR8 | 0.686608 | 3 | 0 | 3 |
For details and further investigation, click here
