WDR43

 

Full name: WD repeat domain 43 Alias Symbol: KIAA0007|NET12|UTP5
Type: protein-coding gene Cytoband: 2p23.2
Entrez ID: 23160 HGNC ID: HGNC:28945 Ensembl Gene: ENSG00000163811 OMIM ID: 616195
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of WDR43:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 WDR43 23160 214662_at 0.7642 0.0736
GSE20347 WDR43 23160 214662_at 0.3446 0.0384
GSE23400 WDR43 23160 214662_at 0.5907 0.0000
GSE26886 WDR43 23160 214662_at 1.1675 0.0000
GSE29001 WDR43 23160 214662_at 0.2896 0.3481
GSE38129 WDR43 23160 214662_at 0.5132 0.0018
GSE45670 WDR43 23160 214662_at 0.3587 0.0298
GSE53622 WDR43 23160 45829 0.2735 0.0003
GSE53624 WDR43 23160 45829 0.3730 0.0000
GSE63941 WDR43 23160 214662_at 0.0700 0.8822
GSE77861 WDR43 23160 214662_at 0.5482 0.0232
GSE97050 WDR43 23160 A_23_P344853 0.2992 0.3275
SRP007169 WDR43 23160 RNAseq 0.8052 0.0140
SRP008496 WDR43 23160 RNAseq 0.7999 0.0006
SRP064894 WDR43 23160 RNAseq 0.3451 0.1967
SRP133303 WDR43 23160 RNAseq 0.5209 0.0027
SRP159526 WDR43 23160 RNAseq 0.2718 0.2897
SRP193095 WDR43 23160 RNAseq 0.4029 0.0043
SRP219564 WDR43 23160 RNAseq 0.4210 0.3521
TCGA WDR43 23160 RNAseq 0.2275 0.0000

Upregulated datasets: 1; Downregulated datasets: 0.  

 

Survival by WDR43 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of WDR43:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 WDR43 23160 11 2 17
GSE20123 WDR43 23160 11 2 17
GSE43470 WDR43 23160 3 1 39
GSE46452 WDR43 23160 2 4 53
GSE47630 WDR43 23160 8 0 32
GSE54993 WDR43 23160 0 6 64
GSE54994 WDR43 23160 10 0 43
GSE60625 WDR43 23160 0 3 8
GSE74703 WDR43 23160 3 0 33
GSE74704 WDR43 23160 9 1 10
TCGA WDR43 23160 36 2 58

Total number of gains: 93; Total number of losses: 21; Total Number of normals: 374.  

 

Somatic mutations of WDR43:

 

Generating mutation plots.

 

Highly correlated genes for WDR43:

 

Showing top 20/1386 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
WDR43PPP1R16A0.757268303
WDR43LINGO10.754765303
WDR43LRRCC10.753614303
WDR43SNRNP480.752109303
WDR43TP53I130.743336303
WDR43A4GALT0.738016303
WDR43TRIM50.737987303
WDR43DZIP1L0.735058303
WDR43CEBPZ0.727863909
WDR43ZNF7910.724341303
WDR43TMEM2230.714505605
WDR43CMTM40.713692404
WDR43LRRC580.712172505
WDR43NUP430.710432807
WDR43ZNF1210.708944606
WDR43MDM40.708514303
WDR43PIAS40.708254504
WDR43EME10.70505504
WDR43PRPF40A0.70500611010
WDR43CDCA20.701007505

For details and further investigation, click here