| Full name: methyltransferase like 23 | Alias Symbol: LOC124512 | ||
| Type: protein-coding gene | Cytoband: 17q25.2 | ||
| Entrez ID: 124512 | HGNC ID: HGNC:26988 | Ensembl Gene: ENSG00000181038 | OMIM ID: 615262 |
| Drug and gene relationship at DGIdb | |||
Expression of METTL23:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | METTL23 | 124512 | 225808_at | 0.4144 | 0.0559 | |
| GSE26886 | METTL23 | 124512 | 225808_at | 1.0466 | 0.0000 | |
| GSE45670 | METTL23 | 124512 | 225808_at | 0.2175 | 0.3014 | |
| GSE53622 | METTL23 | 124512 | 130558 | 0.4272 | 0.0000 | |
| GSE53624 | METTL23 | 124512 | 130558 | 0.6195 | 0.0000 | |
| GSE63941 | METTL23 | 124512 | 225808_at | 0.5918 | 0.0482 | |
| GSE77861 | METTL23 | 124512 | 225808_at | 0.4110 | 0.0759 | |
| GSE97050 | METTL23 | A_21_P0000717 | 0.4191 | 0.1726 | ||
| SRP007169 | METTL23 | 124512 | RNAseq | 1.0159 | 0.0434 | |
| SRP008496 | METTL23 | 124512 | RNAseq | 0.9334 | 0.0017 | |
| SRP064894 | METTL23 | 124512 | RNAseq | 0.6188 | 0.0009 | |
| SRP133303 | METTL23 | 124512 | RNAseq | 0.5645 | 0.0096 | |
| SRP159526 | METTL23 | 124512 | RNAseq | 0.5852 | 0.0078 | |
| SRP193095 | METTL23 | 124512 | RNAseq | -0.0040 | 0.9699 | |
| SRP219564 | METTL23 | 124512 | RNAseq | 0.0472 | 0.8842 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by METTL23 expression:
 |  |
| GSE53622 | GSE53624 |
Note: Click image to view full size file.
Copy number change of METTL23:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | METTL23 | 124512 | 7 | 2 | 21 | |
| GSE20123 | METTL23 | 124512 | 7 | 2 | 21 | |
| GSE43470 | METTL23 | 124512 | 4 | 3 | 36 | |
| GSE46452 | METTL23 | 124512 | 33 | 1 | 25 | |
| GSE47630 | METTL23 | 124512 | 8 | 1 | 31 | |
| GSE54993 | METTL23 | 124512 | 2 | 5 | 63 | |
| GSE54994 | METTL23 | 124512 | 10 | 4 | 39 | |
| GSE60625 | METTL23 | 124512 | 6 | 0 | 5 | |
| GSE74703 | METTL23 | 124512 | 4 | 1 | 31 | |
| GSE74704 | METTL23 | 124512 | 5 | 1 | 14 | |
| TCGA | METTL23 | 124512 | 31 | 10 | 55 |
Total number of gains: 117; Total number of losses: 30; Total Number of normals: 341.
Somatic mutations of METTL23:
Generating mutation plots.
Highly correlated genes for METTL23:
Showing top 20/1914 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| METTL23 | SEMA3C | 0.837625 | 3 | 0 | 3 |
| METTL23 | PTPN14 | 0.81684 | 3 | 0 | 3 |
| METTL23 | MMP15 | 0.807341 | 3 | 0 | 3 |
| METTL23 | CPT1A | 0.801716 | 3 | 0 | 3 |
| METTL23 | COG2 | 0.794181 | 6 | 0 | 6 |
| METTL23 | LRRC58 | 0.78207 | 4 | 0 | 4 |
| METTL23 | STK17A | 0.777658 | 3 | 0 | 3 |
| METTL23 | KTI12 | 0.776957 | 3 | 0 | 3 |
| METTL23 | SRSF6 | 0.773121 | 3 | 0 | 3 |
| METTL23 | TRMT61B | 0.770941 | 4 | 0 | 4 |
| METTL23 | PIGL | 0.769219 | 3 | 0 | 3 |
| METTL23 | GAS2L1 | 0.767665 | 3 | 0 | 3 |
| METTL23 | RAVER1 | 0.758946 | 4 | 0 | 4 |
| METTL23 | CNNM3 | 0.756617 | 3 | 0 | 3 |
| METTL23 | DNMT1 | 0.756091 | 7 | 0 | 7 |
| METTL23 | XPO1 | 0.756073 | 6 | 0 | 6 |
| METTL23 | B3GALNT2 | 0.754691 | 3 | 0 | 3 |
| METTL23 | MTERF3 | 0.753157 | 4 | 0 | 4 |
| METTL23 | PET117 | 0.751688 | 4 | 0 | 3 |
| METTL23 | XAB2 | 0.748378 | 3 | 0 | 3 |
For details and further investigation, click here
