| Full name: timeless circadian regulator | Alias Symbol: hTIM|TIM|TIM1 | ||
| Type: protein-coding gene | Cytoband: 12q13.3 | ||
| Entrez ID: 8914 | HGNC ID: HGNC:11813 | Ensembl Gene: ENSG00000111602 | OMIM ID: 603887 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of TIMELESS:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TIMELESS | 8914 | 203046_s_at | 1.3192 | 0.0333 | |
| GSE20347 | TIMELESS | 8914 | 203046_s_at | 1.2824 | 0.0000 | |
| GSE23400 | TIMELESS | 8914 | 203046_s_at | 0.9585 | 0.0000 | |
| GSE26886 | TIMELESS | 8914 | 203046_s_at | 0.8019 | 0.0027 | |
| GSE29001 | TIMELESS | 8914 | 203046_s_at | 1.1724 | 0.0000 | |
| GSE38129 | TIMELESS | 8914 | 203046_s_at | 1.6027 | 0.0000 | |
| GSE45670 | TIMELESS | 8914 | 203046_s_at | 1.1992 | 0.0000 | |
| GSE53622 | TIMELESS | 8914 | 31790 | 1.1799 | 0.0000 | |
| GSE53624 | TIMELESS | 8914 | 31790 | 1.5366 | 0.0000 | |
| GSE63941 | TIMELESS | 8914 | 203046_s_at | 1.7193 | 0.0019 | |
| GSE77861 | TIMELESS | 8914 | 203046_s_at | 1.0816 | 0.0011 | |
| GSE97050 | TIMELESS | 8914 | A_23_P53276 | 0.6395 | 0.1922 | |
| SRP007169 | TIMELESS | 8914 | RNAseq | 2.6216 | 0.0000 | |
| SRP008496 | TIMELESS | 8914 | RNAseq | 2.0584 | 0.0000 | |
| SRP064894 | TIMELESS | 8914 | RNAseq | 1.4933 | 0.0000 | |
| SRP133303 | TIMELESS | 8914 | RNAseq | 1.3497 | 0.0000 | |
| SRP159526 | TIMELESS | 8914 | RNAseq | 1.2694 | 0.0002 | |
| SRP193095 | TIMELESS | 8914 | RNAseq | 0.7626 | 0.0000 | |
| SRP219564 | TIMELESS | 8914 | RNAseq | 1.6812 | 0.0014 | |
| TCGA | TIMELESS | 8914 | RNAseq | 0.6437 | 0.0000 |
Upregulated datasets: 15; Downregulated datasets: 0.
Survival by TIMELESS expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TIMELESS:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TIMELESS | 8914 | 7 | 2 | 21 | |
| GSE20123 | TIMELESS | 8914 | 7 | 1 | 22 | |
| GSE43470 | TIMELESS | 8914 | 3 | 0 | 40 | |
| GSE46452 | TIMELESS | 8914 | 8 | 1 | 50 | |
| GSE47630 | TIMELESS | 8914 | 10 | 2 | 28 | |
| GSE54993 | TIMELESS | 8914 | 0 | 5 | 65 | |
| GSE54994 | TIMELESS | 8914 | 4 | 1 | 48 | |
| GSE60625 | TIMELESS | 8914 | 0 | 0 | 11 | |
| GSE74703 | TIMELESS | 8914 | 3 | 0 | 33 | |
| GSE74704 | TIMELESS | 8914 | 4 | 1 | 15 | |
| TCGA | TIMELESS | 8914 | 14 | 10 | 72 |
Total number of gains: 60; Total number of losses: 23; Total Number of normals: 405.
Somatic mutations of TIMELESS:
Generating mutation plots.
Highly correlated genes for TIMELESS:
Showing top 20/2059 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TIMELESS | GINS1 | 0.83952 | 12 | 0 | 11 |
| TIMELESS | MCM2 | 0.839165 | 12 | 0 | 12 |
| TIMELESS | TOP2A | 0.83782 | 13 | 0 | 13 |
| TIMELESS | BUB1 | 0.831805 | 11 | 0 | 10 |
| TIMELESS | DTL | 0.830688 | 13 | 0 | 13 |
| TIMELESS | CENPF | 0.830214 | 13 | 0 | 12 |
| TIMELESS | SPAG5 | 0.827815 | 13 | 0 | 13 |
| TIMELESS | NCAPH | 0.827438 | 9 | 0 | 9 |
| TIMELESS | CCNB2 | 0.826578 | 12 | 0 | 12 |
| TIMELESS | KNTC1 | 0.824806 | 12 | 0 | 12 |
| TIMELESS | CEP55 | 0.823374 | 12 | 0 | 12 |
| TIMELESS | CDCA2 | 0.822823 | 6 | 0 | 6 |
| TIMELESS | RAD51AP1 | 0.821067 | 13 | 0 | 13 |
| TIMELESS | NEK2 | 0.819137 | 13 | 0 | 13 |
| TIMELESS | TPX2 | 0.819026 | 13 | 0 | 13 |
| TIMELESS | UCK2 | 0.81811 | 3 | 0 | 3 |
| TIMELESS | DNMT1 | 0.817564 | 13 | 0 | 12 |
| TIMELESS | ASPM | 0.816166 | 13 | 0 | 13 |
| TIMELESS | ECT2 | 0.814533 | 12 | 0 | 12 |
| TIMELESS | UBE2C | 0.814414 | 13 | 0 | 12 |
For details and further investigation, click here
