| Full name: CDK5 regulatory subunit associated protein 3 | Alias Symbol: MST016|FLJ13660|C53|IC53|HSF-27|OK/SW-cl.114|LZAP | ||
| Type: protein-coding gene | Cytoband: 17q21.32 | ||
| Entrez ID: 80279 | HGNC ID: HGNC:18673 | Ensembl Gene: ENSG00000108465 | OMIM ID: 608202 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of CDK5RAP3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CDK5RAP3 | 80279 | 218740_s_at | 0.0183 | 0.9787 | |
| GSE20347 | CDK5RAP3 | 80279 | 218740_s_at | 0.1789 | 0.1776 | |
| GSE23400 | CDK5RAP3 | 80279 | 218740_s_at | 0.3817 | 0.0000 | |
| GSE26886 | CDK5RAP3 | 80279 | 218740_s_at | -0.6810 | 0.0015 | |
| GSE29001 | CDK5RAP3 | 80279 | 218740_s_at | 0.2060 | 0.5538 | |
| GSE38129 | CDK5RAP3 | 80279 | 218740_s_at | 0.3118 | 0.0225 | |
| GSE45670 | CDK5RAP3 | 80279 | 218740_s_at | 0.1547 | 0.4118 | |
| GSE53622 | CDK5RAP3 | 80279 | 18956 | -0.0812 | 0.2216 | |
| GSE53624 | CDK5RAP3 | 80279 | 18956 | -0.2192 | 0.0001 | |
| GSE63941 | CDK5RAP3 | 80279 | 218740_s_at | 0.9007 | 0.0190 | |
| GSE77861 | CDK5RAP3 | 80279 | 218740_s_at | 0.2872 | 0.2274 | |
| GSE97050 | CDK5RAP3 | 80279 | A_24_P292964 | -0.0780 | 0.7952 | |
| SRP007169 | CDK5RAP3 | 80279 | RNAseq | 0.3693 | 0.3632 | |
| SRP008496 | CDK5RAP3 | 80279 | RNAseq | 0.3686 | 0.1956 | |
| SRP064894 | CDK5RAP3 | 80279 | RNAseq | 0.4692 | 0.0104 | |
| SRP133303 | CDK5RAP3 | 80279 | RNAseq | -0.2116 | 0.1067 | |
| SRP159526 | CDK5RAP3 | 80279 | RNAseq | -0.0066 | 0.9850 | |
| SRP193095 | CDK5RAP3 | 80279 | RNAseq | -0.1598 | 0.0455 | |
| SRP219564 | CDK5RAP3 | 80279 | RNAseq | 0.6317 | 0.1620 | |
| TCGA | CDK5RAP3 | 80279 | RNAseq | -0.1301 | 0.0056 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by CDK5RAP3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CDK5RAP3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CDK5RAP3 | 80279 | 5 | 2 | 23 | |
| GSE20123 | CDK5RAP3 | 80279 | 5 | 2 | 23 | |
| GSE43470 | CDK5RAP3 | 80279 | 1 | 2 | 40 | |
| GSE46452 | CDK5RAP3 | 80279 | 32 | 0 | 27 | |
| GSE47630 | CDK5RAP3 | 80279 | 9 | 0 | 31 | |
| GSE54993 | CDK5RAP3 | 80279 | 2 | 4 | 64 | |
| GSE54994 | CDK5RAP3 | 80279 | 11 | 5 | 37 | |
| GSE60625 | CDK5RAP3 | 80279 | 4 | 0 | 7 | |
| GSE74703 | CDK5RAP3 | 80279 | 1 | 1 | 34 | |
| GSE74704 | CDK5RAP3 | 80279 | 4 | 1 | 15 | |
| TCGA | CDK5RAP3 | 80279 | 27 | 6 | 63 |
Total number of gains: 101; Total number of losses: 23; Total Number of normals: 364.
Somatic mutations of CDK5RAP3:
Generating mutation plots.
Highly correlated genes for CDK5RAP3:
Showing top 20/257 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CDK5RAP3 | SCML4 | 0.791229 | 3 | 0 | 3 |
| CDK5RAP3 | TBRG1 | 0.780209 | 3 | 0 | 3 |
| CDK5RAP3 | ALKBH7 | 0.752438 | 3 | 0 | 3 |
| CDK5RAP3 | PHF2 | 0.751503 | 3 | 0 | 3 |
| CDK5RAP3 | FAM120B | 0.741375 | 3 | 0 | 3 |
| CDK5RAP3 | ZRANB2 | 0.728307 | 3 | 0 | 3 |
| CDK5RAP3 | TRIM38 | 0.724695 | 3 | 0 | 3 |
| CDK5RAP3 | PIAS3 | 0.7185 | 3 | 0 | 3 |
| CDK5RAP3 | ADHFE1 | 0.713277 | 3 | 0 | 3 |
| CDK5RAP3 | IFT80 | 0.712917 | 3 | 0 | 3 |
| CDK5RAP3 | NPFF | 0.712892 | 3 | 0 | 3 |
| CDK5RAP3 | SLC35C2 | 0.711486 | 3 | 0 | 3 |
| CDK5RAP3 | MLLT6 | 0.705422 | 4 | 0 | 4 |
| CDK5RAP3 | AKAP17A | 0.702971 | 4 | 0 | 3 |
| CDK5RAP3 | RPRD2 | 0.70232 | 3 | 0 | 3 |
| CDK5RAP3 | EIF3E | 0.700847 | 3 | 0 | 3 |
| CDK5RAP3 | PARP14 | 0.698401 | 3 | 0 | 3 |
| CDK5RAP3 | NUFIP2 | 0.696897 | 3 | 0 | 3 |
| CDK5RAP3 | MDM4 | 0.691823 | 3 | 0 | 3 |
| CDK5RAP3 | ZSCAN29 | 0.69162 | 3 | 0 | 3 |
For details and further investigation, click here
