ABL1

 

Full name: ABL proto-oncogene 1, non-receptor tyrosine kinase Alias Symbol: JTK7|c-ABL|p150
Type: protein-coding gene Cytoband: 9q34.12
Entrez ID: 25 HGNC ID: HGNC:76 Ensembl Gene: ENSG00000097007 OMIM ID: 189980
Drug and gene relationship at DGIdb
Screen Evidence:
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

ABL1 involved pathways:

KEGG pathway Description View
hsa04012ErbB signaling pathway
hsa04014Ras signaling pathway
hsa04110Cell cycle
hsa04360Axon guidance
hsa04722Neurotrophin signaling pathway
hsa05200Pathways in cancer
hsa05220Chronic myeloid leukemia

 

Expression of ABL1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 ABL1 25 202123_s_at -0.1459 0.7492
GSE20347 ABL1 25 202123_s_at 0.1377 0.3249
GSE23400 ABL1 25 202123_s_at 0.1276 0.2239
GSE26886 ABL1 25 202123_s_at 0.8451 0.0001
GSE29001 ABL1 25 202123_s_at 0.3485 0.0725
GSE38129 ABL1 25 202123_s_at -0.0720 0.7452
GSE45670 ABL1 25 202123_s_at -0.5023 0.0053
GSE53622 ABL1 25 70275 -0.0764 0.3913
GSE53624 ABL1 25 70275 0.1285 0.0609
GSE63941 ABL1 25 202123_s_at -1.2977 0.0022
GSE77861 ABL1 25 202123_s_at 0.5556 0.0992
GSE97050 ABL1 25 A_23_P60180 -0.3341 0.2180
SRP007169 ABL1 25 RNAseq 1.0308 0.0030
SRP008496 ABL1 25 RNAseq 0.9834 0.0000
SRP064894 ABL1 25 RNAseq -0.2027 0.3927
SRP133303 ABL1 25 RNAseq 0.0419 0.8338
SRP159526 ABL1 25 RNAseq 0.2056 0.3495
SRP193095 ABL1 25 RNAseq 0.6534 0.0000
SRP219564 ABL1 25 RNAseq 0.0520 0.9296
TCGA ABL1 25 RNAseq -0.2503 0.0000

Upregulated datasets: 1; Downregulated datasets: 1.  

 

Survival by ABL1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of ABL1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 ABL1 25 6 9 15
GSE20123 ABL1 25 6 9 15
GSE43470 ABL1 25 5 7 31
GSE46452 ABL1 25 6 13 40
GSE47630 ABL1 25 3 16 21
GSE54993 ABL1 25 3 3 64
GSE54994 ABL1 25 12 9 32
GSE60625 ABL1 25 0 0 11
GSE74703 ABL1 25 5 5 26
GSE74704 ABL1 25 3 7 10
TCGA ABL1 25 27 26 43

Total number of gains: 76; Total number of losses: 104; Total Number of normals: 308.  

 

Somatic mutations of ABL1:

 

Generating mutation plots.

 

Highly correlated genes for ABL1:

 

Showing top 20/1267 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
ABL1MRPS60.772821303
ABL1ATP2B40.759141505
ABL1ZEB10.757957303
ABL1ZNF4610.749961303
ABL1ZNF4960.744021303
ABL1BRAT10.740391303
ABL1TNRC180.726531403
ABL1KPNA60.725031303
ABL1R3HDM20.71561303
ABL1FRY0.714587606
ABL1COMMD60.714564404
ABL1MSTO10.712249303
ABL1MGARP0.711729303
ABL1ALKBH60.710277303
ABL1STOML10.70895303
ABL1CRISPLD20.70823810010
ABL1PKIG0.7054751009
ABL1PMP220.70260712011
ABL1RAB11FIP20.701014606
ABL1TRRAP0.699806505

For details and further investigation, click here