| Full name: chloride channel CLIC like 1 | Alias Symbol: MCLC | ||
| Type: protein-coding gene | Cytoband: 1p13.3 | ||
| Entrez ID: 23155 | HGNC ID: HGNC:29675 | Ensembl Gene: ENSG00000121940 | OMIM ID: 617539 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of CLCC1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CLCC1 | 23155 | 213628_at | -0.4503 | 0.1004 | |
| GSE20347 | CLCC1 | 23155 | 213628_at | -0.6528 | 0.0000 | |
| GSE23400 | CLCC1 | 23155 | 213628_at | -0.1057 | 0.0405 | |
| GSE26886 | CLCC1 | 23155 | 213628_at | 0.5014 | 0.0545 | |
| GSE29001 | CLCC1 | 23155 | 213628_at | -0.4589 | 0.1862 | |
| GSE38129 | CLCC1 | 23155 | 213628_at | -0.6128 | 0.0000 | |
| GSE45670 | CLCC1 | 23155 | 213628_at | -0.4467 | 0.0022 | |
| GSE53622 | CLCC1 | 23155 | 82465 | 0.0406 | 0.6035 | |
| GSE53624 | CLCC1 | 23155 | 82465 | 0.1219 | 0.0338 | |
| GSE63941 | CLCC1 | 23155 | 213628_at | -1.0688 | 0.0215 | |
| GSE77861 | CLCC1 | 23155 | 213628_at | -0.3147 | 0.1756 | |
| GSE97050 | CLCC1 | 23155 | A_33_P3412149 | 0.0806 | 0.7514 | |
| SRP007169 | CLCC1 | 23155 | RNAseq | 0.4734 | 0.3606 | |
| SRP008496 | CLCC1 | 23155 | RNAseq | 0.4134 | 0.1817 | |
| SRP064894 | CLCC1 | 23155 | RNAseq | 0.1078 | 0.3921 | |
| SRP133303 | CLCC1 | 23155 | RNAseq | 0.0609 | 0.5900 | |
| SRP159526 | CLCC1 | 23155 | RNAseq | -0.0046 | 0.9831 | |
| SRP193095 | CLCC1 | 23155 | RNAseq | -0.0302 | 0.7394 | |
| SRP219564 | CLCC1 | 23155 | RNAseq | 0.1885 | 0.5904 | |
| TCGA | CLCC1 | 23155 | RNAseq | -0.2384 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by CLCC1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CLCC1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CLCC1 | 23155 | 0 | 12 | 18 | |
| GSE20123 | CLCC1 | 23155 | 0 | 11 | 19 | |
| GSE43470 | CLCC1 | 23155 | 0 | 8 | 35 | |
| GSE46452 | CLCC1 | 23155 | 2 | 1 | 56 | |
| GSE47630 | CLCC1 | 23155 | 9 | 5 | 26 | |
| GSE54993 | CLCC1 | 23155 | 0 | 1 | 69 | |
| GSE54994 | CLCC1 | 23155 | 7 | 4 | 42 | |
| GSE60625 | CLCC1 | 23155 | 0 | 0 | 11 | |
| GSE74703 | CLCC1 | 23155 | 0 | 6 | 30 | |
| GSE74704 | CLCC1 | 23155 | 0 | 7 | 13 | |
| TCGA | CLCC1 | 23155 | 8 | 26 | 62 |
Total number of gains: 26; Total number of losses: 81; Total Number of normals: 381.
Somatic mutations of CLCC1:
Generating mutation plots.
Highly correlated genes for CLCC1:
Showing top 20/546 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CLCC1 | CNTNAP3 | 0.822094 | 3 | 0 | 3 |
| CLCC1 | ZNF655 | 0.765625 | 3 | 0 | 3 |
| CLCC1 | GH2 | 0.764602 | 3 | 0 | 3 |
| CLCC1 | PHF20 | 0.752383 | 3 | 0 | 3 |
| CLCC1 | LATS2 | 0.72659 | 4 | 0 | 3 |
| CLCC1 | SYNJ1 | 0.722912 | 4 | 0 | 4 |
| CLCC1 | DCAF10 | 0.717899 | 4 | 0 | 3 |
| CLCC1 | POLR2L | 0.711126 | 3 | 0 | 3 |
| CLCC1 | BEGAIN | 0.708643 | 3 | 0 | 3 |
| CLCC1 | PTCD2 | 0.7078 | 3 | 0 | 3 |
| CLCC1 | EIF4E2 | 0.705372 | 3 | 0 | 3 |
| CLCC1 | NDUFB8 | 0.703161 | 5 | 0 | 5 |
| CLCC1 | ZNF510 | 0.698188 | 3 | 0 | 3 |
| CLCC1 | FBXO8 | 0.694207 | 3 | 0 | 3 |
| CLCC1 | SAR1A | 0.691856 | 5 | 0 | 4 |
| CLCC1 | CYYR1 | 0.690288 | 4 | 0 | 4 |
| CLCC1 | KIAA2026 | 0.69013 | 3 | 0 | 3 |
| CLCC1 | FAM219B | 0.689701 | 3 | 0 | 3 |
| CLCC1 | PRKCA | 0.688923 | 3 | 0 | 3 |
| CLCC1 | FAM107B | 0.688895 | 3 | 0 | 3 |
For details and further investigation, click here
