| Full name: mitochondrial trans-2-enoyl-CoA reductase | Alias Symbol: CGI-63|NRBF1|FASN2B|ETR1 | ||
| Type: protein-coding gene | Cytoband: 1p35.3 | ||
| Entrez ID: 51102 | HGNC ID: HGNC:19691 | Ensembl Gene: ENSG00000116353 | OMIM ID: 608205 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of MECR:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MECR | 51102 | 218664_at | 0.0973 | 0.8263 | |
| GSE20347 | MECR | 51102 | 218664_at | -0.1373 | 0.2631 | |
| GSE23400 | MECR | 51102 | 218664_at | 0.0011 | 0.9849 | |
| GSE26886 | MECR | 51102 | 218664_at | -0.1744 | 0.2303 | |
| GSE29001 | MECR | 51102 | 218664_at | -0.0857 | 0.7114 | |
| GSE38129 | MECR | 51102 | 218664_at | -0.0321 | 0.8029 | |
| GSE45670 | MECR | 51102 | 218664_at | -0.0940 | 0.4664 | |
| GSE53622 | MECR | 51102 | 33137 | 0.1032 | 0.0230 | |
| GSE53624 | MECR | 51102 | 33137 | -0.0093 | 0.8969 | |
| GSE63941 | MECR | 51102 | 218664_at | 0.7971 | 0.0095 | |
| GSE77861 | MECR | 51102 | 218664_at | -0.2553 | 0.3499 | |
| GSE97050 | MECR | 51102 | A_23_P114808 | -0.0266 | 0.9035 | |
| SRP007169 | MECR | 51102 | RNAseq | -0.1677 | 0.7401 | |
| SRP008496 | MECR | 51102 | RNAseq | -0.4047 | 0.2265 | |
| SRP064894 | MECR | 51102 | RNAseq | 0.5159 | 0.0297 | |
| SRP133303 | MECR | 51102 | RNAseq | 0.0481 | 0.7091 | |
| SRP159526 | MECR | 51102 | RNAseq | 0.0447 | 0.8791 | |
| SRP193095 | MECR | 51102 | RNAseq | -0.0255 | 0.7869 | |
| SRP219564 | MECR | 51102 | RNAseq | -0.0903 | 0.7962 | |
| TCGA | MECR | 51102 | RNAseq | -0.0339 | 0.5825 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by MECR expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MECR:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MECR | 51102 | 0 | 6 | 24 | |
| GSE20123 | MECR | 51102 | 0 | 5 | 25 | |
| GSE43470 | MECR | 51102 | 3 | 6 | 34 | |
| GSE46452 | MECR | 51102 | 5 | 1 | 53 | |
| GSE47630 | MECR | 51102 | 8 | 3 | 29 | |
| GSE54993 | MECR | 51102 | 2 | 1 | 67 | |
| GSE54994 | MECR | 51102 | 10 | 4 | 39 | |
| GSE60625 | MECR | 51102 | 0 | 0 | 11 | |
| GSE74703 | MECR | 51102 | 2 | 4 | 30 | |
| GSE74704 | MECR | 51102 | 0 | 0 | 20 | |
| TCGA | MECR | 51102 | 11 | 21 | 64 |
Total number of gains: 41; Total number of losses: 51; Total Number of normals: 396.
Somatic mutations of MECR:
Generating mutation plots.
Highly correlated genes for MECR:
Showing top 20/99 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MECR | ACTR3B | 0.768348 | 3 | 0 | 3 |
| MECR | HINFP | 0.742947 | 3 | 0 | 3 |
| MECR | RAB11FIP4 | 0.734004 | 3 | 0 | 3 |
| MECR | BCL2L12 | 0.725434 | 3 | 0 | 3 |
| MECR | NUP62CL | 0.722384 | 3 | 0 | 3 |
| MECR | KLHL14 | 0.718945 | 3 | 0 | 3 |
| MECR | SNORA71A | 0.718741 | 3 | 0 | 3 |
| MECR | CDC42 | 0.711515 | 3 | 0 | 3 |
| MECR | ZNF157 | 0.704198 | 3 | 0 | 3 |
| MECR | CAPN10 | 0.699448 | 3 | 0 | 3 |
| MECR | PGLYRP1 | 0.698769 | 3 | 0 | 3 |
| MECR | KRT36 | 0.697747 | 3 | 0 | 3 |
| MECR | GPR17 | 0.688092 | 4 | 0 | 4 |
| MECR | PIP5KL1 | 0.680101 | 3 | 0 | 3 |
| MECR | TRIM17 | 0.676436 | 3 | 0 | 3 |
| MECR | OR10W1 | 0.674314 | 3 | 0 | 3 |
| MECR | SF3A3 | 0.673139 | 3 | 0 | 3 |
| MECR | SCRN2 | 0.672281 | 3 | 0 | 3 |
| MECR | NKX2-8 | 0.668527 | 4 | 0 | 3 |
| MECR | KIAA1671 | 0.668108 | 3 | 0 | 3 |
For details and further investigation, click here
