Full name: cell division cycle 42	Alias Symbol: G25K|CDC42Hs
Type: protein-coding gene	Cytoband: 1p36.12
Entrez ID: 998	HGNC ID: HGNC:1736	Ensembl Gene: ENSG00000070831	OMIM ID: 116952
Drug and gene relationship at DGIdb
Screen Evidence: Knocking out of this gene by CRIPR/Cas9 screen found 272/325 cell lines had fitness change in Project Score. Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

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CDC42 involved pathways:

KEGG pathway	Description	View
hsa04010	MAPK signaling pathway	View
hsa04014	Ras signaling pathway	View
hsa04015	Rap1 signaling pathway	View
hsa04062	Chemokine signaling pathway	View
hsa04360	Axon guidance	View
hsa04370	VEGF signaling pathway	View
hsa04510	Focal adhesion	View
hsa04520	Adherens junction	View
hsa04530	Tight junction	View
hsa04660	T cell receptor signaling pathway	View
hsa04666	Fc gamma R-mediated phagocytosis	View
hsa04670	Leukocyte transendothelial migration	View
hsa04722	Neurotrophin signaling pathway	View
hsa04810	Regulation of actin cytoskeleton	View
hsa04912	GnRH signaling pathway	View
hsa04932	Non-alcoholic fatty liver disease (NAFLD)	View
hsa04933	AGE-RAGE signaling pathway in diabetic complications	View
hsa05100	Bacterial invasion of epithelial cells	View
hsa05131	Shigellosis	View
hsa05132	Salmonella infection	View
hsa05200	Pathways in cancer	View
hsa05205	Proteoglycans in cancer	View
hsa05211	Renal cell carcinoma	View
hsa05212	Pancreatic cancer	View

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Expression of CDC42:

 

Dataset	Gene	EntrezID	Probe	Log2FC	Adj.pValue	Expression
GSE17351	CDC42	998	226400_at	-0.0784	0.8743	Show
GSE20347	CDC42	998	208727_s_at	-0.7861	0.0922	Show
GSE23400	CDC42	998	208727_s_at	-0.2523	0.0536	Show
GSE26886	CDC42	998	226400_at	0.2130	0.5414	Show
GSE29001	CDC42	998	208727_s_at	-0.5748	0.0477	Show
GSE38129	CDC42	998	208727_s_at	-0.2436	0.5511	Show
GSE45670	CDC42	998	208727_s_at	-0.1588	0.5985	Show
GSE53622	CDC42	998	34078	-0.1650	0.0019	Show
GSE53624	CDC42	998	34078	-0.2124	0.0000	Show
GSE63941	CDC42	998	226400_at	2.5221	0.0000	Show
GSE77861	CDC42	998	226400_at	-0.4089	0.2895	Show
GSE97050	CDC42	998	A_33_P3257150	0.1275	0.5515	Show
SRP007169	CDC42	998	RNAseq	-0.5849	0.1900	Show
SRP008496	CDC42	998	RNAseq	-0.5718	0.0697	Show
SRP064894	CDC42	998	RNAseq	-0.5373	0.0032	Show
SRP133303	CDC42	998	RNAseq	-0.0087	0.9561	Show
SRP159526	CDC42	998	RNAseq	-0.5044	0.1215	Show
SRP193095	CDC42	998	RNAseq	-0.5867	0.0000	Show
SRP219564	CDC42	998	RNAseq	-0.7576	0.0740	Show
TCGA	CDC42	998	RNAseq	0.0188	0.6476	Show

Upregulated datasets: 1; Downregulated datasets: 0.  Download Data

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Survival by CDC42 expression:

 

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Copy number change of CDC42:

 

Dataset	Gene	EntrezID	Gain	Loss	Normal	Detail
GSE15526	CDC42	998	0	5	25	Show
GSE20123	CDC42	998	0	4	26	Show
GSE43470	CDC42	998	2	6	35	Show
GSE46452	CDC42	998	5	1	53	Show
GSE47630	CDC42	998	8	3	29	Show
GSE54993	CDC42	998	2	1	67	Show
GSE54994	CDC42	998	11	4	38	Show
GSE60625	CDC42	998	0	0	11	Show
GSE74703	CDC42	998	1	4	31	Show
GSE74704	CDC42	998	0	0	20	Show
TCGA	CDC42	998	9	23	64	Show

Total number of gains: 38; Total number of losses: 51; Total Number of normals: 399.  Download Data

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Somatic mutations of CDC42:

 

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Highly correlated genes for CDC42:

 

Showing top 20/46 corelated genes with mean PCC>0.5.

Gene1	Gene2	Mean PCC	Num. Datasets	Num. PCC<0	Num. PCC>0.5
CDC42	MECR	0.711515	3	0	3
CDC42	SNORA71A	0.681485	3	0	3
CDC42	PARS2	0.637837	3	0	3
CDC42	PTBP3	0.611819	5	0	4
CDC42	CDK16	0.607396	4	0	4
CDC42	RPL6	0.600481	5	0	3
CDC42	ADK	0.592705	6	0	4
CDC42	ESRP1	0.584153	4	0	3
CDC42	C1orf74	0.579208	3	0	3
CDC42	YIPF1	0.578708	6	0	4
CDC42	ADIRF	0.57595	4	0	3
CDC42	RIPK4	0.570497	5	0	3
CDC42	MAL2	0.564569	4	0	3
CDC42	FBXO34	0.561684	8	0	5
CDC42	FGFBP1	0.559829	5	0	3
CDC42	DKK4	0.559203	3	0	3
CDC42	LRRC1	0.55644	5	0	3
CDC42	SMUG1	0.55264	5	0	3
CDC42	IL17RE	0.552027	4	0	3
CDC42	EBP	0.548343	7	0	4

For details and further investigation, click here