| Full name: isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 15q25.1 | ||
| Entrez ID: 3419 | HGNC ID: HGNC:5384 | Ensembl Gene: ENSG00000166411 | OMIM ID: 601149 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of IDH3A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | IDH3A | 3419 | 202069_s_at | -0.0326 | 0.9798 | |
| GSE20347 | IDH3A | 3419 | 202069_s_at | 0.3755 | 0.1870 | |
| GSE23400 | IDH3A | 3419 | 202069_s_at | 0.2702 | 0.0062 | |
| GSE26886 | IDH3A | 3419 | 202069_s_at | -0.5058 | 0.1046 | |
| GSE29001 | IDH3A | 3419 | 202069_s_at | 0.4176 | 0.2986 | |
| GSE38129 | IDH3A | 3419 | 202069_s_at | 0.5301 | 0.0145 | |
| GSE45670 | IDH3A | 3419 | 202069_s_at | 0.8206 | 0.0004 | |
| GSE63941 | IDH3A | 3419 | 202069_s_at | 0.8948 | 0.0462 | |
| GSE77861 | IDH3A | 3419 | 202069_s_at | 0.5615 | 0.2037 | |
| GSE97050 | IDH3A | 3419 | A_23_P140668 | -0.0962 | 0.7032 | |
| SRP007169 | IDH3A | 3419 | RNAseq | -0.4684 | 0.3628 | |
| SRP008496 | IDH3A | 3419 | RNAseq | -0.4745 | 0.1679 | |
| SRP064894 | IDH3A | 3419 | RNAseq | -0.2456 | 0.0786 | |
| SRP133303 | IDH3A | 3419 | RNAseq | 0.4490 | 0.0791 | |
| SRP159526 | IDH3A | 3419 | RNAseq | 0.2379 | 0.5770 | |
| SRP193095 | IDH3A | 3419 | RNAseq | 0.0563 | 0.7344 | |
| SRP219564 | IDH3A | 3419 | RNAseq | -0.5591 | 0.1023 | |
| TCGA | IDH3A | 3419 | RNAseq | 0.0414 | 0.4202 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by IDH3A expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of IDH3A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | IDH3A | 3419 | 7 | 1 | 22 | |
| GSE20123 | IDH3A | 3419 | 7 | 1 | 22 | |
| GSE43470 | IDH3A | 3419 | 4 | 5 | 34 | |
| GSE46452 | IDH3A | 3419 | 3 | 7 | 49 | |
| GSE47630 | IDH3A | 3419 | 8 | 10 | 22 | |
| GSE54993 | IDH3A | 3419 | 5 | 6 | 59 | |
| GSE54994 | IDH3A | 3419 | 5 | 6 | 42 | |
| GSE60625 | IDH3A | 3419 | 4 | 0 | 7 | |
| GSE74703 | IDH3A | 3419 | 4 | 3 | 29 | |
| GSE74704 | IDH3A | 3419 | 3 | 1 | 16 | |
| TCGA | IDH3A | 3419 | 14 | 15 | 67 |
Total number of gains: 64; Total number of losses: 55; Total Number of normals: 369.
Somatic mutations of IDH3A:
Generating mutation plots.
Highly correlated genes for IDH3A:
Showing top 20/422 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| IDH3A | UBR1 | 0.796914 | 3 | 0 | 3 |
| IDH3A | ZC3H12C | 0.779911 | 3 | 0 | 3 |
| IDH3A | SPRR4 | 0.775954 | 3 | 0 | 3 |
| IDH3A | ZNF343 | 0.771817 | 3 | 0 | 3 |
| IDH3A | NUS1 | 0.760927 | 3 | 0 | 3 |
| IDH3A | TAS2R19 | 0.747796 | 3 | 0 | 3 |
| IDH3A | CLP1 | 0.734561 | 4 | 0 | 4 |
| IDH3A | FEM1B | 0.721463 | 3 | 0 | 3 |
| IDH3A | IREB2 | 0.717786 | 3 | 0 | 3 |
| IDH3A | ERCC8 | 0.710169 | 3 | 0 | 3 |
| IDH3A | BOLA3 | 0.708048 | 3 | 0 | 3 |
| IDH3A | C16orf72 | 0.704608 | 3 | 0 | 3 |
| IDH3A | PLEKHA8 | 0.702898 | 3 | 0 | 3 |
| IDH3A | SDHAF2 | 0.701527 | 3 | 0 | 3 |
| IDH3A | VPS29 | 0.70062 | 3 | 0 | 3 |
| IDH3A | MRPL47 | 0.694183 | 4 | 0 | 4 |
| IDH3A | DDX1 | 0.693952 | 4 | 0 | 3 |
| IDH3A | FAM98B | 0.690816 | 3 | 0 | 3 |
| IDH3A | IL6R | 0.689067 | 3 | 0 | 3 |
| IDH3A | SLC44A1 | 0.682469 | 4 | 0 | 3 |
For details and further investigation, click here
