| Full name: ADAM metallopeptidase with thrombospondin type 1 motif 18 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 16q23.1 | ||
| Entrez ID: 170692 | HGNC ID: HGNC:17110 | Ensembl Gene: ENSG00000140873 | OMIM ID: 607512 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of ADAMTS18:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ADAMTS18 | 170692 | 1553234_at | -0.0302 | 0.9409 | |
| GSE26886 | ADAMTS18 | 170692 | 1553234_at | 0.0691 | 0.6227 | |
| GSE45670 | ADAMTS18 | 170692 | 1553234_at | 0.3547 | 0.0008 | |
| GSE53622 | ADAMTS18 | 170692 | 597 | 0.8670 | 0.0258 | |
| GSE53624 | ADAMTS18 | 170692 | 597 | 1.1487 | 0.0000 | |
| GSE63941 | ADAMTS18 | 170692 | 1553234_at | -0.1081 | 0.5189 | |
| GSE77861 | ADAMTS18 | 170692 | 1553234_at | -0.0635 | 0.6996 | |
| GSE97050 | ADAMTS18 | 170692 | A_32_P34844 | 0.1242 | 0.7105 | |
| SRP133303 | ADAMTS18 | 170692 | RNAseq | 1.0264 | 0.0068 | |
| TCGA | ADAMTS18 | 170692 | RNAseq | 1.9644 | 0.0024 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by ADAMTS18 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ADAMTS18:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ADAMTS18 | 170692 | 3 | 2 | 25 | |
| GSE20123 | ADAMTS18 | 170692 | 3 | 2 | 25 | |
| GSE43470 | ADAMTS18 | 170692 | 2 | 8 | 33 | |
| GSE46452 | ADAMTS18 | 170692 | 37 | 2 | 20 | |
| GSE47630 | ADAMTS18 | 170692 | 11 | 8 | 21 | |
| GSE54993 | ADAMTS18 | 170692 | 2 | 4 | 64 | |
| GSE54994 | ADAMTS18 | 170692 | 7 | 12 | 34 | |
| GSE60625 | ADAMTS18 | 170692 | 4 | 0 | 7 | |
| GSE74703 | ADAMTS18 | 170692 | 2 | 6 | 28 | |
| GSE74704 | ADAMTS18 | 170692 | 2 | 1 | 17 | |
| TCGA | ADAMTS18 | 170692 | 25 | 14 | 57 |
Total number of gains: 98; Total number of losses: 59; Total Number of normals: 331.
Somatic mutations of ADAMTS18:
Generating mutation plots.
Highly correlated genes for ADAMTS18:
Showing top 20/52 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ADAMTS18 | CCNH | 0.728685 | 3 | 0 | 3 |
| ADAMTS18 | ANPEP | 0.708697 | 3 | 0 | 3 |
| ADAMTS18 | GUCA2B | 0.705274 | 3 | 0 | 3 |
| ADAMTS18 | EIF3I | 0.696899 | 3 | 0 | 3 |
| ADAMTS18 | CYSLTR2 | 0.686839 | 3 | 0 | 3 |
| ADAMTS18 | ZNF460 | 0.685961 | 3 | 0 | 3 |
| ADAMTS18 | NLRP3 | 0.685355 | 3 | 0 | 3 |
| ADAMTS18 | FAM222A-AS1 | 0.685326 | 3 | 0 | 3 |
| ADAMTS18 | WDR4 | 0.685273 | 3 | 0 | 3 |
| ADAMTS18 | CALY | 0.676784 | 3 | 0 | 3 |
| ADAMTS18 | GRAPL | 0.664565 | 3 | 0 | 3 |
| ADAMTS18 | SRA1 | 0.648296 | 3 | 0 | 3 |
| ADAMTS18 | MEF2A | 0.645303 | 3 | 0 | 3 |
| ADAMTS18 | PLEKHG2 | 0.644423 | 4 | 0 | 3 |
| ADAMTS18 | KCNN1 | 0.638423 | 3 | 0 | 3 |
| ADAMTS18 | SIGLEC6 | 0.633794 | 4 | 0 | 3 |
| ADAMTS18 | WDR93 | 0.62883 | 3 | 0 | 3 |
| ADAMTS18 | OR8G1 | 0.626932 | 3 | 0 | 3 |
| ADAMTS18 | ATP1A4 | 0.623389 | 3 | 0 | 3 |
| ADAMTS18 | PSMA2 | 0.622226 | 3 | 0 | 3 |
For details and further investigation, click here
