| Full name: cyclin dependent kinase 10 | Alias Symbol: PISSLRE | ||
| Type: protein-coding gene | Cytoband: 16q24.3 | ||
| Entrez ID: 8558 | HGNC ID: HGNC:1770 | Ensembl Gene: ENSG00000185324 | OMIM ID: 603464 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of CDK10:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CDK10 | 8558 | 210622_x_at | 0.2985 | 0.4280 | |
| GSE20347 | CDK10 | 8558 | 203469_s_at | 0.1069 | 0.2697 | |
| GSE23400 | CDK10 | 8558 | 203469_s_at | 0.1946 | 0.0003 | |
| GSE26886 | CDK10 | 8558 | 203468_at | 0.2665 | 0.2460 | |
| GSE29001 | CDK10 | 8558 | 203469_s_at | 0.1236 | 0.4966 | |
| GSE38129 | CDK10 | 8558 | 203469_s_at | 0.2288 | 0.0278 | |
| GSE45670 | CDK10 | 8558 | 203468_at | 0.4367 | 0.0012 | |
| GSE53622 | CDK10 | 8558 | 9923 | -0.1021 | 0.1405 | |
| GSE53624 | CDK10 | 8558 | 52028 | 0.1808 | 0.0309 | |
| GSE63941 | CDK10 | 8558 | 203469_s_at | -0.0768 | 0.8261 | |
| GSE77861 | CDK10 | 8558 | 203469_s_at | 0.0996 | 0.5463 | |
| GSE97050 | CDK10 | 8558 | A_24_P65199 | -0.1148 | 0.7831 | |
| SRP007169 | CDK10 | 8558 | RNAseq | -0.1969 | 0.6554 | |
| SRP008496 | CDK10 | 8558 | RNAseq | -0.3230 | 0.2756 | |
| SRP064894 | CDK10 | 8558 | RNAseq | 0.6658 | 0.0058 | |
| SRP133303 | CDK10 | 8558 | RNAseq | 0.4870 | 0.0509 | |
| SRP159526 | CDK10 | 8558 | RNAseq | 0.1268 | 0.6299 | |
| SRP193095 | CDK10 | 8558 | RNAseq | 0.2449 | 0.0531 | |
| SRP219564 | CDK10 | 8558 | RNAseq | 0.0672 | 0.8383 | |
| TCGA | CDK10 | 8558 | RNAseq | -0.0400 | 0.4581 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by CDK10 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CDK10:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CDK10 | 8558 | 4 | 3 | 23 | |
| GSE20123 | CDK10 | 8558 | 4 | 3 | 23 | |
| GSE43470 | CDK10 | 8558 | 1 | 13 | 29 | |
| GSE46452 | CDK10 | 8558 | 38 | 1 | 20 | |
| GSE47630 | CDK10 | 8558 | 11 | 9 | 20 | |
| GSE54993 | CDK10 | 8558 | 3 | 4 | 63 | |
| GSE54994 | CDK10 | 8558 | 9 | 11 | 33 | |
| GSE60625 | CDK10 | 8558 | 4 | 0 | 7 | |
| GSE74703 | CDK10 | 8558 | 1 | 9 | 26 | |
| GSE74704 | CDK10 | 8558 | 3 | 1 | 16 | |
| TCGA | CDK10 | 8558 | 26 | 15 | 55 |
Total number of gains: 104; Total number of losses: 69; Total Number of normals: 315.
Somatic mutations of CDK10:
Generating mutation plots.
Highly correlated genes for CDK10:
Showing top 20/392 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CDK10 | MED23 | 0.780296 | 3 | 0 | 3 |
| CDK10 | PPP5C | 0.740319 | 4 | 0 | 4 |
| CDK10 | DDX59 | 0.731511 | 3 | 0 | 3 |
| CDK10 | MLLT6 | 0.727849 | 4 | 0 | 4 |
| CDK10 | VCP | 0.725691 | 3 | 0 | 3 |
| CDK10 | ZNF740 | 0.720873 | 3 | 0 | 3 |
| CDK10 | SPG7 | 0.719117 | 4 | 0 | 3 |
| CDK10 | PREX1 | 0.71393 | 3 | 0 | 3 |
| CDK10 | ZNF594 | 0.70916 | 3 | 0 | 3 |
| CDK10 | MZT2B | 0.708422 | 5 | 0 | 5 |
| CDK10 | RICTOR | 0.69345 | 3 | 0 | 3 |
| CDK10 | SLC25A29 | 0.687245 | 3 | 0 | 3 |
| CDK10 | C9orf64 | 0.686406 | 4 | 0 | 3 |
| CDK10 | AAAS | 0.683641 | 3 | 0 | 3 |
| CDK10 | ARHGEF7 | 0.679724 | 3 | 0 | 3 |
| CDK10 | FAM53B | 0.67961 | 4 | 0 | 4 |
| CDK10 | ELOF1 | 0.678818 | 3 | 0 | 3 |
| CDK10 | NEIL2 | 0.676269 | 3 | 0 | 3 |
| CDK10 | PIF1 | 0.674553 | 4 | 0 | 4 |
| CDK10 | DLG5 | 0.674145 | 3 | 0 | 3 |
For details and further investigation, click here
