| Full name: matrix metallopeptidase 15 | Alias Symbol: MT2-MMP|MTMMP2|SMCP-2 | ||
| Type: protein-coding gene | Cytoband: 16q21 | ||
| Entrez ID: 4324 | HGNC ID: HGNC:7161 | Ensembl Gene: ENSG00000102996 | OMIM ID: 602261 |
| Drug and gene relationship at DGIdb | |||
Expression of MMP15:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MMP15 | 4324 | 203365_s_at | 0.9217 | 0.0336 | |
| GSE20347 | MMP15 | 4324 | 203365_s_at | 0.5054 | 0.0047 | |
| GSE23400 | MMP15 | 4324 | 203365_s_at | 0.1258 | 0.0096 | |
| GSE26886 | MMP15 | 4324 | 203365_s_at | 0.7884 | 0.0002 | |
| GSE29001 | MMP15 | 4324 | 203365_s_at | 0.2206 | 0.3284 | |
| GSE38129 | MMP15 | 4324 | 203365_s_at | 0.4095 | 0.0095 | |
| GSE45670 | MMP15 | 4324 | 203365_s_at | 0.3598 | 0.0014 | |
| GSE53622 | MMP15 | 4324 | 30256 | 0.1299 | 0.1836 | |
| GSE53624 | MMP15 | 4324 | 30256 | 0.3399 | 0.0000 | |
| GSE63941 | MMP15 | 4324 | 203365_s_at | 0.2959 | 0.5483 | |
| GSE77861 | MMP15 | 4324 | 203365_s_at | 0.1027 | 0.4899 | |
| GSE97050 | MMP15 | 4324 | A_24_P116535 | -0.2023 | 0.3924 | |
| SRP007169 | MMP15 | 4324 | RNAseq | 2.3766 | 0.0022 | |
| SRP008496 | MMP15 | 4324 | RNAseq | 2.5025 | 0.0000 | |
| SRP064894 | MMP15 | 4324 | RNAseq | 1.1171 | 0.0001 | |
| SRP133303 | MMP15 | 4324 | RNAseq | 0.5759 | 0.0386 | |
| SRP159526 | MMP15 | 4324 | RNAseq | 0.7893 | 0.0123 | |
| SRP193095 | MMP15 | 4324 | RNAseq | -0.1593 | 0.6945 | |
| SRP219564 | MMP15 | 4324 | RNAseq | 0.5226 | 0.4047 | |
| TCGA | MMP15 | 4324 | RNAseq | -0.4393 | 0.0000 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by MMP15 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MMP15:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MMP15 | 4324 | 6 | 0 | 24 | |
| GSE20123 | MMP15 | 4324 | 6 | 1 | 23 | |
| GSE43470 | MMP15 | 4324 | 2 | 7 | 34 | |
| GSE46452 | MMP15 | 4324 | 38 | 1 | 20 | |
| GSE47630 | MMP15 | 4324 | 10 | 8 | 22 | |
| GSE54993 | MMP15 | 4324 | 2 | 4 | 64 | |
| GSE54994 | MMP15 | 4324 | 6 | 10 | 37 | |
| GSE60625 | MMP15 | 4324 | 4 | 0 | 7 | |
| GSE74703 | MMP15 | 4324 | 2 | 5 | 29 | |
| GSE74704 | MMP15 | 4324 | 5 | 0 | 15 | |
| TCGA | MMP15 | 4324 | 26 | 11 | 59 |
Total number of gains: 107; Total number of losses: 47; Total Number of normals: 334.
Somatic mutations of MMP15:
Generating mutation plots.
Highly correlated genes for MMP15:
Showing top 20/998 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MMP15 | RTTN | 0.815054 | 3 | 0 | 3 |
| MMP15 | METTL23 | 0.807341 | 3 | 0 | 3 |
| MMP15 | SMNDC1 | 0.797882 | 3 | 0 | 3 |
| MMP15 | RPL26L1 | 0.790962 | 3 | 0 | 3 |
| MMP15 | CTU2 | 0.78336 | 3 | 0 | 3 |
| MMP15 | EIF3G | 0.774571 | 3 | 0 | 3 |
| MMP15 | STAT6 | 0.770318 | 3 | 0 | 3 |
| MMP15 | SNAPC2 | 0.769177 | 4 | 0 | 4 |
| MMP15 | SASS6 | 0.76108 | 4 | 0 | 3 |
| MMP15 | IFI27L2 | 0.755426 | 3 | 0 | 3 |
| MMP15 | SLC25A29 | 0.753938 | 3 | 0 | 3 |
| MMP15 | FARS2 | 0.753152 | 4 | 0 | 4 |
| MMP15 | GCSH | 0.752349 | 3 | 0 | 3 |
| MMP15 | NEDD1 | 0.752168 | 3 | 0 | 3 |
| MMP15 | ADO | 0.750396 | 3 | 0 | 3 |
| MMP15 | ANKRD54 | 0.748641 | 3 | 0 | 3 |
| MMP15 | SORBS3 | 0.744595 | 3 | 0 | 3 |
| MMP15 | ACY1 | 0.743939 | 3 | 0 | 3 |
| MMP15 | MCMBP | 0.743749 | 3 | 0 | 3 |
| MMP15 | ARHGEF11 | 0.743199 | 3 | 0 | 3 |
For details and further investigation, click here
