| Full name: phospholipase A2 group IIA | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 1p36.13 | ||
| Entrez ID: 5320 | HGNC ID: HGNC:9031 | Ensembl Gene: ENSG00000188257 | OMIM ID: 172411 |
| Drug and gene relationship at DGIdb | |||
PLA2G2A involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04014 | Ras signaling pathway | |
| hsa04270 | Vascular smooth muscle contraction |
Expression of PLA2G2A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PLA2G2A | 5320 | 203649_s_at | -2.7241 | 0.1717 | |
| GSE20347 | PLA2G2A | 5320 | 203649_s_at | -0.5080 | 0.0165 | |
| GSE23400 | PLA2G2A | 5320 | 203649_s_at | -0.3904 | 0.1502 | |
| GSE26886 | PLA2G2A | 5320 | 203649_s_at | -0.4126 | 0.0608 | |
| GSE29001 | PLA2G2A | 5320 | 203649_s_at | -0.0711 | 0.7465 | |
| GSE38129 | PLA2G2A | 5320 | 203649_s_at | -0.8845 | 0.0421 | |
| GSE45670 | PLA2G2A | 5320 | 203649_s_at | -0.9572 | 0.0000 | |
| GSE53622 | PLA2G2A | 5320 | 59506 | -4.0845 | 0.0000 | |
| GSE53624 | PLA2G2A | 5320 | 59506 | -3.6346 | 0.0000 | |
| GSE63941 | PLA2G2A | 5320 | 203649_s_at | 0.0963 | 0.5679 | |
| GSE77861 | PLA2G2A | 5320 | 203649_s_at | -1.4054 | 0.0174 | |
| GSE97050 | PLA2G2A | 5320 | A_23_P321949 | 1.0580 | 0.3442 | |
| SRP064894 | PLA2G2A | 5320 | RNAseq | -0.3279 | 0.6448 | |
| SRP133303 | PLA2G2A | 5320 | RNAseq | -3.0932 | 0.0002 | |
| SRP219564 | PLA2G2A | 5320 | RNAseq | 3.0741 | 0.0564 | |
| TCGA | PLA2G2A | 5320 | RNAseq | -1.2516 | 0.0207 |
Upregulated datasets: 0; Downregulated datasets: 5.
Survival by PLA2G2A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PLA2G2A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PLA2G2A | 5320 | 0 | 5 | 25 | |
| GSE20123 | PLA2G2A | 5320 | 0 | 4 | 26 | |
| GSE43470 | PLA2G2A | 5320 | 0 | 8 | 35 | |
| GSE46452 | PLA2G2A | 5320 | 5 | 1 | 53 | |
| GSE47630 | PLA2G2A | 5320 | 8 | 3 | 29 | |
| GSE54993 | PLA2G2A | 5320 | 3 | 1 | 66 | |
| GSE54994 | PLA2G2A | 5320 | 11 | 4 | 38 | |
| GSE60625 | PLA2G2A | 5320 | 0 | 0 | 11 | |
| GSE74703 | PLA2G2A | 5320 | 0 | 5 | 31 | |
| GSE74704 | PLA2G2A | 5320 | 0 | 0 | 20 | |
| TCGA | PLA2G2A | 5320 | 10 | 22 | 64 |
Total number of gains: 37; Total number of losses: 53; Total Number of normals: 398.
Somatic mutations of PLA2G2A:
Generating mutation plots.
Highly correlated genes for PLA2G2A:
Showing top 20/1011 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PLA2G2A | MYCN | 0.773278 | 3 | 0 | 3 |
| PLA2G2A | PI16 | 0.743115 | 4 | 0 | 4 |
| PLA2G2A | ARSE | 0.732931 | 3 | 0 | 3 |
| PLA2G2A | SLITRK4 | 0.721501 | 3 | 0 | 3 |
| PLA2G2A | SH3BGRL2 | 0.721021 | 5 | 0 | 5 |
| PLA2G2A | IGF1 | 0.719003 | 9 | 0 | 8 |
| PLA2G2A | C9orf16 | 0.712449 | 3 | 0 | 3 |
| PLA2G2A | FAM219B | 0.708623 | 3 | 0 | 3 |
| PLA2G2A | CYSLTR2 | 0.70728 | 4 | 0 | 3 |
| PLA2G2A | SHB | 0.702163 | 3 | 0 | 3 |
| PLA2G2A | SLC7A3 | 0.691303 | 3 | 0 | 3 |
| PLA2G2A | MAMDC2 | 0.686936 | 4 | 0 | 4 |
| PLA2G2A | MAP1A | 0.684742 | 4 | 0 | 4 |
| PLA2G2A | CLEC3B | 0.684519 | 3 | 0 | 3 |
| PLA2G2A | MAP4 | 0.683834 | 3 | 0 | 3 |
| PLA2G2A | NFIA | 0.683454 | 5 | 0 | 5 |
| PLA2G2A | MGAT3 | 0.681246 | 3 | 0 | 3 |
| PLA2G2A | KCNK17 | 0.678961 | 4 | 0 | 3 |
| PLA2G2A | ZNF625 | 0.678306 | 3 | 0 | 3 |
| PLA2G2A | ZNF436 | 0.678297 | 3 | 0 | 3 |
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