| Full name: programmed cell death 6 | Alias Symbol: ALG-2|PEF1B | ||
| Type: protein-coding gene | Cytoband: 5p15.33 | ||
| Entrez ID: 10016 | HGNC ID: HGNC:8765 | Ensembl Gene: ENSG00000249915 | OMIM ID: 601057 |
| Drug and gene relationship at DGIdb | |||
Expression of PDCD6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PDCD6 | 10016 | 203415_at | 0.2781 | 0.4424 | |
| GSE20347 | PDCD6 | 10016 | 203415_at | -0.2346 | 0.1679 | |
| GSE23400 | PDCD6 | 10016 | 203415_at | -0.2729 | 0.0052 | |
| GSE26886 | PDCD6 | 10016 | 203415_at | -0.0285 | 0.9233 | |
| GSE29001 | PDCD6 | 10016 | 222380_s_at | 0.3116 | 0.4712 | |
| GSE38129 | PDCD6 | 10016 | 203415_at | 0.0779 | 0.6874 | |
| GSE45670 | PDCD6 | 10016 | 203415_at | -0.2694 | 0.0725 | |
| GSE53622 | PDCD6 | 10016 | 120871 | -0.3513 | 0.0001 | |
| GSE53624 | PDCD6 | 10016 | 120871 | -0.4859 | 0.0000 | |
| GSE63941 | PDCD6 | 10016 | 203415_at | 0.4040 | 0.3525 | |
| GSE77861 | PDCD6 | 10016 | 203415_at | 0.1543 | 0.6478 | |
| GSE97050 | PDCD6 | 10016 | A_23_P218997 | 0.0715 | 0.8802 | |
| SRP007169 | PDCD6 | 10016 | RNAseq | -1.8148 | 0.0000 | |
| SRP008496 | PDCD6 | 10016 | RNAseq | -1.6655 | 0.0000 | |
| SRP064894 | PDCD6 | 10016 | RNAseq | -0.8939 | 0.0000 | |
| SRP133303 | PDCD6 | 10016 | RNAseq | -0.2245 | 0.1547 | |
| SRP159526 | PDCD6 | 10016 | RNAseq | -0.2618 | 0.2864 | |
| SRP193095 | PDCD6 | 10016 | RNAseq | -0.6653 | 0.0000 | |
| SRP219564 | PDCD6 | 10016 | RNAseq | -0.2401 | 0.6487 | |
| TCGA | PDCD6 | 10016 | RNAseq | 0.2010 | 0.0016 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by PDCD6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PDCD6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PDCD6 | 10016 | 13 | 1 | 16 | |
| GSE20123 | PDCD6 | 10016 | 13 | 1 | 16 | |
| GSE43470 | PDCD6 | 10016 | 16 | 0 | 27 | |
| GSE46452 | PDCD6 | 10016 | 6 | 22 | 31 | |
| GSE47630 | PDCD6 | 10016 | 11 | 9 | 20 | |
| GSE54993 | PDCD6 | 10016 | 5 | 6 | 59 | |
| GSE54994 | PDCD6 | 10016 | 29 | 1 | 23 | |
| GSE60625 | PDCD6 | 10016 | 0 | 0 | 11 | |
| GSE74703 | PDCD6 | 10016 | 13 | 0 | 23 | |
| GSE74704 | PDCD6 | 10016 | 11 | 0 | 9 | |
| TCGA | PDCD6 | 10016 | 60 | 4 | 32 |
Total number of gains: 177; Total number of losses: 44; Total Number of normals: 267.
Somatic mutations of PDCD6:
Generating mutation plots.
Highly correlated genes for PDCD6:
Showing top 20/272 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PDCD6 | TET2 | 0.772312 | 3 | 0 | 3 |
| PDCD6 | LPCAT3 | 0.769418 | 3 | 0 | 3 |
| PDCD6 | SLC22A23 | 0.769269 | 3 | 0 | 3 |
| PDCD6 | MRPL3 | 0.759659 | 3 | 0 | 3 |
| PDCD6 | STX6 | 0.757717 | 3 | 0 | 3 |
| PDCD6 | SLC25A39 | 0.757494 | 3 | 0 | 3 |
| PDCD6 | CBLC | 0.737237 | 3 | 0 | 3 |
| PDCD6 | MRPL51 | 0.737189 | 3 | 0 | 3 |
| PDCD6 | XPNPEP1 | 0.734897 | 4 | 0 | 4 |
| PDCD6 | TMEM69 | 0.731281 | 3 | 0 | 3 |
| PDCD6 | HM13 | 0.718333 | 3 | 0 | 3 |
| PDCD6 | COX16 | 0.712743 | 3 | 0 | 3 |
| PDCD6 | OSTC | 0.706797 | 3 | 0 | 3 |
| PDCD6 | ACBD5 | 0.705002 | 3 | 0 | 3 |
| PDCD6 | MAPK8 | 0.704319 | 3 | 0 | 3 |
| PDCD6 | MGAT3 | 0.693291 | 3 | 0 | 3 |
| PDCD6 | ZNF101 | 0.688197 | 4 | 0 | 3 |
| PDCD6 | TM2D2 | 0.678612 | 4 | 0 | 3 |
| PDCD6 | RALGAPA2 | 0.677558 | 3 | 0 | 3 |
| PDCD6 | GK5 | 0.676073 | 4 | 0 | 4 |
For details and further investigation, click here
