| Full name: mitogen-activated protein kinase kinase kinase 13 | Alias Symbol: LZK|MEKK13 | ||
| Type: protein-coding gene | Cytoband: 3q27.2 | ||
| Entrez ID: 9175 | HGNC ID: HGNC:6852 | Ensembl Gene: ENSG00000073803 | OMIM ID: 604915 |
| Drug and gene relationship at DGIdb | |||
MAP3K13 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04010 | MAPK signaling pathway |
Expression of MAP3K13:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MAP3K13 | 9175 | 226190_at | 0.6517 | 0.1963 | |
| GSE20347 | MAP3K13 | 9175 | 206249_at | 0.0163 | 0.9412 | |
| GSE23400 | MAP3K13 | 9175 | 206249_at | -0.0385 | 0.3135 | |
| GSE26886 | MAP3K13 | 9175 | 226190_at | 1.2209 | 0.0000 | |
| GSE29001 | MAP3K13 | 9175 | 206249_at | 0.0134 | 0.9595 | |
| GSE38129 | MAP3K13 | 9175 | 206249_at | -0.0095 | 0.9556 | |
| GSE45670 | MAP3K13 | 9175 | 226190_at | 0.7084 | 0.0024 | |
| GSE53622 | MAP3K13 | 9175 | 38370 | 0.6295 | 0.0000 | |
| GSE53624 | MAP3K13 | 9175 | 38370 | 0.7070 | 0.0000 | |
| GSE63941 | MAP3K13 | 9175 | 226190_at | 2.2612 | 0.0006 | |
| GSE77861 | MAP3K13 | 9175 | 226190_at | 0.6609 | 0.0610 | |
| GSE97050 | MAP3K13 | A_19_P00316326 | 0.5234 | 0.0903 | ||
| SRP007169 | MAP3K13 | 9175 | RNAseq | 0.0959 | 0.8013 | |
| SRP008496 | MAP3K13 | 9175 | RNAseq | 0.5379 | 0.0431 | |
| SRP064894 | MAP3K13 | 9175 | RNAseq | 0.4302 | 0.0446 | |
| SRP133303 | MAP3K13 | 9175 | RNAseq | 0.7761 | 0.0036 | |
| SRP159526 | MAP3K13 | 9175 | RNAseq | 1.1378 | 0.0002 | |
| SRP193095 | MAP3K13 | 9175 | RNAseq | 0.4225 | 0.0021 | |
| SRP219564 | MAP3K13 | 9175 | RNAseq | -0.0109 | 0.9759 | |
| TCGA | MAP3K13 | 9175 | RNAseq | -0.2359 | 0.0932 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by MAP3K13 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MAP3K13:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MAP3K13 | 9175 | 25 | 0 | 5 | |
| GSE20123 | MAP3K13 | 9175 | 25 | 0 | 5 | |
| GSE43470 | MAP3K13 | 9175 | 23 | 0 | 20 | |
| GSE46452 | MAP3K13 | 9175 | 19 | 1 | 39 | |
| GSE47630 | MAP3K13 | 9175 | 27 | 2 | 11 | |
| GSE54993 | MAP3K13 | 9175 | 1 | 19 | 50 | |
| GSE54994 | MAP3K13 | 9175 | 40 | 0 | 13 | |
| GSE60625 | MAP3K13 | 9175 | 0 | 6 | 5 | |
| GSE74703 | MAP3K13 | 9175 | 20 | 0 | 16 | |
| GSE74704 | MAP3K13 | 9175 | 17 | 0 | 3 | |
| TCGA | MAP3K13 | 9175 | 77 | 0 | 19 |
Total number of gains: 274; Total number of losses: 28; Total Number of normals: 186.
Somatic mutations of MAP3K13:
Generating mutation plots.
Highly correlated genes for MAP3K13:
Showing top 20/1123 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MAP3K13 | METAP1D | 0.847458 | 3 | 0 | 3 |
| MAP3K13 | DVL3 | 0.801404 | 6 | 0 | 6 |
| MAP3K13 | ALG3 | 0.788976 | 7 | 0 | 7 |
| MAP3K13 | SEMA3C | 0.787372 | 3 | 0 | 3 |
| MAP3K13 | RPS21 | 0.783634 | 3 | 0 | 3 |
| MAP3K13 | PACS1 | 0.775621 | 3 | 0 | 3 |
| MAP3K13 | RILPL2 | 0.772099 | 3 | 0 | 3 |
| MAP3K13 | FLOT2 | 0.772001 | 3 | 0 | 3 |
| MAP3K13 | SULT1A1 | 0.762167 | 3 | 0 | 3 |
| MAP3K13 | POLR2H | 0.762145 | 8 | 0 | 7 |
| MAP3K13 | NSMCE4A | 0.753985 | 3 | 0 | 3 |
| MAP3K13 | ZBTB8A | 0.753411 | 3 | 0 | 3 |
| MAP3K13 | RPRD2 | 0.752499 | 3 | 0 | 3 |
| MAP3K13 | NCBP2 | 0.75224 | 5 | 0 | 4 |
| MAP3K13 | NAP1L4 | 0.749967 | 3 | 0 | 3 |
| MAP3K13 | ZHX2 | 0.749562 | 3 | 0 | 3 |
| MAP3K13 | PRR12 | 0.74632 | 3 | 0 | 3 |
| MAP3K13 | PSMD2 | 0.740574 | 7 | 0 | 7 |
| MAP3K13 | PYCR2 | 0.740241 | 3 | 0 | 3 |
| MAP3K13 | SOCS7 | 0.733694 | 3 | 0 | 3 |
For details and further investigation, click here
