| Full name: secreted protein acidic and cysteine rich | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 5q33.1 | ||
| Entrez ID: 6678 | HGNC ID: HGNC:11219 | Ensembl Gene: ENSG00000113140 | OMIM ID: 182120 |
| Drug and gene relationship at DGIdb | |||
Expression of SPARC:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SPARC | 6678 | 200665_s_at | 0.9807 | 0.2169 | |
| GSE20347 | SPARC | 6678 | 200665_s_at | 2.3313 | 0.0000 | |
| GSE23400 | SPARC | 6678 | 200665_s_at | 1.8673 | 0.0000 | |
| GSE26886 | SPARC | 6678 | 200665_s_at | 1.9606 | 0.0001 | |
| GSE29001 | SPARC | 6678 | 200665_s_at | 1.8448 | 0.0011 | |
| GSE38129 | SPARC | 6678 | 200665_s_at | 2.1431 | 0.0000 | |
| GSE45670 | SPARC | 6678 | 200665_s_at | 0.5238 | 0.3267 | |
| GSE53622 | SPARC | 6678 | 50458 | 2.4932 | 0.0000 | |
| GSE53624 | SPARC | 6678 | 50458 | 2.7114 | 0.0000 | |
| GSE63941 | SPARC | 6678 | 200665_s_at | -8.0803 | 0.0003 | |
| GSE77861 | SPARC | 6678 | 200665_s_at | 1.7367 | 0.0257 | |
| GSE97050 | SPARC | 6678 | A_33_P3382924 | 0.6668 | 0.2810 | |
| SRP007169 | SPARC | 6678 | RNAseq | 4.3106 | 0.0000 | |
| SRP008496 | SPARC | 6678 | RNAseq | 4.8186 | 0.0000 | |
| SRP064894 | SPARC | 6678 | RNAseq | 2.9050 | 0.0000 | |
| SRP133303 | SPARC | 6678 | RNAseq | 2.8903 | 0.0000 | |
| SRP159526 | SPARC | 6678 | RNAseq | 1.2728 | 0.0000 | |
| SRP193095 | SPARC | 6678 | RNAseq | 3.0362 | 0.0000 | |
| SRP219564 | SPARC | 6678 | RNAseq | 1.9595 | 0.0062 | |
| TCGA | SPARC | 6678 | RNAseq | 0.2833 | 0.0011 |
Upregulated datasets: 15; Downregulated datasets: 1.
Survival by SPARC expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SPARC:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SPARC | 6678 | 1 | 12 | 17 | |
| GSE20123 | SPARC | 6678 | 1 | 12 | 17 | |
| GSE43470 | SPARC | 6678 | 2 | 10 | 31 | |
| GSE46452 | SPARC | 6678 | 0 | 27 | 32 | |
| GSE47630 | SPARC | 6678 | 0 | 20 | 20 | |
| GSE54993 | SPARC | 6678 | 9 | 1 | 60 | |
| GSE54994 | SPARC | 6678 | 2 | 16 | 35 | |
| GSE60625 | SPARC | 6678 | 0 | 0 | 11 | |
| GSE74703 | SPARC | 6678 | 2 | 8 | 26 | |
| GSE74704 | SPARC | 6678 | 1 | 7 | 12 | |
| TCGA | SPARC | 6678 | 6 | 37 | 53 |
Total number of gains: 24; Total number of losses: 150; Total Number of normals: 314.
Somatic mutations of SPARC:
Generating mutation plots.
Highly correlated genes for SPARC:
Showing top 20/1216 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SPARC | COL6A3 | 0.901158 | 13 | 0 | 13 |
| SPARC | VCAN | 0.893084 | 13 | 0 | 13 |
| SPARC | COL3A1 | 0.891491 | 13 | 0 | 12 |
| SPARC | COL1A2 | 0.882366 | 13 | 0 | 13 |
| SPARC | COL5A2 | 0.870524 | 13 | 0 | 13 |
| SPARC | POSTN | 0.87007 | 13 | 0 | 12 |
| SPARC | COL5A1 | 0.863518 | 13 | 0 | 13 |
| SPARC | CTSK | 0.856576 | 13 | 0 | 13 |
| SPARC | THY1 | 0.842741 | 13 | 0 | 13 |
| SPARC | COL12A1 | 0.842311 | 9 | 0 | 9 |
| SPARC | FN1 | 0.8409 | 12 | 0 | 12 |
| SPARC | CALU | 0.835661 | 12 | 0 | 12 |
| SPARC | COL1A1 | 0.833224 | 12 | 0 | 11 |
| SPARC | SULF1 | 0.830867 | 13 | 0 | 13 |
| SPARC | HTRA1 | 0.823078 | 13 | 0 | 13 |
| SPARC | FAP | 0.820787 | 11 | 0 | 10 |
| SPARC | PCOLCE | 0.819128 | 13 | 0 | 13 |
| SPARC | LUM | 0.816119 | 13 | 0 | 13 |
| SPARC | MMP2 | 0.811863 | 12 | 0 | 11 |
| SPARC | CDH11 | 0.810131 | 13 | 0 | 13 |
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