| Full name: collagen type VI alpha 3 chain | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 2q37.3 | ||
| Entrez ID: 1293 | HGNC ID: HGNC:2213 | Ensembl Gene: ENSG00000163359 | OMIM ID: 120250 |
| Related drugs: COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN... [more] | |||
COL6A3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04151 | PI3K-Akt signaling pathway | |
| hsa04510 | Focal adhesion |
Expression of COL6A3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | COL6A3 | 1293 | 201438_at | 0.7182 | 0.3373 | |
| GSE20347 | COL6A3 | 1293 | 201438_at | 2.0034 | 0.0000 | |
| GSE23400 | COL6A3 | 1293 | 201438_at | 1.5061 | 0.0000 | |
| GSE26886 | COL6A3 | 1293 | 201438_at | 2.8350 | 0.0000 | |
| GSE29001 | COL6A3 | 1293 | 201438_at | 1.5592 | 0.0032 | |
| GSE38129 | COL6A3 | 1293 | 201438_at | 1.7543 | 0.0000 | |
| GSE45670 | COL6A3 | 1293 | 201438_at | -0.0696 | 0.9330 | |
| GSE53622 | COL6A3 | 1293 | 67167 | 1.7100 | 0.0000 | |
| GSE53624 | COL6A3 | 1293 | 67167 | 2.0181 | 0.0000 | |
| GSE63941 | COL6A3 | 1293 | 201438_at | -8.9692 | 0.0000 | |
| GSE77861 | COL6A3 | 1293 | 201438_at | 2.8513 | 0.0071 | |
| GSE97050 | COL6A3 | 1293 | A_33_P3210488 | 2.0564 | 0.0465 | |
| SRP007169 | COL6A3 | 1293 | RNAseq | 4.8207 | 0.0000 | |
| SRP008496 | COL6A3 | 1293 | RNAseq | 5.0477 | 0.0000 | |
| SRP064894 | COL6A3 | 1293 | RNAseq | 2.2986 | 0.0000 | |
| SRP133303 | COL6A3 | 1293 | RNAseq | 2.1171 | 0.0000 | |
| SRP159526 | COL6A3 | 1293 | RNAseq | 1.1352 | 0.0002 | |
| SRP193095 | COL6A3 | 1293 | RNAseq | 3.9157 | 0.0000 | |
| SRP219564 | COL6A3 | 1293 | RNAseq | 1.6202 | 0.0122 | |
| TCGA | COL6A3 | 1293 | RNAseq | 0.2330 | 0.0310 |
Upregulated datasets: 16; Downregulated datasets: 1.
Survival by COL6A3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of COL6A3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | COL6A3 | 1293 | 1 | 11 | 18 | |
| GSE20123 | COL6A3 | 1293 | 1 | 11 | 18 | |
| GSE43470 | COL6A3 | 1293 | 1 | 9 | 33 | |
| GSE46452 | COL6A3 | 1293 | 0 | 5 | 54 | |
| GSE47630 | COL6A3 | 1293 | 4 | 5 | 31 | |
| GSE54993 | COL6A3 | 1293 | 3 | 2 | 65 | |
| GSE54994 | COL6A3 | 1293 | 8 | 10 | 35 | |
| GSE60625 | COL6A3 | 1293 | 0 | 3 | 8 | |
| GSE74703 | COL6A3 | 1293 | 1 | 7 | 28 | |
| GSE74704 | COL6A3 | 1293 | 1 | 5 | 14 | |
| TCGA | COL6A3 | 1293 | 11 | 27 | 58 |
Total number of gains: 31; Total number of losses: 95; Total Number of normals: 362.
Somatic mutations of COL6A3:
Generating mutation plots.
Highly correlated genes for COL6A3:
Showing top 20/1101 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| COL6A3 | COL3A1 | 0.93894 | 13 | 0 | 13 |
| COL6A3 | VCAN | 0.919335 | 13 | 0 | 13 |
| COL6A3 | COL1A2 | 0.908036 | 13 | 0 | 13 |
| COL6A3 | SPARC | 0.901158 | 13 | 0 | 13 |
| COL6A3 | COL5A2 | 0.891114 | 13 | 0 | 13 |
| COL6A3 | CTSK | 0.885522 | 13 | 0 | 13 |
| COL6A3 | POSTN | 0.88196 | 13 | 0 | 13 |
| COL6A3 | COL1A1 | 0.876682 | 12 | 0 | 12 |
| COL6A3 | COL5A1 | 0.865177 | 13 | 0 | 13 |
| COL6A3 | FN1 | 0.857695 | 12 | 0 | 12 |
| COL6A3 | THY1 | 0.856881 | 13 | 0 | 13 |
| COL6A3 | PCOLCE | 0.854931 | 13 | 0 | 13 |
| COL6A3 | LUM | 0.850557 | 13 | 0 | 13 |
| COL6A3 | CDH11 | 0.844152 | 13 | 0 | 13 |
| COL6A3 | FAP | 0.837233 | 11 | 0 | 11 |
| COL6A3 | SULF1 | 0.835127 | 13 | 0 | 13 |
| COL6A3 | MMP2 | 0.833866 | 12 | 0 | 11 |
| COL6A3 | THBS2 | 0.82832 | 13 | 0 | 13 |
| COL6A3 | COL12A1 | 0.824193 | 9 | 0 | 9 |
| COL6A3 | COL6A1 | 0.823937 | 13 | 0 | 13 |
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