| Full name: matrix metallopeptidase 16 | Alias Symbol: MT3-MMP|DKFZp761D112 | ||
| Type: protein-coding gene | Cytoband: 8q21.3 | ||
| Entrez ID: 4325 | HGNC ID: HGNC:7162 | Ensembl Gene: ENSG00000156103 | OMIM ID: 602262 |
| Drug and gene relationship at DGIdb | |||
Expression of MMP16:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MMP16 | 4325 | 223614_at | 0.4850 | 0.6242 | |
| GSE20347 | MMP16 | 4325 | 207013_s_at | -0.0044 | 0.9686 | |
| GSE23400 | MMP16 | 4325 | 207013_s_at | -0.1007 | 0.0008 | |
| GSE26886 | MMP16 | 4325 | 207013_s_at | -0.1949 | 0.1908 | |
| GSE29001 | MMP16 | 4325 | 207013_s_at | -0.0752 | 0.6317 | |
| GSE38129 | MMP16 | 4325 | 207013_s_at | -0.1463 | 0.1080 | |
| GSE45670 | MMP16 | 4325 | 223614_at | -0.4386 | 0.3576 | |
| GSE53622 | MMP16 | 4325 | 14652 | 0.9356 | 0.0000 | |
| GSE53624 | MMP16 | 4325 | 54560 | 1.1065 | 0.0000 | |
| GSE63941 | MMP16 | 4325 | 207013_s_at | 0.0211 | 0.9251 | |
| GSE77861 | MMP16 | 4325 | 207013_s_at | -0.1060 | 0.2415 | |
| GSE97050 | MMP16 | 4325 | A_24_P235400 | 0.3388 | 0.2330 | |
| SRP007169 | MMP16 | 4325 | RNAseq | 4.0875 | 0.0000 | |
| SRP064894 | MMP16 | 4325 | RNAseq | 1.3081 | 0.0008 | |
| SRP133303 | MMP16 | 4325 | RNAseq | 1.4422 | 0.0023 | |
| SRP159526 | MMP16 | 4325 | RNAseq | 1.8865 | 0.0092 | |
| SRP219564 | MMP16 | 4325 | RNAseq | 1.3198 | 0.1593 | |
| TCGA | MMP16 | 4325 | RNAseq | -0.1250 | 0.6663 |
Upregulated datasets: 5; Downregulated datasets: 0.
Survival by MMP16 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MMP16:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MMP16 | 4325 | 14 | 1 | 15 | |
| GSE20123 | MMP16 | 4325 | 16 | 1 | 13 | |
| GSE43470 | MMP16 | 4325 | 19 | 1 | 23 | |
| GSE46452 | MMP16 | 4325 | 22 | 0 | 37 | |
| GSE47630 | MMP16 | 4325 | 23 | 0 | 17 | |
| GSE54993 | MMP16 | 4325 | 0 | 20 | 50 | |
| GSE54994 | MMP16 | 4325 | 33 | 1 | 19 | |
| GSE60625 | MMP16 | 4325 | 0 | 4 | 7 | |
| GSE74703 | MMP16 | 4325 | 16 | 1 | 19 | |
| GSE74704 | MMP16 | 4325 | 10 | 0 | 10 | |
| TCGA | MMP16 | 4325 | 53 | 2 | 41 |
Total number of gains: 206; Total number of losses: 31; Total Number of normals: 251.
Somatic mutations of MMP16:
Generating mutation plots.
Highly correlated genes for MMP16:
Showing top 20/361 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MMP16 | KCNJ14 | 0.759936 | 3 | 0 | 3 |
| MMP16 | NRSN2 | 0.732829 | 3 | 0 | 3 |
| MMP16 | SNX15 | 0.730992 | 4 | 0 | 4 |
| MMP16 | ZNF358 | 0.728416 | 3 | 0 | 3 |
| MMP16 | FKBP7 | 0.728257 | 5 | 0 | 5 |
| MMP16 | SPON2 | 0.724111 | 3 | 0 | 3 |
| MMP16 | RFTN2 | 0.711862 | 3 | 0 | 3 |
| MMP16 | RAB34 | 0.711754 | 3 | 0 | 3 |
| MMP16 | APH1B | 0.701978 | 5 | 0 | 5 |
| MMP16 | CMTM3 | 0.700611 | 5 | 0 | 5 |
| MMP16 | C7orf50 | 0.693637 | 3 | 0 | 3 |
| MMP16 | KCNQ1DN | 0.684133 | 4 | 0 | 4 |
| MMP16 | ALG12 | 0.681854 | 3 | 0 | 3 |
| MMP16 | BBS12 | 0.679055 | 4 | 0 | 3 |
| MMP16 | DUX1 | 0.678283 | 5 | 0 | 5 |
| MMP16 | LRRC8C | 0.676607 | 3 | 0 | 3 |
| MMP16 | MLXIPL | 0.674415 | 4 | 0 | 4 |
| MMP16 | TNFRSF4 | 0.674084 | 3 | 0 | 3 |
| MMP16 | MEX3B | 0.673787 | 6 | 0 | 5 |
| MMP16 | TM4SF18 | 0.673777 | 6 | 0 | 5 |
For details and further investigation, click here
