| Full name: transmembrane 4 L six family member 18 | Alias Symbol: L6D | ||
| Type: protein-coding gene | Cytoband: 3q25.1 | ||
| Entrez ID: 116441 | HGNC ID: HGNC:25181 | Ensembl Gene: ENSG00000163762 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Expression of TM4SF18:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TM4SF18 | 116441 | 228489_at | -0.0808 | 0.9135 | |
| GSE26886 | TM4SF18 | 116441 | 228489_at | -0.3450 | 0.0636 | |
| GSE45670 | TM4SF18 | 116441 | 230061_at | -0.3675 | 0.4500 | |
| GSE53622 | TM4SF18 | 116441 | 81331 | -0.0165 | 0.9169 | |
| GSE53624 | TM4SF18 | 116441 | 81331 | 0.1202 | 0.5602 | |
| GSE63941 | TM4SF18 | 116441 | 228489_at | 0.1228 | 0.4151 | |
| GSE77861 | TM4SF18 | 116441 | 228489_at | -0.0645 | 0.7423 | |
| GSE97050 | TM4SF18 | 116441 | A_24_P120251 | 0.2676 | 0.4352 | |
| SRP007169 | TM4SF18 | 116441 | RNAseq | 0.6197 | 0.3098 | |
| SRP064894 | TM4SF18 | 116441 | RNAseq | 0.4994 | 0.0858 | |
| SRP133303 | TM4SF18 | 116441 | RNAseq | 0.0266 | 0.9091 | |
| SRP159526 | TM4SF18 | 116441 | RNAseq | -0.0379 | 0.9385 | |
| SRP193095 | TM4SF18 | 116441 | RNAseq | 0.5186 | 0.0098 | |
| SRP219564 | TM4SF18 | 116441 | RNAseq | -0.0417 | 0.9510 | |
| TCGA | TM4SF18 | 116441 | RNAseq | -0.5025 | 0.0063 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by TM4SF18 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TM4SF18:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TM4SF18 | 116441 | 22 | 0 | 8 | |
| GSE20123 | TM4SF18 | 116441 | 22 | 0 | 8 | |
| GSE43470 | TM4SF18 | 116441 | 23 | 0 | 20 | |
| GSE46452 | TM4SF18 | 116441 | 18 | 2 | 39 | |
| GSE47630 | TM4SF18 | 116441 | 19 | 3 | 18 | |
| GSE54993 | TM4SF18 | 116441 | 1 | 10 | 59 | |
| GSE54994 | TM4SF18 | 116441 | 37 | 1 | 15 | |
| GSE60625 | TM4SF18 | 116441 | 0 | 6 | 5 | |
| GSE74703 | TM4SF18 | 116441 | 20 | 0 | 16 | |
| GSE74704 | TM4SF18 | 116441 | 15 | 0 | 5 | |
| TCGA | TM4SF18 | 116441 | 71 | 1 | 24 |
Total number of gains: 248; Total number of losses: 23; Total Number of normals: 217.
Somatic mutations of TM4SF18:
Generating mutation plots.
Highly correlated genes for TM4SF18:
Showing top 20/290 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TM4SF18 | PTPRG | 0.751235 | 4 | 0 | 4 |
| TM4SF18 | NIT1 | 0.749076 | 3 | 0 | 3 |
| TM4SF18 | RAD50 | 0.746568 | 3 | 0 | 3 |
| TM4SF18 | C19orf38 | 0.746048 | 3 | 0 | 3 |
| TM4SF18 | TYW3 | 0.745803 | 3 | 0 | 3 |
| TM4SF18 | HBEGF | 0.742487 | 3 | 0 | 3 |
| TM4SF18 | PRDX3 | 0.735491 | 4 | 0 | 3 |
| TM4SF18 | ZFPL1 | 0.725403 | 3 | 0 | 3 |
| TM4SF18 | TIE1 | 0.721601 | 6 | 0 | 5 |
| TM4SF18 | RDX | 0.714688 | 3 | 0 | 3 |
| TM4SF18 | NMNAT2 | 0.712469 | 4 | 0 | 3 |
| TM4SF18 | RFTN2 | 0.706108 | 3 | 0 | 3 |
| TM4SF18 | PIGK | 0.705503 | 4 | 0 | 4 |
| TM4SF18 | GPR65 | 0.705247 | 4 | 0 | 4 |
| TM4SF18 | FAM151B | 0.703859 | 3 | 0 | 3 |
| TM4SF18 | SNTB2 | 0.701802 | 3 | 0 | 3 |
| TM4SF18 | CCDC126 | 0.699452 | 3 | 0 | 3 |
| TM4SF18 | FLI1 | 0.696266 | 5 | 0 | 4 |
| TM4SF18 | KDR | 0.696242 | 6 | 0 | 5 |
| TM4SF18 | RAPGEF4 | 0.6917 | 3 | 0 | 3 |
For details and further investigation, click here
