| Full name: ALG12 alpha-1,6-mannosyltransferase | Alias Symbol: ECM39|CDG1G | ||
| Type: protein-coding gene | Cytoband: 22q13.33 | ||
| Entrez ID: 79087 | HGNC ID: HGNC:19358 | Ensembl Gene: ENSG00000182858 | OMIM ID: 607144 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of ALG12:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ALG12 | 79087 | 218444_at | 0.1501 | 0.5283 | |
| GSE20347 | ALG12 | 79087 | 218444_at | -0.0225 | 0.8421 | |
| GSE23400 | ALG12 | 79087 | 218444_at | -0.1776 | 0.0001 | |
| GSE26886 | ALG12 | 79087 | 218444_at | 0.4006 | 0.0148 | |
| GSE29001 | ALG12 | 79087 | 218444_at | -0.1795 | 0.2076 | |
| GSE38129 | ALG12 | 79087 | 218444_at | -0.0584 | 0.5821 | |
| GSE45670 | ALG12 | 79087 | 218444_at | -0.0095 | 0.9496 | |
| GSE63941 | ALG12 | 79087 | 218444_at | 0.6288 | 0.0687 | |
| GSE77861 | ALG12 | 79087 | 218444_at | 0.0687 | 0.5084 | |
| GSE97050 | ALG12 | 79087 | A_23_P60718 | -0.0332 | 0.9294 | |
| SRP007169 | ALG12 | 79087 | RNAseq | -0.0384 | 0.9210 | |
| SRP008496 | ALG12 | 79087 | RNAseq | -0.5008 | 0.0941 | |
| SRP064894 | ALG12 | 79087 | RNAseq | 0.6860 | 0.0006 | |
| SRP133303 | ALG12 | 79087 | RNAseq | 0.1032 | 0.5433 | |
| SRP159526 | ALG12 | 79087 | RNAseq | 0.5257 | 0.0154 | |
| SRP193095 | ALG12 | 79087 | RNAseq | 0.1384 | 0.1742 | |
| SRP219564 | ALG12 | 79087 | RNAseq | 0.6253 | 0.0539 | |
| TCGA | ALG12 | 79087 | RNAseq | -0.0537 | 0.2979 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by ALG12 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of ALG12:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ALG12 | 79087 | 3 | 8 | 19 | |
| GSE20123 | ALG12 | 79087 | 3 | 8 | 19 | |
| GSE43470 | ALG12 | 79087 | 2 | 8 | 33 | |
| GSE46452 | ALG12 | 79087 | 31 | 2 | 26 | |
| GSE47630 | ALG12 | 79087 | 9 | 4 | 27 | |
| GSE54993 | ALG12 | 79087 | 4 | 6 | 60 | |
| GSE54994 | ALG12 | 79087 | 11 | 8 | 34 | |
| GSE60625 | ALG12 | 79087 | 5 | 0 | 6 | |
| GSE74703 | ALG12 | 79087 | 2 | 6 | 28 | |
| GSE74704 | ALG12 | 79087 | 1 | 4 | 15 | |
| TCGA | ALG12 | 79087 | 26 | 16 | 54 |
Total number of gains: 97; Total number of losses: 70; Total Number of normals: 321.
Somatic mutations of ALG12:
Generating mutation plots.
Highly correlated genes for ALG12:
Showing top 20/310 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ALG12 | ATF7 | 0.781976 | 3 | 0 | 3 |
| ALG12 | ZNF324B | 0.780324 | 3 | 0 | 3 |
| ALG12 | HES6 | 0.760167 | 4 | 0 | 4 |
| ALG12 | CDH24 | 0.755064 | 3 | 0 | 3 |
| ALG12 | NOXO1 | 0.734214 | 3 | 0 | 3 |
| ALG12 | MRPL47 | 0.733745 | 3 | 0 | 3 |
| ALG12 | RTN4R | 0.714054 | 4 | 0 | 4 |
| ALG12 | LIMD2 | 0.709045 | 4 | 0 | 4 |
| ALG12 | PHRF1 | 0.70791 | 3 | 0 | 3 |
| ALG12 | C3orf33 | 0.706152 | 3 | 0 | 3 |
| ALG12 | TBC1D9B | 0.701583 | 3 | 0 | 3 |
| ALG12 | HES4 | 0.699861 | 3 | 0 | 3 |
| ALG12 | NME4 | 0.699211 | 3 | 0 | 3 |
| ALG12 | SLC9A1 | 0.695883 | 3 | 0 | 3 |
| ALG12 | APLP1 | 0.691418 | 3 | 0 | 3 |
| ALG12 | STRADA | 0.689368 | 3 | 0 | 3 |
| ALG12 | ACIN1 | 0.687318 | 3 | 0 | 3 |
| ALG12 | MZF1 | 0.68713 | 3 | 0 | 3 |
| ALG12 | OGFOD1 | 0.685591 | 3 | 0 | 3 |
| ALG12 | ENTPD2 | 0.683249 | 5 | 0 | 5 |
For details and further investigation, click here
