| Full name: TNF receptor superfamily member 4 | Alias Symbol: ACT35|OX40|CD134 | ||
| Type: protein-coding gene | Cytoband: 1p36.33 | ||
| Entrez ID: 7293 | HGNC ID: HGNC:11918 | Ensembl Gene: ENSG00000186827 | OMIM ID: 600315 |
| Drug and gene relationship at DGIdb | |||
Expression of TNFRSF4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TNFRSF4 | 7293 | 214228_x_at | 0.1944 | 0.6150 | |
| GSE20347 | TNFRSF4 | 7293 | 214228_x_at | 0.0546 | 0.5342 | |
| GSE23400 | TNFRSF4 | 7293 | 214228_x_at | -0.0275 | 0.4884 | |
| GSE26886 | TNFRSF4 | 7293 | 214228_x_at | 0.4355 | 0.0036 | |
| GSE29001 | TNFRSF4 | 7293 | 208023_at | -0.1381 | 0.3778 | |
| GSE38129 | TNFRSF4 | 7293 | 214228_x_at | 0.1716 | 0.1144 | |
| GSE45670 | TNFRSF4 | 7293 | 214228_x_at | 0.2596 | 0.1325 | |
| GSE53622 | TNFRSF4 | 7293 | 86195 | 1.0661 | 0.0000 | |
| GSE53624 | TNFRSF4 | 7293 | 86195 | 1.3542 | 0.0000 | |
| GSE63941 | TNFRSF4 | 7293 | 214228_x_at | 0.3022 | 0.1013 | |
| GSE77861 | TNFRSF4 | 7293 | 214228_x_at | 0.0563 | 0.7024 | |
| GSE97050 | TNFRSF4 | 7293 | A_33_P3286157 | 0.1601 | 0.7327 | |
| SRP064894 | TNFRSF4 | 7293 | RNAseq | 2.7939 | 0.0000 | |
| SRP133303 | TNFRSF4 | 7293 | RNAseq | 1.1683 | 0.0000 | |
| SRP159526 | TNFRSF4 | 7293 | RNAseq | 0.5635 | 0.0786 | |
| SRP219564 | TNFRSF4 | 7293 | RNAseq | 1.2430 | 0.0154 | |
| TCGA | TNFRSF4 | 7293 | RNAseq | 1.1831 | 0.0000 |
Upregulated datasets: 6; Downregulated datasets: 0.
Survival by TNFRSF4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TNFRSF4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TNFRSF4 | 7293 | 3 | 7 | 20 | |
| GSE20123 | TNFRSF4 | 7293 | 3 | 6 | 21 | |
| GSE43470 | TNFRSF4 | 7293 | 3 | 5 | 35 | |
| GSE46452 | TNFRSF4 | 7293 | 7 | 1 | 51 | |
| GSE47630 | TNFRSF4 | 7293 | 8 | 4 | 28 | |
| GSE54993 | TNFRSF4 | 7293 | 2 | 2 | 66 | |
| GSE54994 | TNFRSF4 | 7293 | 15 | 2 | 36 | |
| GSE60625 | TNFRSF4 | 7293 | 0 | 0 | 11 | |
| GSE74703 | TNFRSF4 | 7293 | 3 | 3 | 30 | |
| GSE74704 | TNFRSF4 | 7293 | 3 | 0 | 17 | |
| TCGA | TNFRSF4 | 7293 | 14 | 20 | 62 |
Total number of gains: 61; Total number of losses: 50; Total Number of normals: 377.
Somatic mutations of TNFRSF4:
Generating mutation plots.
Highly correlated genes for TNFRSF4:
Showing top 20/805 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TNFRSF4 | GABRR2 | 0.785435 | 3 | 0 | 3 |
| TNFRSF4 | CATSPER1 | 0.764147 | 3 | 0 | 3 |
| TNFRSF4 | LIPF | 0.746965 | 3 | 0 | 3 |
| TNFRSF4 | KTI12 | 0.742878 | 3 | 0 | 3 |
| TNFRSF4 | GYG2 | 0.735746 | 3 | 0 | 3 |
| TNFRSF4 | LDB1 | 0.731195 | 3 | 0 | 3 |
| TNFRSF4 | ABHD16B | 0.724036 | 3 | 0 | 3 |
| TNFRSF4 | LMO1 | 0.723781 | 4 | 0 | 4 |
| TNFRSF4 | SUCNR1 | 0.72363 | 4 | 0 | 4 |
| TNFRSF4 | SNAI3 | 0.722927 | 4 | 0 | 3 |
| TNFRSF4 | ZNF358 | 0.721256 | 3 | 0 | 3 |
| TNFRSF4 | SIX5 | 0.706064 | 4 | 0 | 4 |
| TNFRSF4 | ITGB3 | 0.704441 | 4 | 0 | 3 |
| TNFRSF4 | KCNIP2-AS1 | 0.701119 | 4 | 0 | 3 |
| TNFRSF4 | CYSLTR2 | 0.69006 | 4 | 0 | 3 |
| TNFRSF4 | MRPL38 | 0.688106 | 3 | 0 | 3 |
| TNFRSF4 | LRP1 | 0.68665 | 3 | 0 | 3 |
| TNFRSF4 | SAMD4B | 0.686145 | 3 | 0 | 3 |
| TNFRSF4 | FNDC8 | 0.684864 | 5 | 0 | 4 |
| TNFRSF4 | IL2RB | 0.684015 | 6 | 0 | 6 |
For details and further investigation, click here
