| Full name: matrix metallopeptidase 21 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 10q26.2 | ||
| Entrez ID: 118856 | HGNC ID: HGNC:14357 | Ensembl Gene: ENSG00000154485 | OMIM ID: 608416 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of MMP21:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MMP21 | 118856 | 1552592_at | -0.0790 | 0.7089 | |
| GSE26886 | MMP21 | 118856 | 1552592_at | 0.0427 | 0.5675 | |
| GSE45670 | MMP21 | 118856 | 1552592_at | 0.0256 | 0.7609 | |
| GSE53622 | MMP21 | 118856 | 26607 | -0.1571 | 0.1922 | |
| GSE53624 | MMP21 | 118856 | 26607 | -0.0647 | 0.3681 | |
| GSE63941 | MMP21 | 118856 | 1552592_at | -0.0829 | 0.4327 | |
| GSE77861 | MMP21 | 118856 | 1552592_at | 0.0670 | 0.4163 | |
| GSE97050 | MMP21 | 118856 | A_23_P24211 | -0.3408 | 0.2575 | |
| TCGA | MMP21 | 118856 | RNAseq | -2.4828 | 0.0001 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by MMP21 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MMP21:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MMP21 | 118856 | 2 | 6 | 22 | |
| GSE20123 | MMP21 | 118856 | 2 | 6 | 22 | |
| GSE43470 | MMP21 | 118856 | 0 | 10 | 33 | |
| GSE46452 | MMP21 | 118856 | 0 | 11 | 48 | |
| GSE47630 | MMP21 | 118856 | 2 | 14 | 24 | |
| GSE54993 | MMP21 | 118856 | 8 | 1 | 61 | |
| GSE54994 | MMP21 | 118856 | 1 | 9 | 43 | |
| GSE60625 | MMP21 | 118856 | 0 | 0 | 11 | |
| GSE74703 | MMP21 | 118856 | 0 | 6 | 30 | |
| GSE74704 | MMP21 | 118856 | 2 | 2 | 16 | |
| TCGA | MMP21 | 118856 | 7 | 27 | 62 |
Total number of gains: 24; Total number of losses: 92; Total Number of normals: 372.
Somatic mutations of MMP21:
Generating mutation plots.
Highly correlated genes for MMP21:
Showing top 20/95 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MMP21 | KCNF1 | 0.771713 | 3 | 0 | 3 |
| MMP21 | OR2D2 | 0.76613 | 3 | 0 | 3 |
| MMP21 | FHAD1 | 0.759998 | 3 | 0 | 3 |
| MMP21 | TRIM10 | 0.730123 | 4 | 0 | 4 |
| MMP21 | TDRD1 | 0.725078 | 3 | 0 | 3 |
| MMP21 | SMCP | 0.717235 | 3 | 0 | 3 |
| MMP21 | PTPRR | 0.716148 | 3 | 0 | 3 |
| MMP21 | PNLIPRP1 | 0.713304 | 3 | 0 | 3 |
| MMP21 | PRAMEF5 | 0.711288 | 3 | 0 | 3 |
| MMP21 | HRC | 0.711022 | 4 | 0 | 3 |
| MMP21 | ZNF667 | 0.703579 | 3 | 0 | 3 |
| MMP21 | BTNL2 | 0.703517 | 3 | 0 | 3 |
| MMP21 | C20orf173 | 0.703137 | 3 | 0 | 3 |
| MMP21 | NXNL1 | 0.699433 | 3 | 0 | 3 |
| MMP21 | OR2B11 | 0.698183 | 3 | 0 | 3 |
| MMP21 | LYZL2 | 0.697462 | 3 | 0 | 3 |
| MMP21 | INSC | 0.696385 | 4 | 0 | 4 |
| MMP21 | OR4A15 | 0.689416 | 3 | 0 | 3 |
| MMP21 | FSCN3 | 0.688529 | 3 | 0 | 3 |
| MMP21 | POLL | 0.683911 | 3 | 0 | 3 |
For details and further investigation, click here
