| Full name: paired like homeodomain 3 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 10q24.32 | ||
| Entrez ID: 5309 | HGNC ID: HGNC:9006 | Ensembl Gene: ENSG00000107859 | OMIM ID: 602669 |
| Drug and gene relationship at DGIdb | |||
Expression of PITX3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PITX3 | 5309 | 208277_at | -0.1645 | 0.4027 | |
| GSE20347 | PITX3 | 5309 | 208277_at | -0.2375 | 0.0026 | |
| GSE23400 | PITX3 | 5309 | 208277_at | -0.2029 | 0.0000 | |
| GSE26886 | PITX3 | 5309 | 208277_at | 0.1730 | 0.1458 | |
| GSE29001 | PITX3 | 5309 | 208277_at | -0.3627 | 0.0071 | |
| GSE38129 | PITX3 | 5309 | 208277_at | -0.2657 | 0.0006 | |
| GSE45670 | PITX3 | 5309 | 208277_at | -0.0463 | 0.6832 | |
| GSE53622 | PITX3 | 5309 | 76579 | 0.0010 | 0.9896 | |
| GSE53624 | PITX3 | 5309 | 76579 | 0.0983 | 0.1971 | |
| GSE63941 | PITX3 | 5309 | 208277_at | 0.0312 | 0.8688 | |
| GSE77861 | PITX3 | 5309 | 208277_at | -0.2426 | 0.0487 | |
| GSE97050 | PITX3 | 5309 | A_33_P3240318 | 0.0666 | 0.8270 | |
| TCGA | PITX3 | 5309 | RNAseq | 2.5450 | 0.0007 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by PITX3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PITX3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PITX3 | 5309 | 2 | 9 | 19 | |
| GSE20123 | PITX3 | 5309 | 2 | 8 | 20 | |
| GSE43470 | PITX3 | 5309 | 0 | 8 | 35 | |
| GSE46452 | PITX3 | 5309 | 0 | 11 | 48 | |
| GSE47630 | PITX3 | 5309 | 2 | 14 | 24 | |
| GSE54993 | PITX3 | 5309 | 8 | 0 | 62 | |
| GSE54994 | PITX3 | 5309 | 1 | 12 | 40 | |
| GSE60625 | PITX3 | 5309 | 0 | 0 | 11 | |
| GSE74703 | PITX3 | 5309 | 0 | 5 | 31 | |
| GSE74704 | PITX3 | 5309 | 1 | 4 | 15 | |
| TCGA | PITX3 | 5309 | 5 | 29 | 62 |
Total number of gains: 21; Total number of losses: 100; Total Number of normals: 367.
Somatic mutations of PITX3:
Generating mutation plots.
Highly correlated genes for PITX3:
Showing top 20/981 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PITX3 | TSSK2 | 0.703523 | 6 | 0 | 6 |
| PITX3 | DUSP13 | 0.70093 | 6 | 0 | 5 |
| PITX3 | GSTM5 | 0.689209 | 3 | 0 | 3 |
| PITX3 | PDE2A | 0.679905 | 3 | 0 | 3 |
| PITX3 | C15orf39 | 0.679084 | 3 | 0 | 3 |
| PITX3 | MMP25 | 0.67594 | 6 | 0 | 6 |
| PITX3 | DUX1 | 0.673373 | 7 | 0 | 6 |
| PITX3 | TMEM59L | 0.665656 | 8 | 0 | 8 |
| PITX3 | ARSF | 0.664899 | 5 | 0 | 5 |
| PITX3 | F11 | 0.663329 | 6 | 0 | 5 |
| PITX3 | HAAO | 0.663185 | 8 | 0 | 7 |
| PITX3 | GPR37L1 | 0.662677 | 6 | 0 | 6 |
| PITX3 | RABEP2 | 0.658554 | 4 | 0 | 3 |
| PITX3 | PLCD1 | 0.65776 | 5 | 0 | 5 |
| PITX3 | CEACAM3 | 0.65535 | 6 | 0 | 5 |
| PITX3 | OPRD1 | 0.652023 | 7 | 0 | 6 |
| PITX3 | NOXO1 | 0.650538 | 3 | 0 | 3 |
| PITX3 | LDOC1 | 0.649911 | 3 | 0 | 3 |
| PITX3 | EGLN2 | 0.649396 | 3 | 0 | 3 |
| PITX3 | PGM5 | 0.648894 | 5 | 0 | 5 |
For details and further investigation, click here
