| Full name: fibroblast growth factor 21 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 19q13.33 | ||
| Entrez ID: 26291 | HGNC ID: HGNC:3678 | Ensembl Gene: ENSG00000105550 | OMIM ID: 609436 |
| Drug and gene relationship at DGIdb | |||
FGF21 involved pathways:
Expression of FGF21:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FGF21 | 26291 | 221433_at | 0.0010 | 0.9973 | |
| GSE20347 | FGF21 | 26291 | 221433_at | -0.1180 | 0.0318 | |
| GSE23400 | FGF21 | 26291 | 221433_at | -0.2086 | 0.0000 | |
| GSE26886 | FGF21 | 26291 | 221433_at | 0.1184 | 0.2391 | |
| GSE29001 | FGF21 | 26291 | 221433_at | -0.3532 | 0.0075 | |
| GSE38129 | FGF21 | 26291 | 221433_at | -0.1830 | 0.0144 | |
| GSE45670 | FGF21 | 26291 | 221433_at | -0.0738 | 0.3948 | |
| GSE53622 | FGF21 | 26291 | 17070 | -0.2055 | 0.1296 | |
| GSE53624 | FGF21 | 26291 | 17070 | -0.1087 | 0.2553 | |
| GSE63941 | FGF21 | 26291 | 221433_at | 0.8221 | 0.4331 | |
| GSE77861 | FGF21 | 26291 | 221433_at | -0.1250 | 0.0956 | |
| GSE97050 | FGF21 | 26291 | A_23_P101564 | -0.2562 | 0.6242 | |
| TCGA | FGF21 | 26291 | RNAseq | 2.0410 | 0.1468 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by FGF21 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of FGF21:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FGF21 | 26291 | 4 | 4 | 22 | |
| GSE20123 | FGF21 | 26291 | 4 | 3 | 23 | |
| GSE43470 | FGF21 | 26291 | 4 | 10 | 29 | |
| GSE46452 | FGF21 | 26291 | 45 | 1 | 13 | |
| GSE47630 | FGF21 | 26291 | 9 | 6 | 25 | |
| GSE54993 | FGF21 | 26291 | 17 | 4 | 49 | |
| GSE54994 | FGF21 | 26291 | 4 | 14 | 35 | |
| GSE60625 | FGF21 | 26291 | 9 | 0 | 2 | |
| GSE74703 | FGF21 | 26291 | 4 | 7 | 25 | |
| GSE74704 | FGF21 | 26291 | 4 | 1 | 15 | |
| TCGA | FGF21 | 26291 | 14 | 18 | 64 |
Total number of gains: 118; Total number of losses: 68; Total Number of normals: 302.
Somatic mutations of FGF21:
Generating mutation plots.
Highly correlated genes for FGF21:
Showing top 20/1022 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FGF21 | PGM5 | 0.727962 | 3 | 0 | 3 |
| FGF21 | CELF4 | 0.706726 | 3 | 0 | 3 |
| FGF21 | MAP3K10 | 0.69137 | 6 | 0 | 6 |
| FGF21 | MAP1LC3B2 | 0.689351 | 3 | 0 | 3 |
| FGF21 | NXNL1 | 0.688529 | 4 | 0 | 3 |
| FGF21 | TSSK2 | 0.688443 | 5 | 0 | 4 |
| FGF21 | SSTR4 | 0.688426 | 7 | 0 | 6 |
| FGF21 | CABP4 | 0.681351 | 3 | 0 | 3 |
| FGF21 | IBA57 | 0.679648 | 5 | 0 | 4 |
| FGF21 | TONSL | 0.678984 | 4 | 0 | 4 |
| FGF21 | RTBDN | 0.676899 | 4 | 0 | 4 |
| FGF21 | NTRK3 | 0.676751 | 4 | 0 | 4 |
| FGF21 | HSF4 | 0.67623 | 3 | 0 | 3 |
| FGF21 | TCP10L | 0.674634 | 5 | 0 | 4 |
| FGF21 | ARHGAP30 | 0.671564 | 3 | 0 | 3 |
| FGF21 | PLA2G6 | 0.67074 | 3 | 0 | 3 |
| FGF21 | IQSEC2 | 0.670575 | 6 | 0 | 6 |
| FGF21 | CYP2D6 | 0.670516 | 5 | 0 | 5 |
| FGF21 | CYP2A6 | 0.669447 | 8 | 0 | 7 |
| FGF21 | MC5R | 0.669353 | 7 | 0 | 7 |
For details and further investigation, click here
