| Full name: membrane palmitoylated protein 5 | Alias Symbol: PALS1|FLJ12615 | ||
| Type: protein-coding gene | Cytoband: 14q23.3 | ||
| Entrez ID: 64398 | HGNC ID: HGNC:18669 | Ensembl Gene: ENSG00000072415 | OMIM ID: 606958 |
| Drug and gene relationship at DGIdb | |||
MPP5 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04530 | Tight junction |
Expression of MPP5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MPP5 | 64398 | 226092_at | -0.2355 | 0.7341 | |
| GSE20347 | MPP5 | 64398 | 219321_at | -0.9266 | 0.0000 | |
| GSE23400 | MPP5 | 64398 | 219321_at | -0.3917 | 0.0000 | |
| GSE26886 | MPP5 | 64398 | 226092_at | -1.5687 | 0.0000 | |
| GSE29001 | MPP5 | 64398 | 219321_at | -0.9164 | 0.0516 | |
| GSE38129 | MPP5 | 64398 | 219321_at | -0.6190 | 0.0006 | |
| GSE45670 | MPP5 | 64398 | 226092_at | -0.3450 | 0.0101 | |
| GSE53622 | MPP5 | 64398 | 48716 | -0.7745 | 0.0000 | |
| GSE53624 | MPP5 | 64398 | 48716 | -0.9640 | 0.0000 | |
| GSE63941 | MPP5 | 64398 | 226092_at | -0.2667 | 0.4784 | |
| GSE77861 | MPP5 | 64398 | 226092_at | -1.1181 | 0.0029 | |
| GSE97050 | MPP5 | 64398 | A_33_P3248967 | -0.4567 | 0.1133 | |
| SRP007169 | MPP5 | 64398 | RNAseq | -1.6393 | 0.0000 | |
| SRP008496 | MPP5 | 64398 | RNAseq | -1.7930 | 0.0000 | |
| SRP064894 | MPP5 | 64398 | RNAseq | -1.1384 | 0.0000 | |
| SRP133303 | MPP5 | 64398 | RNAseq | -0.4725 | 0.0087 | |
| SRP159526 | MPP5 | 64398 | RNAseq | -1.2942 | 0.0000 | |
| SRP193095 | MPP5 | 64398 | RNAseq | -0.9165 | 0.0000 | |
| SRP219564 | MPP5 | 64398 | RNAseq | -0.9718 | 0.0259 | |
| TCGA | MPP5 | 64398 | RNAseq | -0.1677 | 0.0013 |
Upregulated datasets: 0; Downregulated datasets: 6.
Survival by MPP5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MPP5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MPP5 | 64398 | 7 | 3 | 20 | |
| GSE20123 | MPP5 | 64398 | 7 | 3 | 20 | |
| GSE43470 | MPP5 | 64398 | 8 | 2 | 33 | |
| GSE46452 | MPP5 | 64398 | 16 | 3 | 40 | |
| GSE47630 | MPP5 | 64398 | 11 | 9 | 20 | |
| GSE54993 | MPP5 | 64398 | 3 | 9 | 58 | |
| GSE54994 | MPP5 | 64398 | 18 | 5 | 30 | |
| GSE60625 | MPP5 | 64398 | 0 | 2 | 9 | |
| GSE74703 | MPP5 | 64398 | 7 | 2 | 27 | |
| GSE74704 | MPP5 | 64398 | 3 | 2 | 15 | |
| TCGA | MPP5 | 64398 | 34 | 14 | 48 |
Total number of gains: 114; Total number of losses: 54; Total Number of normals: 320.
Somatic mutations of MPP5:
Generating mutation plots.
Highly correlated genes for MPP5:
Showing top 20/1757 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MPP5 | ACTR2 | 0.843093 | 3 | 0 | 3 |
| MPP5 | CNOT4 | 0.813881 | 3 | 0 | 3 |
| MPP5 | ZNF70 | 0.785626 | 3 | 0 | 3 |
| MPP5 | ZNF416 | 0.778266 | 4 | 0 | 4 |
| MPP5 | ZCCHC9 | 0.778083 | 4 | 0 | 4 |
| MPP5 | GSKIP | 0.764936 | 6 | 0 | 6 |
| MPP5 | BRK1 | 0.760319 | 6 | 0 | 6 |
| MPP5 | CCDC7 | 0.75794 | 3 | 0 | 3 |
| MPP5 | GOLGA4 | 0.75744 | 8 | 0 | 7 |
| MPP5 | CRBN | 0.755731 | 5 | 0 | 5 |
| MPP5 | GGA3 | 0.748295 | 4 | 0 | 3 |
| MPP5 | ZKSCAN1 | 0.747627 | 3 | 0 | 3 |
| MPP5 | CCDC6 | 0.746931 | 11 | 0 | 10 |
| MPP5 | TMEM117 | 0.742795 | 3 | 0 | 3 |
| MPP5 | ARHGAP5-AS1 | 0.741921 | 6 | 0 | 6 |
| MPP5 | RNF141 | 0.741627 | 11 | 0 | 11 |
| MPP5 | KCTD10 | 0.740913 | 3 | 0 | 3 |
| MPP5 | RNF11 | 0.738462 | 11 | 0 | 11 |
| MPP5 | ZFC3H1 | 0.738348 | 3 | 0 | 3 |
| MPP5 | FCHO2 | 0.738187 | 7 | 0 | 7 |
For details and further investigation, click here
