| Full name: myelin protein zero | Alias Symbol: HMSNIB|CMT2I|CMT2J | ||
| Type: protein-coding gene | Cytoband: 1q23.3 | ||
| Entrez ID: 4359 | HGNC ID: HGNC:7225 | Ensembl Gene: ENSG00000158887 | OMIM ID: 159440 |
| Drug and gene relationship at DGIdb | |||
Expression of MPZ:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MPZ | 4359 | 210280_at | -0.1428 | 0.6044 | |
| GSE20347 | MPZ | 4359 | 210280_at | 0.1781 | 0.2724 | |
| GSE23400 | MPZ | 4359 | 210280_at | -0.1902 | 0.0001 | |
| GSE26886 | MPZ | 4359 | 210280_at | 0.0916 | 0.4264 | |
| GSE29001 | MPZ | 4359 | 210280_at | -0.0353 | 0.8385 | |
| GSE38129 | MPZ | 4359 | 210280_at | -0.7309 | 0.0181 | |
| GSE45670 | MPZ | 4359 | 210280_at | -0.3170 | 0.0015 | |
| GSE53622 | MPZ | 4359 | 39555 | -0.5116 | 0.0015 | |
| GSE53624 | MPZ | 4359 | 6088 | -2.1298 | 0.0000 | |
| GSE63941 | MPZ | 4359 | 210280_at | -0.2627 | 0.0500 | |
| GSE77861 | MPZ | 4359 | 210280_at | 0.0097 | 0.9433 | |
| GSE97050 | MPZ | 4359 | A_23_P138089 | -0.6305 | 0.1873 | |
| SRP064894 | MPZ | 4359 | RNAseq | -1.4191 | 0.0000 | |
| SRP133303 | MPZ | 4359 | RNAseq | -1.5683 | 0.0004 | |
| SRP219564 | MPZ | 4359 | RNAseq | -0.9097 | 0.2854 | |
| TCGA | MPZ | 4359 | RNAseq | -1.0659 | 0.0001 |
Upregulated datasets: 0; Downregulated datasets: 4.
Survival by MPZ expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MPZ:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MPZ | 4359 | 11 | 0 | 19 | |
| GSE20123 | MPZ | 4359 | 11 | 0 | 19 | |
| GSE43470 | MPZ | 4359 | 7 | 2 | 34 | |
| GSE46452 | MPZ | 4359 | 2 | 1 | 56 | |
| GSE47630 | MPZ | 4359 | 14 | 0 | 26 | |
| GSE54993 | MPZ | 4359 | 0 | 5 | 65 | |
| GSE54994 | MPZ | 4359 | 16 | 0 | 37 | |
| GSE60625 | MPZ | 4359 | 0 | 0 | 11 | |
| GSE74703 | MPZ | 4359 | 7 | 2 | 27 | |
| GSE74704 | MPZ | 4359 | 5 | 0 | 15 | |
| TCGA | MPZ | 4359 | 44 | 3 | 49 |
Total number of gains: 117; Total number of losses: 13; Total Number of normals: 358.
Somatic mutations of MPZ:
Generating mutation plots.
Highly correlated genes for MPZ:
Showing top 20/483 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MPZ | GRM7 | 0.71184 | 3 | 0 | 3 |
| MPZ | OR12D2 | 0.711739 | 3 | 0 | 3 |
| MPZ | GKAP1 | 0.706867 | 3 | 0 | 3 |
| MPZ | CDRT15 | 0.69857 | 3 | 0 | 3 |
| MPZ | RERGL | 0.693881 | 3 | 0 | 3 |
| MPZ | ECM2 | 0.679139 | 3 | 0 | 3 |
| MPZ | FBXO24 | 0.67426 | 3 | 0 | 3 |
| MPZ | RTBDN | 0.674135 | 3 | 0 | 3 |
| MPZ | MEF2C-AS1 | 0.6698 | 3 | 0 | 3 |
| MPZ | GRIK5 | 0.667566 | 6 | 0 | 5 |
| MPZ | OR10H3 | 0.666299 | 4 | 0 | 3 |
| MPZ | GPR17 | 0.666022 | 3 | 0 | 3 |
| MPZ | HOXB1 | 0.660564 | 4 | 0 | 4 |
| MPZ | GCM2 | 0.658299 | 3 | 0 | 3 |
| MPZ | DRD2 | 0.658151 | 5 | 0 | 5 |
| MPZ | KCNG4 | 0.655293 | 3 | 0 | 3 |
| MPZ | ACRV1 | 0.652769 | 4 | 0 | 4 |
| MPZ | PHEX | 0.650066 | 4 | 0 | 4 |
| MPZ | CD1B | 0.649696 | 4 | 0 | 3 |
| MPZ | MYBPC3 | 0.646719 | 4 | 0 | 4 |
For details and further investigation, click here
