| Full name: mitochondrial ribosomal protein L34 | Alias Symbol: L34mt|MGC2633|MGC24974 | ||
| Type: protein-coding gene | Cytoband: 19p13.1 | ||
| Entrez ID: 64981 | HGNC ID: HGNC:14488 | Ensembl Gene: ENSG00000130312 | OMIM ID: 611840 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of MRPL34:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MRPL34 | 64981 | 221692_s_at | 0.0406 | 0.9518 | |
| GSE20347 | MRPL34 | 64981 | 221692_s_at | 0.1363 | 0.3199 | |
| GSE23400 | MRPL34 | 64981 | 221692_s_at | 0.2400 | 0.0109 | |
| GSE26886 | MRPL34 | 64981 | 221692_s_at | 0.3397 | 0.2607 | |
| GSE29001 | MRPL34 | 64981 | 221692_s_at | 0.2766 | 0.3579 | |
| GSE38129 | MRPL34 | 64981 | 221692_s_at | 0.0820 | 0.5891 | |
| GSE45670 | MRPL34 | 64981 | 221692_s_at | 0.1001 | 0.6555 | |
| GSE53622 | MRPL34 | 64981 | 593 | -0.0230 | 0.7590 | |
| GSE53624 | MRPL34 | 64981 | 593 | 0.1299 | 0.0377 | |
| GSE63941 | MRPL34 | 64981 | 221692_s_at | 0.6207 | 0.0456 | |
| GSE77861 | MRPL34 | 64981 | 221692_s_at | 0.2737 | 0.3860 | |
| GSE97050 | MRPL34 | 64981 | A_24_P125690 | -0.2303 | 0.4389 | |
| SRP007169 | MRPL34 | 64981 | RNAseq | -0.4736 | 0.2643 | |
| SRP008496 | MRPL34 | 64981 | RNAseq | -0.3642 | 0.1067 | |
| SRP064894 | MRPL34 | 64981 | RNAseq | 0.2118 | 0.4708 | |
| SRP133303 | MRPL34 | 64981 | RNAseq | -0.0653 | 0.6953 | |
| SRP159526 | MRPL34 | 64981 | RNAseq | 0.1361 | 0.4532 | |
| SRP193095 | MRPL34 | 64981 | RNAseq | -0.4029 | 0.0022 | |
| SRP219564 | MRPL34 | 64981 | RNAseq | 0.1906 | 0.6885 | |
| TCGA | MRPL34 | 64981 | RNAseq | -0.1347 | 0.0275 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by MRPL34 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MRPL34:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MRPL34 | 64981 | 4 | 4 | 22 | |
| GSE20123 | MRPL34 | 64981 | 3 | 2 | 25 | |
| GSE43470 | MRPL34 | 64981 | 2 | 6 | 35 | |
| GSE46452 | MRPL34 | 64981 | 47 | 1 | 11 | |
| GSE47630 | MRPL34 | 64981 | 4 | 8 | 28 | |
| GSE54993 | MRPL34 | 64981 | 15 | 4 | 51 | |
| GSE54994 | MRPL34 | 64981 | 6 | 14 | 33 | |
| GSE60625 | MRPL34 | 64981 | 9 | 0 | 2 | |
| GSE74703 | MRPL34 | 64981 | 2 | 4 | 30 | |
| GSE74704 | MRPL34 | 64981 | 0 | 2 | 18 | |
| TCGA | MRPL34 | 64981 | 17 | 9 | 70 |
Total number of gains: 109; Total number of losses: 54; Total Number of normals: 325.
Somatic mutations of MRPL34:
Generating mutation plots.
Highly correlated genes for MRPL34:
Showing top 20/408 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MRPL34 | FAN1 | 0.784437 | 3 | 0 | 3 |
| MRPL34 | TSFM | 0.703331 | 3 | 0 | 3 |
| MRPL34 | TLN2 | 0.699438 | 3 | 0 | 3 |
| MRPL34 | RSBN1 | 0.692042 | 3 | 0 | 3 |
| MRPL34 | DHRSX | 0.68802 | 3 | 0 | 3 |
| MRPL34 | ZNF251 | 0.687626 | 3 | 0 | 3 |
| MRPL34 | FOXJ2 | 0.673714 | 4 | 0 | 3 |
| MRPL34 | LRP6 | 0.67308 | 4 | 0 | 4 |
| MRPL34 | COX6C | 0.656427 | 7 | 0 | 5 |
| MRPL34 | CDC26 | 0.651927 | 4 | 0 | 3 |
| MRPL34 | MKRN1 | 0.634875 | 3 | 0 | 3 |
| MRPL34 | UNC45A | 0.633463 | 4 | 0 | 3 |
| MRPL34 | FEM1B | 0.633119 | 3 | 0 | 3 |
| MRPL34 | SORL1 | 0.632176 | 5 | 0 | 4 |
| MRPL34 | C15orf61 | 0.631835 | 5 | 0 | 4 |
| MRPL34 | ZNF747 | 0.630868 | 4 | 0 | 3 |
| MRPL34 | NDUFA8 | 0.630477 | 5 | 0 | 4 |
| MRPL34 | C12orf57 | 0.627957 | 6 | 0 | 4 |
| MRPL34 | NOM1 | 0.627201 | 3 | 0 | 3 |
| MRPL34 | PPP2R2D | 0.626797 | 6 | 0 | 4 |
For details and further investigation, click here
