| Full name: cytochrome c oxidase subunit 6C | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 8q22.2 | ||
| Entrez ID: 1345 | HGNC ID: HGNC:2285 | Ensembl Gene: ENSG00000164919 | OMIM ID: 124090 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of COX6C:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | COX6C | 1345 | 201754_at | 0.3733 | 0.1731 | |
| GSE20347 | COX6C | 1345 | 201754_at | 0.4464 | 0.0017 | |
| GSE23400 | COX6C | 1345 | 201754_at | 0.3139 | 0.0000 | |
| GSE26886 | COX6C | 1345 | 201754_at | 0.0836 | 0.6853 | |
| GSE29001 | COX6C | 1345 | 201754_at | 0.2807 | 0.2309 | |
| GSE38129 | COX6C | 1345 | 201754_at | 0.2884 | 0.0053 | |
| GSE45670 | COX6C | 1345 | 201754_at | 0.2382 | 0.0373 | |
| GSE53622 | COX6C | 1345 | 18818 | -0.0189 | 0.7604 | |
| GSE53624 | COX6C | 1345 | 18818 | 0.3411 | 0.0000 | |
| GSE63941 | COX6C | 1345 | 201754_at | 0.3881 | 0.1613 | |
| GSE77861 | COX6C | 1345 | 201754_at | 0.2691 | 0.1280 | |
| GSE97050 | COX6C | 1345 | A_23_P8900 | -0.3205 | 0.3320 | |
| SRP007169 | COX6C | 1345 | RNAseq | -0.6196 | 0.0588 | |
| SRP008496 | COX6C | 1345 | RNAseq | -0.5094 | 0.0142 | |
| SRP064894 | COX6C | 1345 | RNAseq | 0.4650 | 0.1567 | |
| SRP133303 | COX6C | 1345 | RNAseq | 0.2023 | 0.2824 | |
| SRP159526 | COX6C | 1345 | RNAseq | 0.2604 | 0.4392 | |
| SRP193095 | COX6C | 1345 | RNAseq | -0.4219 | 0.0167 | |
| SRP219564 | COX6C | 1345 | RNAseq | -0.0090 | 0.9849 | |
| TCGA | COX6C | 1345 | RNAseq | -0.0055 | 0.9138 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by COX6C expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of COX6C:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | COX6C | 1345 | 17 | 0 | 13 | |
| GSE20123 | COX6C | 1345 | 17 | 0 | 13 | |
| GSE43470 | COX6C | 1345 | 21 | 0 | 22 | |
| GSE46452 | COX6C | 1345 | 24 | 0 | 35 | |
| GSE47630 | COX6C | 1345 | 24 | 0 | 16 | |
| GSE54993 | COX6C | 1345 | 0 | 20 | 50 | |
| GSE54994 | COX6C | 1345 | 38 | 1 | 14 | |
| GSE60625 | COX6C | 1345 | 0 | 4 | 7 | |
| GSE74703 | COX6C | 1345 | 18 | 0 | 18 | |
| GSE74704 | COX6C | 1345 | 12 | 0 | 8 | |
| TCGA | COX6C | 1345 | 57 | 1 | 38 |
Total number of gains: 228; Total number of losses: 26; Total Number of normals: 234.
Somatic mutations of COX6C:
Generating mutation plots.
Highly correlated genes for COX6C:
Showing top 20/535 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| COX6C | MRPS6 | 0.750098 | 3 | 0 | 3 |
| COX6C | METTL8 | 0.742138 | 3 | 0 | 3 |
| COX6C | RBM17 | 0.729442 | 3 | 0 | 3 |
| COX6C | CCDC127 | 0.725378 | 3 | 0 | 3 |
| COX6C | POLR2K | 0.718817 | 10 | 0 | 10 |
| COX6C | FUCA2 | 0.715501 | 3 | 0 | 3 |
| COX6C | USP21 | 0.706497 | 4 | 0 | 4 |
| COX6C | PPIE | 0.706367 | 3 | 0 | 3 |
| COX6C | ZNF787 | 0.696784 | 3 | 0 | 3 |
| COX6C | ZNF518B | 0.695147 | 4 | 0 | 4 |
| COX6C | SAMD1 | 0.690233 | 3 | 0 | 3 |
| COX6C | GPATCH2 | 0.679197 | 3 | 0 | 3 |
| COX6C | PAIP2 | 0.677318 | 3 | 0 | 3 |
| COX6C | TP53RK | 0.673379 | 3 | 0 | 3 |
| COX6C | ERGIC2 | 0.669542 | 3 | 0 | 3 |
| COX6C | ADNP | 0.669109 | 3 | 0 | 3 |
| COX6C | HMGXB4 | 0.669043 | 4 | 0 | 4 |
| COX6C | CTSF | 0.668476 | 3 | 0 | 3 |
| COX6C | FAM32A | 0.665235 | 4 | 0 | 4 |
| COX6C | XXYLT1 | 0.663698 | 4 | 0 | 4 |
For details and further investigation, click here
