Full name: NADH:ubiquinone oxidoreductase subunit A8	Alias Symbol: PGIV|MGC793
Type: protein-coding gene	Cytoband: 9q33.2
Entrez ID: 4702	HGNC ID: HGNC:7692	Ensembl Gene: ENSG00000119421	OMIM ID: 603359
Drug and gene relationship at DGIdb
Screen Evidence: Knocking out of this gene by CRIPR/Cas9 screen found 79/325 cell lines had fitness change in Project Score. Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

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Expression of NDUFA8:

 

Dataset	Gene	EntrezID	Probe	Log2FC	Adj.pValue	Expression
GSE17351	NDUFA8	4702	218160_at	-0.1077	0.7130	Show
GSE20347	NDUFA8	4702	218160_at	0.0029	0.9913	Show
GSE23400	NDUFA8	4702	218160_at	0.1641	0.0517	Show
GSE26886	NDUFA8	4702	218160_at	-0.0695	0.7579	Show
GSE29001	NDUFA8	4702	218160_at	0.1646	0.6995	Show
GSE38129	NDUFA8	4702	218160_at	-0.0379	0.8236	Show
GSE45670	NDUFA8	4702	218160_at	0.1535	0.3155	Show
GSE63941	NDUFA8	4702	218160_at	1.0285	0.0219	Show
GSE77861	NDUFA8	4702	218160_at	0.1935	0.3862	Show
GSE97050	NDUFA8	4702	A_23_P43566	-0.2371	0.4145	Show
SRP007169	NDUFA8	4702	RNAseq	0.4058	0.3761	Show
SRP008496	NDUFA8	4702	RNAseq	0.3494	0.2521	Show
SRP064894	NDUFA8	4702	RNAseq	0.7336	0.0187	Show
SRP133303	NDUFA8	4702	RNAseq	0.4198	0.0035	Show
SRP159526	NDUFA8	4702	RNAseq	0.3252	0.1729	Show
SRP193095	NDUFA8	4702	RNAseq	-0.1586	0.2278	Show
SRP219564	NDUFA8	4702	RNAseq	-0.1450	0.7508	Show
TCGA	NDUFA8	4702	RNAseq	-0.1070	0.1102	Show

Upregulated datasets: 1; Downregulated datasets: 0.  Download Data

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Survival by NDUFA8 expression:

 

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Copy number change of NDUFA8:

 

Dataset	Gene	EntrezID	Gain	Loss	Normal	Detail
GSE15526	NDUFA8	4702	3	7	20	Show
GSE20123	NDUFA8	4702	3	7	20	Show
GSE43470	NDUFA8	4702	5	4	34	Show
GSE46452	NDUFA8	4702	6	13	40	Show
GSE47630	NDUFA8	4702	3	16	21	Show
GSE54993	NDUFA8	4702	3	3	64	Show
GSE54994	NDUFA8	4702	9	10	34	Show
GSE60625	NDUFA8	4702	0	0	11	Show
GSE74703	NDUFA8	4702	5	3	28	Show
GSE74704	NDUFA8	4702	2	5	13	Show
TCGA	NDUFA8	4702	27	24	45	Show

Total number of gains: 66; Total number of losses: 92; Total Number of normals: 330.  Download Data

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Somatic mutations of NDUFA8:

 

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Highly correlated genes for NDUFA8:

 

Showing top 20/288 corelated genes with mean PCC>0.5.

Gene1	Gene2	Mean PCC	Num. Datasets	Num. PCC<0	Num. PCC>0.5
NDUFA8	LSM11	0.813177	3	0	3
NDUFA8	SIK1	0.757252	3	0	3
NDUFA8	SRSF4	0.740307	3	0	3
NDUFA8	NUPR1	0.737688	3	0	3
NDUFA8	C12orf57	0.728307	3	0	3
NDUFA8	UNC45A	0.724594	3	0	3
NDUFA8	LBR	0.724078	3	0	3
NDUFA8	PLSCR4	0.721565	3	0	3
NDUFA8	PIGA	0.71915	3	0	3
NDUFA8	AGBL5	0.718201	3	0	3
NDUFA8	BABAM1	0.717362	3	0	3
NDUFA8	NFKB1	0.716375	3	0	3
NDUFA8	DET1	0.705646	3	0	3
NDUFA8	ACRBP	0.704584	3	0	3
NDUFA8	MAOB	0.702986	3	0	3
NDUFA8	AZIN1	0.698311	3	0	3
NDUFA8	STUB1	0.695748	3	0	3
NDUFA8	EID1	0.695361	4	0	3
NDUFA8	COPZ1	0.691205	3	0	3
NDUFA8	ARIH2	0.689046	3	0	3

For details and further investigation, click here