| Full name: makorin ring finger protein 1 | Alias Symbol: RNF61 | ||
| Type: protein-coding gene | Cytoband: 7q34 | ||
| Entrez ID: 23608 | HGNC ID: HGNC:7112 | Ensembl Gene: ENSG00000133606 | OMIM ID: 607754 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of MKRN1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MKRN1 | 23608 | 201285_at | -0.1790 | 0.8103 | |
| GSE20347 | MKRN1 | 23608 | 201285_at | 0.0294 | 0.8440 | |
| GSE23400 | MKRN1 | 23608 | 201285_at | 0.1146 | 0.0887 | |
| GSE26886 | MKRN1 | 23608 | 201285_at | -1.3043 | 0.0001 | |
| GSE29001 | MKRN1 | 23608 | 201285_at | 0.1226 | 0.5979 | |
| GSE38129 | MKRN1 | 23608 | 201285_at | -0.0420 | 0.6813 | |
| GSE45670 | MKRN1 | 23608 | 201285_at | 0.0302 | 0.8892 | |
| GSE53622 | MKRN1 | 23608 | 79072 | -0.0911 | 0.2149 | |
| GSE53624 | MKRN1 | 23608 | 79072 | 0.0788 | 0.0846 | |
| GSE63941 | MKRN1 | 23608 | 201285_at | 0.2308 | 0.5510 | |
| GSE77861 | MKRN1 | 23608 | 201285_at | 0.3447 | 0.0979 | |
| GSE97050 | MKRN1 | 23608 | A_23_P59798 | -0.2754 | 0.3813 | |
| SRP007169 | MKRN1 | 23608 | RNAseq | -0.6291 | 0.0935 | |
| SRP008496 | MKRN1 | 23608 | RNAseq | -0.5825 | 0.0117 | |
| SRP064894 | MKRN1 | 23608 | RNAseq | -0.2190 | 0.0606 | |
| SRP133303 | MKRN1 | 23608 | RNAseq | 0.0539 | 0.6704 | |
| SRP159526 | MKRN1 | 23608 | RNAseq | -0.0753 | 0.7538 | |
| SRP193095 | MKRN1 | 23608 | RNAseq | -0.2820 | 0.0065 | |
| SRP219564 | MKRN1 | 23608 | RNAseq | -0.6275 | 0.0015 | |
| TCGA | MKRN1 | 23608 | RNAseq | -0.0574 | 0.2015 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by MKRN1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MKRN1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MKRN1 | 23608 | 5 | 2 | 23 | |
| GSE20123 | MKRN1 | 23608 | 5 | 2 | 23 | |
| GSE43470 | MKRN1 | 23608 | 2 | 4 | 37 | |
| GSE46452 | MKRN1 | 23608 | 7 | 2 | 50 | |
| GSE47630 | MKRN1 | 23608 | 7 | 4 | 29 | |
| GSE54993 | MKRN1 | 23608 | 3 | 5 | 62 | |
| GSE54994 | MKRN1 | 23608 | 5 | 8 | 40 | |
| GSE60625 | MKRN1 | 23608 | 0 | 0 | 11 | |
| GSE74703 | MKRN1 | 23608 | 2 | 4 | 30 | |
| GSE74704 | MKRN1 | 23608 | 1 | 2 | 17 | |
| TCGA | MKRN1 | 23608 | 28 | 23 | 45 |
Total number of gains: 65; Total number of losses: 56; Total Number of normals: 367.
Somatic mutations of MKRN1:
Generating mutation plots.
Highly correlated genes for MKRN1:
Showing top 20/277 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MKRN1 | UBE4B | 0.845146 | 3 | 0 | 3 |
| MKRN1 | TMEM219 | 0.826073 | 3 | 0 | 3 |
| MKRN1 | WDR77 | 0.820278 | 3 | 0 | 3 |
| MKRN1 | TRAPPC2 | 0.806273 | 3 | 0 | 3 |
| MKRN1 | TPRG1L | 0.803642 | 3 | 0 | 3 |
| MKRN1 | MRPS14 | 0.798321 | 3 | 0 | 3 |
| MKRN1 | STK40 | 0.79497 | 3 | 0 | 3 |
| MKRN1 | SRRM1 | 0.793092 | 3 | 0 | 3 |
| MKRN1 | COMMD2 | 0.792886 | 3 | 0 | 3 |
| MKRN1 | PUS7L | 0.785971 | 3 | 0 | 3 |
| MKRN1 | NCOA4 | 0.77027 | 3 | 0 | 3 |
| MKRN1 | MRPL38 | 0.769996 | 3 | 0 | 3 |
| MKRN1 | ZBED5 | 0.768965 | 3 | 0 | 3 |
| MKRN1 | FOXJ2 | 0.763683 | 3 | 0 | 3 |
| MKRN1 | SLC25A3 | 0.762164 | 4 | 0 | 3 |
| MKRN1 | NDUFS3 | 0.759058 | 3 | 0 | 3 |
| MKRN1 | ZFPL1 | 0.758642 | 3 | 0 | 3 |
| MKRN1 | ALG10 | 0.756684 | 3 | 0 | 3 |
| MKRN1 | SMARCE1 | 0.752844 | 3 | 0 | 3 |
| MKRN1 | IFNAR1 | 0.749444 | 3 | 0 | 3 |
For details and further investigation, click here
