| Full name: mitochondrial ribosomal protein L40 | Alias Symbol: MRP-L22 | ||
| Type: protein-coding gene | Cytoband: 22q11.21 | ||
| Entrez ID: 64976 | HGNC ID: HGNC:14491 | Ensembl Gene: ENSG00000185608 | OMIM ID: 605089 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of MRPL40:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MRPL40 | 64976 | 203152_at | -0.2773 | 0.2874 | |
| GSE20347 | MRPL40 | 64976 | 203152_at | 0.0846 | 0.7084 | |
| GSE23400 | MRPL40 | 64976 | 203152_at | 0.3125 | 0.0001 | |
| GSE26886 | MRPL40 | 64976 | 203152_at | 0.9725 | 0.0000 | |
| GSE29001 | MRPL40 | 64976 | 203152_at | 0.0824 | 0.8754 | |
| GSE38129 | MRPL40 | 64976 | 203152_at | 0.1987 | 0.2026 | |
| GSE45670 | MRPL40 | 64976 | 203152_at | 0.1358 | 0.3831 | |
| GSE53622 | MRPL40 | 64976 | 31057 | 0.3819 | 0.0000 | |
| GSE53624 | MRPL40 | 64976 | 31057 | 0.1649 | 0.0225 | |
| GSE63941 | MRPL40 | 64976 | 203152_at | 0.0457 | 0.9510 | |
| GSE77861 | MRPL40 | 64976 | 203152_at | 0.0898 | 0.6579 | |
| GSE97050 | MRPL40 | 64976 | A_24_P228667 | 0.2011 | 0.4188 | |
| SRP007169 | MRPL40 | 64976 | RNAseq | -0.0193 | 0.9515 | |
| SRP008496 | MRPL40 | 64976 | RNAseq | -0.2555 | 0.2818 | |
| SRP064894 | MRPL40 | 64976 | RNAseq | 0.5482 | 0.0747 | |
| SRP133303 | MRPL40 | 64976 | RNAseq | 0.1211 | 0.3015 | |
| SRP159526 | MRPL40 | 64976 | RNAseq | 0.5326 | 0.0398 | |
| SRP193095 | MRPL40 | 64976 | RNAseq | -0.0258 | 0.8627 | |
| SRP219564 | MRPL40 | 64976 | RNAseq | 0.1987 | 0.4167 | |
| TCGA | MRPL40 | 64976 | RNAseq | 0.0791 | 0.1975 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by MRPL40 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MRPL40:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MRPL40 | 64976 | 4 | 7 | 19 | |
| GSE20123 | MRPL40 | 64976 | 4 | 7 | 19 | |
| GSE43470 | MRPL40 | 64976 | 4 | 6 | 33 | |
| GSE46452 | MRPL40 | 64976 | 33 | 1 | 25 | |
| GSE47630 | MRPL40 | 64976 | 8 | 5 | 27 | |
| GSE54993 | MRPL40 | 64976 | 3 | 7 | 60 | |
| GSE54994 | MRPL40 | 64976 | 12 | 7 | 34 | |
| GSE60625 | MRPL40 | 64976 | 5 | 0 | 6 | |
| GSE74703 | MRPL40 | 64976 | 4 | 4 | 28 | |
| GSE74704 | MRPL40 | 64976 | 2 | 4 | 14 | |
| TCGA | MRPL40 | 64976 | 27 | 17 | 52 |
Total number of gains: 106; Total number of losses: 65; Total Number of normals: 317.
Somatic mutations of MRPL40:
Generating mutation plots.
Highly correlated genes for MRPL40:
Showing top 20/346 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MRPL40 | HERPUD2 | 0.760114 | 3 | 0 | 3 |
| MRPL40 | FBXO36 | 0.760098 | 3 | 0 | 3 |
| MRPL40 | BDP1 | 0.756473 | 3 | 0 | 3 |
| MRPL40 | TTC37 | 0.732992 | 3 | 0 | 3 |
| MRPL40 | UHRF1BP1L | 0.732619 | 3 | 0 | 3 |
| MRPL40 | MRPL46 | 0.729736 | 4 | 0 | 4 |
| MRPL40 | SRPX | 0.729345 | 3 | 0 | 3 |
| MRPL40 | NEK9 | 0.718686 | 3 | 0 | 3 |
| MRPL40 | PIBF1 | 0.717417 | 3 | 0 | 3 |
| MRPL40 | RPS19BP1 | 0.717012 | 3 | 0 | 3 |
| MRPL40 | PRKAB2 | 0.705542 | 3 | 0 | 3 |
| MRPL40 | BAG4 | 0.693836 | 3 | 0 | 3 |
| MRPL40 | RNFT1 | 0.684258 | 3 | 0 | 3 |
| MRPL40 | EIF2B2 | 0.683375 | 4 | 0 | 3 |
| MRPL40 | RPL19 | 0.678873 | 6 | 0 | 6 |
| MRPL40 | UBE2N | 0.678722 | 3 | 0 | 3 |
| MRPL40 | ORC3 | 0.678484 | 4 | 0 | 4 |
| MRPL40 | CMC1 | 0.675022 | 4 | 0 | 3 |
| MRPL40 | SPIRE1 | 0.674812 | 4 | 0 | 3 |
| MRPL40 | SIN3A | 0.674212 | 3 | 0 | 3 |
For details and further investigation, click here
