| Full name: eukaryotic translation initiation factor 2B subunit beta | Alias Symbol: EIF2B|EIF-2Bbeta | ||
| Type: protein-coding gene | Cytoband: 14q24.3 | ||
| Entrez ID: 8892 | HGNC ID: HGNC:3258 | Ensembl Gene: ENSG00000119718 | OMIM ID: 606454 |
| Drug and gene relationship at DGIdb | |||
Expression of EIF2B2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | EIF2B2 | 8892 | 202461_at | -0.5148 | 0.3824 | |
| GSE20347 | EIF2B2 | 8892 | 202461_at | -0.1799 | 0.2462 | |
| GSE23400 | EIF2B2 | 8892 | 202461_at | 0.0997 | 0.1828 | |
| GSE26886 | EIF2B2 | 8892 | 202461_at | -0.0284 | 0.9108 | |
| GSE29001 | EIF2B2 | 8892 | 202461_at | -0.0327 | 0.8919 | |
| GSE38129 | EIF2B2 | 8892 | 202461_at | 0.0796 | 0.5456 | |
| GSE45670 | EIF2B2 | 8892 | 202461_at | 0.0326 | 0.8872 | |
| GSE53622 | EIF2B2 | 8892 | 41435 | 0.1699 | 0.0801 | |
| GSE53624 | EIF2B2 | 8892 | 41435 | 0.1916 | 0.0159 | |
| GSE63941 | EIF2B2 | 8892 | 202461_at | 0.7418 | 0.0959 | |
| GSE77861 | EIF2B2 | 8892 | 202461_at | -0.1194 | 0.7131 | |
| GSE97050 | EIF2B2 | 8892 | A_23_P25929 | 0.4357 | 0.1453 | |
| SRP007169 | EIF2B2 | 8892 | RNAseq | -0.5038 | 0.1749 | |
| SRP008496 | EIF2B2 | 8892 | RNAseq | -0.5408 | 0.0206 | |
| SRP064894 | EIF2B2 | 8892 | RNAseq | 0.2086 | 0.2147 | |
| SRP133303 | EIF2B2 | 8892 | RNAseq | -0.0881 | 0.4317 | |
| SRP159526 | EIF2B2 | 8892 | RNAseq | 0.1282 | 0.7218 | |
| SRP193095 | EIF2B2 | 8892 | RNAseq | 0.0111 | 0.9194 | |
| SRP219564 | EIF2B2 | 8892 | RNAseq | 0.0088 | 0.9873 | |
| TCGA | EIF2B2 | 8892 | RNAseq | 0.1411 | 0.0217 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by EIF2B2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of EIF2B2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | EIF2B2 | 8892 | 8 | 3 | 19 | |
| GSE20123 | EIF2B2 | 8892 | 8 | 3 | 19 | |
| GSE43470 | EIF2B2 | 8892 | 8 | 3 | 32 | |
| GSE46452 | EIF2B2 | 8892 | 16 | 3 | 40 | |
| GSE47630 | EIF2B2 | 8892 | 11 | 8 | 21 | |
| GSE54993 | EIF2B2 | 8892 | 3 | 8 | 59 | |
| GSE54994 | EIF2B2 | 8892 | 19 | 4 | 30 | |
| GSE60625 | EIF2B2 | 8892 | 0 | 2 | 9 | |
| GSE74703 | EIF2B2 | 8892 | 7 | 3 | 26 | |
| GSE74704 | EIF2B2 | 8892 | 3 | 3 | 14 | |
| TCGA | EIF2B2 | 8892 | 32 | 16 | 48 |
Total number of gains: 115; Total number of losses: 56; Total Number of normals: 317.
Somatic mutations of EIF2B2:
Generating mutation plots.
Highly correlated genes for EIF2B2:
Showing top 20/379 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| EIF2B2 | CUL2 | 0.754507 | 3 | 0 | 3 |
| EIF2B2 | SLC22A15 | 0.743416 | 3 | 0 | 3 |
| EIF2B2 | TMEM107 | 0.741904 | 3 | 0 | 3 |
| EIF2B2 | ESYT2 | 0.739749 | 3 | 0 | 3 |
| EIF2B2 | C1orf50 | 0.718377 | 5 | 0 | 5 |
| EIF2B2 | ANKRD9 | 0.710223 | 3 | 0 | 3 |
| EIF2B2 | SCOC | 0.707305 | 3 | 0 | 3 |
| EIF2B2 | COPS2 | 0.695278 | 6 | 0 | 6 |
| EIF2B2 | ALG13 | 0.69495 | 4 | 0 | 3 |
| EIF2B2 | COX10 | 0.684406 | 3 | 0 | 3 |
| EIF2B2 | MRPL40 | 0.683375 | 4 | 0 | 3 |
| EIF2B2 | GFM2 | 0.679306 | 4 | 0 | 3 |
| EIF2B2 | ATF1 | 0.677917 | 3 | 0 | 3 |
| EIF2B2 | ZRANB1 | 0.67698 | 3 | 0 | 3 |
| EIF2B2 | IDE | 0.675919 | 3 | 0 | 3 |
| EIF2B2 | CIB1 | 0.673932 | 3 | 0 | 3 |
| EIF2B2 | WNT5A | 0.673677 | 4 | 0 | 4 |
| EIF2B2 | IGBP1 | 0.664464 | 4 | 0 | 4 |
| EIF2B2 | PTGR1 | 0.664253 | 3 | 0 | 3 |
| EIF2B2 | FARSA | 0.664058 | 4 | 0 | 4 |
For details and further investigation, click here
