BAG4

 

Full name: BCL2 associated athanogene 4 Alias Symbol: SODD
Type: protein-coding gene Cytoband: 8p11.23
Entrez ID: 9530 HGNC ID: HGNC:940 Ensembl Gene: ENSG00000156735 OMIM ID: 603884
Drug and gene relationship at DGIdb

 

BAG4 involved pathways:

KEGG pathway Description View
hsa04668TNF signaling pathway

 

Expression of BAG4:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 BAG4 9530 228189_at 0.6705 0.1374
GSE20347 BAG4 9530 219624_at 0.5123 0.0531
GSE23400 BAG4 9530 219624_at 0.3538 0.0000
GSE26886 BAG4 9530 228189_at -0.2547 0.3710
GSE29001 BAG4 9530 219624_at 0.2154 0.7391
GSE38129 BAG4 9530 219624_at 0.6219 0.0034
GSE45670 BAG4 9530 228189_at 0.3711 0.0512
GSE53622 BAG4 9530 90515 0.7981 0.0000
GSE53624 BAG4 9530 10533 0.6735 0.0000
GSE63941 BAG4 9530 228189_at -0.6699 0.2542
GSE77861 BAG4 9530 228189_at 0.2204 0.4802
GSE97050 BAG4 9530 A_23_P146217 0.5366 0.2807
SRP007169 BAG4 9530 RNAseq 0.9489 0.0089
SRP008496 BAG4 9530 RNAseq 0.8371 0.0007
SRP064894 BAG4 9530 RNAseq 0.4304 0.0302
SRP133303 BAG4 9530 RNAseq 0.8258 0.0004
SRP159526 BAG4 9530 RNAseq 0.6503 0.0990
SRP193095 BAG4 9530 RNAseq 0.4702 0.0031
SRP219564 BAG4 9530 RNAseq 0.3160 0.3996
TCGA BAG4 9530 RNAseq 0.2861 0.0006

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by BAG4 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of BAG4:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 BAG4 9530 10 4 16
GSE20123 BAG4 9530 11 4 15
GSE43470 BAG4 9530 8 7 28
GSE46452 BAG4 9530 21 5 33
GSE47630 BAG4 9530 12 7 21
GSE54993 BAG4 9530 2 16 52
GSE54994 BAG4 9530 16 8 29
GSE60625 BAG4 9530 3 0 8
GSE74703 BAG4 9530 8 5 23
GSE74704 BAG4 9530 9 1 10
TCGA BAG4 9530 35 25 36

Total number of gains: 135; Total number of losses: 82; Total Number of normals: 271.  

 

Somatic mutations of BAG4:

 

Generating mutation plots.

 

Highly correlated genes for BAG4:

 

Showing top 20/650 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
BAG4ALG10.804651303
BAG4PXMP20.787177303
BAG4MCMBP0.779349303
BAG4HSPB110.776418303
BAG4MDM20.775261303
BAG4GIN10.764042303
BAG4EFTUD20.762131303
BAG4CSNK2A20.760997303
BAG4ATG4C0.757604303
BAG4LSM10.74126111010
BAG4MOB3C0.740709303
BAG4MBTPS20.740493403
BAG4CCP1100.738325303
BAG4NRM0.724138303
BAG4SLC37A30.712751303
BAG4LARS20.712239404
BAG4CBLL10.70795403
BAG4PIGU0.706553403
BAG4INTS90.706397403
BAG4SLC7A6OS0.706163404

For details and further investigation, click here