| Full name: ubiquitin conjugating enzyme E2 L3 | Alias Symbol: UBCH7 | ||
| Type: protein-coding gene | Cytoband: 22q11.21 | ||
| Entrez ID: 7332 | HGNC ID: HGNC:12488 | Ensembl Gene: ENSG00000185651 | OMIM ID: 603721 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of UBE2L3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | UBE2L3 | 7332 | 200682_s_at | 0.1106 | 0.7676 | |
| GSE20347 | UBE2L3 | 7332 | 200682_s_at | -0.3172 | 0.0675 | |
| GSE23400 | UBE2L3 | 7332 | 200682_s_at | 0.0704 | 0.3257 | |
| GSE26886 | UBE2L3 | 7332 | 200683_s_at | -0.4522 | 0.0057 | |
| GSE29001 | UBE2L3 | 7332 | 200682_s_at | -0.3000 | 0.5401 | |
| GSE38129 | UBE2L3 | 7332 | 200682_s_at | -0.0244 | 0.8984 | |
| GSE45670 | UBE2L3 | 7332 | 200682_s_at | 0.1256 | 0.5359 | |
| GSE53622 | UBE2L3 | 7332 | 47311 | -0.4733 | 0.0000 | |
| GSE53624 | UBE2L3 | 7332 | 76975 | -0.2265 | 0.0015 | |
| GSE63941 | UBE2L3 | 7332 | 200682_s_at | 0.6584 | 0.0921 | |
| GSE77861 | UBE2L3 | 7332 | 200682_s_at | 0.1271 | 0.6670 | |
| GSE97050 | UBE2L3 | 7332 | A_32_P91250 | 0.0413 | 0.8918 | |
| SRP007169 | UBE2L3 | 7332 | RNAseq | 0.0651 | 0.8345 | |
| SRP008496 | UBE2L3 | 7332 | RNAseq | 0.3544 | 0.2607 | |
| SRP064894 | UBE2L3 | 7332 | RNAseq | 0.2459 | 0.1935 | |
| SRP133303 | UBE2L3 | 7332 | RNAseq | 0.2070 | 0.1425 | |
| SRP159526 | UBE2L3 | 7332 | RNAseq | 0.0095 | 0.9626 | |
| SRP193095 | UBE2L3 | 7332 | RNAseq | -0.0022 | 0.9877 | |
| SRP219564 | UBE2L3 | 7332 | RNAseq | 0.3403 | 0.4404 | |
| TCGA | UBE2L3 | 7332 | RNAseq | 0.0493 | 0.2797 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by UBE2L3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of UBE2L3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | UBE2L3 | 7332 | 5 | 7 | 18 | |
| GSE20123 | UBE2L3 | 7332 | 5 | 7 | 18 | |
| GSE43470 | UBE2L3 | 7332 | 3 | 7 | 33 | |
| GSE46452 | UBE2L3 | 7332 | 33 | 1 | 25 | |
| GSE47630 | UBE2L3 | 7332 | 8 | 5 | 27 | |
| GSE54993 | UBE2L3 | 7332 | 3 | 6 | 61 | |
| GSE54994 | UBE2L3 | 7332 | 11 | 7 | 35 | |
| GSE60625 | UBE2L3 | 7332 | 5 | 0 | 6 | |
| GSE74703 | UBE2L3 | 7332 | 3 | 5 | 28 | |
| GSE74704 | UBE2L3 | 7332 | 2 | 4 | 14 | |
| TCGA | UBE2L3 | 7332 | 27 | 17 | 52 |
Total number of gains: 105; Total number of losses: 66; Total Number of normals: 317.
Somatic mutations of UBE2L3:
Generating mutation plots.
Highly correlated genes for UBE2L3:
Showing top 20/405 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| UBE2L3 | MFN1 | 0.805798 | 3 | 0 | 3 |
| UBE2L3 | PARG | 0.805678 | 3 | 0 | 3 |
| UBE2L3 | ATG3 | 0.789117 | 3 | 0 | 3 |
| UBE2L3 | C1orf122 | 0.785468 | 3 | 0 | 3 |
| UBE2L3 | RAB2A | 0.775911 | 3 | 0 | 3 |
| UBE2L3 | CLP1 | 0.765863 | 3 | 0 | 3 |
| UBE2L3 | RPUSD2 | 0.765209 | 3 | 0 | 3 |
| UBE2L3 | MFAP1 | 0.758771 | 3 | 0 | 3 |
| UBE2L3 | DNAJC21 | 0.756325 | 4 | 0 | 4 |
| UBE2L3 | HMGN1 | 0.751705 | 3 | 0 | 3 |
| UBE2L3 | MTO1 | 0.740498 | 4 | 0 | 4 |
| UBE2L3 | NECAP2 | 0.732052 | 3 | 0 | 3 |
| UBE2L3 | KANSL2 | 0.723627 | 3 | 0 | 3 |
| UBE2L3 | MTA3 | 0.720375 | 3 | 0 | 3 |
| UBE2L3 | WIPF2 | 0.715653 | 3 | 0 | 3 |
| UBE2L3 | WDR70 | 0.714516 | 3 | 0 | 3 |
| UBE2L3 | CETN2 | 0.707712 | 4 | 0 | 3 |
| UBE2L3 | LRP11 | 0.706188 | 3 | 0 | 3 |
| UBE2L3 | SUFU | 0.70479 | 3 | 0 | 3 |
| UBE2L3 | FAM122A | 0.698684 | 3 | 0 | 3 |
For details and further investigation, click here
