| Full name: 5-methyltetrahydrofolate-homocysteine methyltransferase | Alias Symbol: cblG | ||
| Type: protein-coding gene | Cytoband: 1q43 | ||
| Entrez ID: 4548 | HGNC ID: HGNC:7468 | Ensembl Gene: ENSG00000116984 | OMIM ID: 156570 |
| Drug and gene relationship at DGIdb | |||
Expression of MTR:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MTR | 4548 | 203774_at | 0.2223 | 0.6772 | |
| GSE20347 | MTR | 4548 | 203774_at | 0.7414 | 0.0001 | |
| GSE23400 | MTR | 4548 | 203774_at | 0.4671 | 0.0000 | |
| GSE26886 | MTR | 4548 | 203774_at | 1.9601 | 0.0000 | |
| GSE29001 | MTR | 4548 | 203774_at | 0.7759 | 0.0798 | |
| GSE38129 | MTR | 4548 | 203774_at | 0.5986 | 0.0001 | |
| GSE45670 | MTR | 4548 | 203774_at | -0.0055 | 0.9821 | |
| GSE53622 | MTR | 4548 | 70316 | 0.4829 | 0.0000 | |
| GSE53624 | MTR | 4548 | 70316 | 0.7464 | 0.0000 | |
| GSE63941 | MTR | 4548 | 203774_at | -1.2359 | 0.0018 | |
| GSE77861 | MTR | 4548 | 203774_at | 0.8470 | 0.0345 | |
| GSE97050 | MTR | 4548 | A_33_P3389917 | -0.4221 | 0.2622 | |
| SRP007169 | MTR | 4548 | RNAseq | 2.7404 | 0.0000 | |
| SRP008496 | MTR | 4548 | RNAseq | 2.5154 | 0.0000 | |
| SRP064894 | MTR | 4548 | RNAseq | 0.1912 | 0.4056 | |
| SRP133303 | MTR | 4548 | RNAseq | 0.3498 | 0.0477 | |
| SRP159526 | MTR | 4548 | RNAseq | 0.1898 | 0.3693 | |
| SRP193095 | MTR | 4548 | RNAseq | 0.4997 | 0.0000 | |
| SRP219564 | MTR | 4548 | RNAseq | 0.3612 | 0.2426 | |
| TCGA | MTR | 4548 | RNAseq | -0.1883 | 0.0012 |
Upregulated datasets: 3; Downregulated datasets: 1.
Survival by MTR expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MTR:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MTR | 4548 | 10 | 1 | 19 | |
| GSE20123 | MTR | 4548 | 11 | 1 | 18 | |
| GSE43470 | MTR | 4548 | 8 | 1 | 34 | |
| GSE46452 | MTR | 4548 | 4 | 2 | 53 | |
| GSE47630 | MTR | 4548 | 15 | 0 | 25 | |
| GSE54993 | MTR | 4548 | 0 | 6 | 64 | |
| GSE54994 | MTR | 4548 | 16 | 0 | 37 | |
| GSE60625 | MTR | 4548 | 0 | 0 | 11 | |
| GSE74703 | MTR | 4548 | 8 | 1 | 27 | |
| GSE74704 | MTR | 4548 | 4 | 0 | 16 | |
| TCGA | MTR | 4548 | 43 | 4 | 49 |
Total number of gains: 119; Total number of losses: 16; Total Number of normals: 353.
Somatic mutations of MTR:
Generating mutation plots.
Highly correlated genes for MTR:
Showing top 20/788 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MTR | SAT2 | 0.736352 | 3 | 0 | 3 |
| MTR | MRFAP1 | 0.722907 | 3 | 0 | 3 |
| MTR | CDKN1C | 0.69582 | 4 | 0 | 4 |
| MTR | C11orf95 | 0.675555 | 9 | 0 | 9 |
| MTR | SLC25A31 | 0.674562 | 3 | 0 | 3 |
| MTR | TMEM263 | 0.674098 | 6 | 0 | 6 |
| MTR | ZNF660 | 0.669963 | 3 | 0 | 3 |
| MTR | CNN1 | 0.664497 | 3 | 0 | 3 |
| MTR | MRGPRF | 0.664204 | 3 | 0 | 3 |
| MTR | C20orf194 | 0.657507 | 5 | 0 | 4 |
| MTR | PLBD2 | 0.649776 | 4 | 0 | 4 |
| MTR | VCAN | 0.648173 | 10 | 0 | 9 |
| MTR | JAZF1 | 0.647459 | 4 | 0 | 3 |
| MTR | KCNQ1OT1 | 0.641084 | 3 | 0 | 3 |
| MTR | SNAP47 | 0.64073 | 3 | 0 | 3 |
| MTR | RHOBTB1 | 0.639476 | 12 | 0 | 12 |
| MTR | MTERF3 | 0.639304 | 7 | 0 | 6 |
| MTR | TOMM40L | 0.637329 | 3 | 0 | 3 |
| MTR | LAMB1 | 0.635253 | 11 | 0 | 10 |
| MTR | LINC00674 | 0.635195 | 4 | 0 | 3 |
For details and further investigation, click here
