| Full name: KCNQ1 opposite strand/antisense transcript 1 | Alias Symbol: KvDMR1|KCNQ1-AS2|KvLQT1-AS|LIT1|NCRNA00012 | ||
| Type: non-coding RNA | Cytoband: 11p15.5 | ||
| Entrez ID: 10984 | HGNC ID: HGNC:6295 | Ensembl Gene: ENSG00000269821 | OMIM ID: 604115 |
| Drug and gene relationship at DGIdb | |||
Expression of KCNQ1OT1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KCNQ1OT1 | 10984 | 243435_at | 0.2861 | 0.7714 | |
| GSE26886 | KCNQ1OT1 | 10984 | 243435_at | 0.3975 | 0.0482 | |
| GSE45670 | KCNQ1OT1 | 10984 | 243435_at | 0.2288 | 0.4643 | |
| GSE53622 | KCNQ1OT1 | 10984 | 46550 | 0.4567 | 0.0053 | |
| GSE53624 | KCNQ1OT1 | 10984 | 46550 | 0.2800 | 0.0190 | |
| GSE63941 | KCNQ1OT1 | 10984 | 243435_at | -1.4565 | 0.0003 | |
| GSE77861 | KCNQ1OT1 | 10984 | 243435_at | 0.2378 | 0.1260 | |
| SRP007169 | KCNQ1OT1 | 10984 | RNAseq | 1.1131 | 0.0020 | |
| SRP008496 | KCNQ1OT1 | 10984 | RNAseq | 1.5101 | 0.0000 | |
| SRP064894 | KCNQ1OT1 | 10984 | RNAseq | -0.0350 | 0.8911 | |
| SRP133303 | KCNQ1OT1 | 10984 | RNAseq | 0.1676 | 0.2649 | |
| SRP159526 | KCNQ1OT1 | 10984 | RNAseq | 0.2320 | 0.5142 | |
| SRP193095 | KCNQ1OT1 | 10984 | RNAseq | 0.3348 | 0.0316 | |
| SRP219564 | KCNQ1OT1 | 10984 | RNAseq | 0.1241 | 0.7596 | |
| TCGA | KCNQ1OT1 | 10984 | RNAseq | -0.4555 | 0.0002 |
Upregulated datasets: 2; Downregulated datasets: 1.
Survival by KCNQ1OT1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of KCNQ1OT1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KCNQ1OT1 | 10984 | 1 | 11 | 18 | |
| GSE20123 | KCNQ1OT1 | 10984 | 1 | 12 | 17 | |
| GSE43470 | KCNQ1OT1 | 10984 | 1 | 10 | 32 | |
| GSE46452 | KCNQ1OT1 | 10984 | 7 | 8 | 44 | |
| GSE47630 | KCNQ1OT1 | 10984 | 4 | 12 | 24 | |
| GSE54993 | KCNQ1OT1 | 10984 | 3 | 1 | 66 | |
| GSE54994 | KCNQ1OT1 | 10984 | 1 | 12 | 40 | |
| GSE60625 | KCNQ1OT1 | 10984 | 0 | 0 | 11 | |
| GSE74703 | KCNQ1OT1 | 10984 | 1 | 8 | 27 | |
| GSE74704 | KCNQ1OT1 | 10984 | 0 | 8 | 12 | |
| TCGA | KCNQ1OT1 | 10984 | 8 | 39 | 49 |
Total number of gains: 27; Total number of losses: 121; Total Number of normals: 340.
Somatic mutations of KCNQ1OT1:
Generating mutation plots.
Highly correlated genes for KCNQ1OT1:
Showing top 20/122 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KCNQ1OT1 | USP2-AS1 | 0.823865 | 3 | 0 | 3 |
| KCNQ1OT1 | LEPROTL1 | 0.780619 | 3 | 0 | 3 |
| KCNQ1OT1 | ABCA9 | 0.773535 | 3 | 0 | 3 |
| KCNQ1OT1 | ZBED6 | 0.756689 | 3 | 0 | 3 |
| KCNQ1OT1 | MPPED1 | 0.732631 | 3 | 0 | 3 |
| KCNQ1OT1 | CD248 | 0.721493 | 3 | 0 | 3 |
| KCNQ1OT1 | SLC4A8 | 0.712042 | 3 | 0 | 3 |
| KCNQ1OT1 | SLC52A1 | 0.706768 | 3 | 0 | 3 |
| KCNQ1OT1 | SLC38A6 | 0.691394 | 4 | 0 | 4 |
| KCNQ1OT1 | RBM17 | 0.689701 | 3 | 0 | 3 |
| KCNQ1OT1 | KCP | 0.68941 | 3 | 0 | 3 |
| KCNQ1OT1 | DEFB126 | 0.687223 | 3 | 0 | 3 |
| KCNQ1OT1 | YJEFN3 | 0.683979 | 3 | 0 | 3 |
| KCNQ1OT1 | CDH11 | 0.68351 | 3 | 0 | 3 |
| KCNQ1OT1 | LZTS3 | 0.682856 | 3 | 0 | 3 |
| KCNQ1OT1 | MIRLET7BHG | 0.679635 | 4 | 0 | 4 |
| KCNQ1OT1 | ST8SIA1 | 0.679245 | 3 | 0 | 3 |
| KCNQ1OT1 | CD72 | 0.677884 | 3 | 0 | 3 |
| KCNQ1OT1 | SLC18A3 | 0.671929 | 3 | 0 | 3 |
| KCNQ1OT1 | FBRSL1 | 0.668771 | 4 | 0 | 4 |
For details and further investigation, click here
