| Full name: membrane metalloendopeptidase like 1 | Alias Symbol: SEP|NL1|NL2|NEPII | ||
| Type: protein-coding gene | Cytoband: 1p36.32 | ||
| Entrez ID: 79258 | HGNC ID: HGNC:14668 | Ensembl Gene: ENSG00000142606 | OMIM ID: 618104 |
| Drug and gene relationship at DGIdb | |||
Expression of MMEL1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MMEL1 | 79258 | 1552930_at | -0.6809 | 0.1947 | |
| GSE26886 | MMEL1 | 79258 | 1552930_at | -0.9694 | 0.0010 | |
| GSE45670 | MMEL1 | 79258 | 1552930_at | -0.8417 | 0.0084 | |
| GSE53622 | MMEL1 | 79258 | 9842 | -0.1910 | 0.0354 | |
| GSE53624 | MMEL1 | 79258 | 9842 | -0.7137 | 0.0000 | |
| GSE63941 | MMEL1 | 79258 | 1552930_at | 0.3642 | 0.6002 | |
| GSE77861 | MMEL1 | 79258 | 1552930_at | -0.6013 | 0.0015 | |
| SRP007169 | MMEL1 | 79258 | RNAseq | -6.4733 | 0.0000 | |
| SRP064894 | MMEL1 | 79258 | RNAseq | -3.0660 | 0.0000 | |
| SRP133303 | MMEL1 | 79258 | RNAseq | -2.9004 | 0.0000 | |
| SRP159526 | MMEL1 | 79258 | RNAseq | -3.3758 | 0.0001 | |
| TCGA | MMEL1 | 79258 | RNAseq | -3.5167 | 0.0032 |
Upregulated datasets: 0; Downregulated datasets: 5.
Survival by MMEL1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MMEL1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MMEL1 | 79258 | 3 | 6 | 21 | |
| GSE20123 | MMEL1 | 79258 | 3 | 5 | 22 | |
| GSE43470 | MMEL1 | 79258 | 2 | 5 | 36 | |
| GSE46452 | MMEL1 | 79258 | 7 | 1 | 51 | |
| GSE47630 | MMEL1 | 79258 | 8 | 4 | 28 | |
| GSE54993 | MMEL1 | 79258 | 3 | 2 | 65 | |
| GSE54994 | MMEL1 | 79258 | 15 | 2 | 36 | |
| GSE60625 | MMEL1 | 79258 | 0 | 0 | 11 | |
| GSE74703 | MMEL1 | 79258 | 2 | 3 | 31 | |
| GSE74704 | MMEL1 | 79258 | 3 | 0 | 17 | |
| TCGA | MMEL1 | 79258 | 14 | 20 | 62 |
Total number of gains: 60; Total number of losses: 48; Total Number of normals: 380.
Somatic mutations of MMEL1:
Generating mutation plots.
Highly correlated genes for MMEL1:
Showing top 20/1031 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MMEL1 | SFTA2 | 0.832389 | 5 | 0 | 5 |
| MMEL1 | ACPP | 0.81776 | 4 | 0 | 4 |
| MMEL1 | SPNS2 | 0.80878 | 4 | 0 | 4 |
| MMEL1 | USP6NL | 0.805559 | 4 | 0 | 4 |
| MMEL1 | B3GNT8 | 0.805019 | 4 | 0 | 4 |
| MMEL1 | NCK2 | 0.803748 | 4 | 0 | 4 |
| MMEL1 | PADI1 | 0.800151 | 4 | 0 | 4 |
| MMEL1 | SYNPO2L | 0.799623 | 4 | 0 | 4 |
| MMEL1 | FRMD4B | 0.785932 | 4 | 0 | 4 |
| MMEL1 | ACER1 | 0.785217 | 4 | 0 | 4 |
| MMEL1 | ARHGAP10 | 0.783304 | 3 | 0 | 3 |
| MMEL1 | PIH1D2 | 0.782915 | 3 | 0 | 3 |
| MMEL1 | PDLIM5 | 0.782478 | 4 | 0 | 4 |
| MMEL1 | TPRG1 | 0.780914 | 4 | 0 | 4 |
| MMEL1 | BLNK | 0.77628 | 5 | 0 | 4 |
| MMEL1 | CLIC3 | 0.776009 | 4 | 0 | 4 |
| MMEL1 | ATP6V1C2 | 0.774409 | 4 | 0 | 4 |
| MMEL1 | DBNDD1 | 0.771325 | 4 | 0 | 4 |
| MMEL1 | VASN | 0.769194 | 4 | 0 | 4 |
| MMEL1 | MOSPD1 | 0.765338 | 4 | 0 | 4 |
For details and further investigation, click here
