| Full name: 5-hydroxytryptamine receptor 4 | Alias Symbol: 5-HT4 | ||
| Type: protein-coding gene | Cytoband: 5q32 | ||
| Entrez ID: 3360 | HGNC ID: HGNC:5299 | Ensembl Gene: ENSG00000164270 | OMIM ID: 602164 |
| Drug and gene relationship at DGIdb | |||
HTR4 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04020 | Calcium signaling pathway | |
| hsa04024 | cAMP signaling pathway | |
| hsa04726 | Serotonergic synapse |
Expression of HTR4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HTR4 | 3360 | 207578_s_at | -0.0159 | 0.9599 | |
| GSE20347 | HTR4 | 3360 | 207578_s_at | -0.2044 | 0.0474 | |
| GSE23400 | HTR4 | 3360 | 207578_s_at | -0.1905 | 0.0000 | |
| GSE26886 | HTR4 | 3360 | 207578_s_at | -0.0668 | 0.5851 | |
| GSE29001 | HTR4 | 3360 | 207578_s_at | -0.3279 | 0.0224 | |
| GSE38129 | HTR4 | 3360 | 207578_s_at | -0.2879 | 0.0529 | |
| GSE45670 | HTR4 | 3360 | 207578_s_at | 0.1046 | 0.1915 | |
| GSE53622 | HTR4 | 3360 | 124436 | -1.2875 | 0.0000 | |
| GSE53624 | HTR4 | 3360 | 124436 | -1.1615 | 0.0000 | |
| GSE63941 | HTR4 | 3360 | 207578_s_at | 0.4072 | 0.0143 | |
| GSE77861 | HTR4 | 3360 | 207578_s_at | -0.1112 | 0.3077 | |
| TCGA | HTR4 | 3360 | RNAseq | -2.6579 | 0.0012 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by HTR4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HTR4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HTR4 | 3360 | 1 | 12 | 17 | |
| GSE20123 | HTR4 | 3360 | 1 | 13 | 16 | |
| GSE43470 | HTR4 | 3360 | 2 | 9 | 32 | |
| GSE46452 | HTR4 | 3360 | 0 | 27 | 32 | |
| GSE47630 | HTR4 | 3360 | 0 | 20 | 20 | |
| GSE54993 | HTR4 | 3360 | 9 | 1 | 60 | |
| GSE54994 | HTR4 | 3360 | 2 | 15 | 36 | |
| GSE60625 | HTR4 | 3360 | 0 | 0 | 11 | |
| GSE74703 | HTR4 | 3360 | 2 | 7 | 27 | |
| GSE74704 | HTR4 | 3360 | 1 | 8 | 11 | |
| TCGA | HTR4 | 3360 | 5 | 38 | 53 |
Total number of gains: 23; Total number of losses: 150; Total Number of normals: 315.
Somatic mutations of HTR4:
Generating mutation plots.
Highly correlated genes for HTR4:
Showing top 20/1192 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HTR4 | DUX1 | 0.732085 | 5 | 0 | 5 |
| HTR4 | ACRV1 | 0.722251 | 6 | 0 | 6 |
| HTR4 | PIWIL2 | 0.708117 | 5 | 0 | 5 |
| HTR4 | RGR | 0.700802 | 5 | 0 | 4 |
| HTR4 | SCNN1G | 0.700564 | 5 | 0 | 5 |
| HTR4 | MVK | 0.699124 | 8 | 0 | 7 |
| HTR4 | ZNF835 | 0.694968 | 3 | 0 | 3 |
| HTR4 | OR2C1 | 0.694711 | 6 | 0 | 6 |
| HTR4 | MTAP | 0.69284 | 4 | 0 | 4 |
| HTR4 | KRT76 | 0.690953 | 5 | 0 | 5 |
| HTR4 | CBL | 0.689223 | 4 | 0 | 3 |
| HTR4 | IL9R | 0.689142 | 6 | 0 | 5 |
| HTR4 | GH2 | 0.688812 | 6 | 0 | 5 |
| HTR4 | BTN1A1 | 0.68307 | 6 | 0 | 6 |
| HTR4 | GRIN1 | 0.681539 | 6 | 0 | 5 |
| HTR4 | GNRH2 | 0.680587 | 6 | 0 | 5 |
| HTR4 | EVX1 | 0.679344 | 5 | 0 | 5 |
| HTR4 | SLC6A5 | 0.679203 | 4 | 0 | 4 |
| HTR4 | SEZ6L | 0.679161 | 4 | 0 | 4 |
| HTR4 | DRD2 | 0.676061 | 8 | 0 | 8 |
For details and further investigation, click here
