PLA2G4D

 

Full name: phospholipase A2 group IVD Alias Symbol: cPLA2delta
Type: protein-coding gene Cytoband: 15q14
Entrez ID: 283748 HGNC ID: HGNC:30038 Ensembl Gene: ENSG00000159337 OMIM ID: 612864
Drug and gene relationship at DGIdb

 

PLA2G4D involved pathways:

KEGG pathway Description View
hsa04010MAPK signaling pathway
hsa04014Ras signaling pathway
hsa04270Vascular smooth muscle contraction
hsa04370VEGF signaling pathway
hsa04611Platelet activation
hsa04664Fc epsilon RI signaling pathway
hsa04666Fc gamma R-mediated phagocytosis
hsa04724Glutamatergic synapse
hsa04726Serotonergic synapse
hsa04730Long-term depression
hsa04750Inflammatory mediator regulation of TRP channels
hsa04912GnRH signaling pathway
hsa04913Ovarian steroidogenesis
hsa04921Oxytocin signaling pathway
hsa05231Choline metabolism in cancer

 

Expression of PLA2G4D:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PLA2G4D 283748 1554914_at 0.0473 0.8796
GSE26886 PLA2G4D 283748 1554914_at -0.3115 0.0045
GSE45670 PLA2G4D 283748 1554914_at 0.0928 0.3964
GSE53622 PLA2G4D 283748 93792 -0.0362 0.8785
GSE53624 PLA2G4D 283748 93792 -0.6645 0.0001
GSE63941 PLA2G4D 283748 1554914_at 0.1521 0.3118
GSE77861 PLA2G4D 283748 1554914_at -0.0813 0.4921
GSE97050 PLA2G4D 283748 A_33_P3361611 0.0843 0.7777
SRP007169 PLA2G4D 283748 RNAseq -4.1232 0.0000
SRP133303 PLA2G4D 283748 RNAseq -0.1071 0.5697
SRP193095 PLA2G4D 283748 RNAseq -0.6431 0.0043
SRP219564 PLA2G4D 283748 RNAseq -1.1846 0.0415
TCGA PLA2G4D 283748 RNAseq 0.5889 0.2515

Upregulated datasets: 0; Downregulated datasets: 2.  

 

Survival by PLA2G4D expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PLA2G4D:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PLA2G4D 283748 4 5 21
GSE20123 PLA2G4D 283748 4 5 21
GSE43470 PLA2G4D 283748 4 5 34
GSE46452 PLA2G4D 283748 3 7 49
GSE47630 PLA2G4D 283748 8 11 21
GSE54993 PLA2G4D 283748 4 6 60
GSE54994 PLA2G4D 283748 5 7 41
GSE60625 PLA2G4D 283748 4 0 7
GSE74703 PLA2G4D 283748 4 4 28
GSE74704 PLA2G4D 283748 3 3 14
TCGA PLA2G4D 283748 11 17 68

Total number of gains: 54; Total number of losses: 70; Total Number of normals: 364.  

 

Somatic mutations of PLA2G4D:

 

Generating mutation plots.

 

Highly correlated genes for PLA2G4D:

 

Showing top 20/149 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PLA2G4DTMEM1010.761467303
PLA2G4DCRYGC0.742236303
PLA2G4DNCR30.738886303
PLA2G4DMFSD110.735054303
PLA2G4DABCC60.732009303
PLA2G4DLCE3E0.714864404
PLA2G4DSLC6A180.71389303
PLA2G4DARHGAP300.69642303
PLA2G4DMYL40.691776303
PLA2G4DTJP20.687111303
PLA2G4DSLC35F30.686005403
PLA2G4DSLC6A30.68054303
PLA2G4DMAPKAPK30.672677303
PLA2G4DUPB10.669815303
PLA2G4DC1orf610.669154303
PLA2G4DCCDC1570.661496303
PLA2G4DCYP2D60.657914303
PLA2G4DCRB20.657067303
PLA2G4DKIF26A0.656855403
PLA2G4DCDK5R20.651902303

For details and further investigation, click here