| Full name: myosin light chain kinase family member 4 | Alias Symbol: SgK085 | ||
| Type: protein-coding gene | Cytoband: 6p25.2 | ||
| Entrez ID: 340156 | HGNC ID: HGNC:27972 | Ensembl Gene: ENSG00000145949 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
MYLK4 involved pathways:
Expression of MYLK4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MYLK4 | 340156 | 1556136_at | 0.3673 | 0.6398 | |
| GSE26886 | MYLK4 | 340156 | 1556136_at | -0.6630 | 0.0005 | |
| GSE45670 | MYLK4 | 340156 | 1556136_at | 0.0781 | 0.7724 | |
| GSE53622 | MYLK4 | 340156 | 61056 | -0.5135 | 0.0051 | |
| GSE53624 | MYLK4 | 340156 | 61056 | -0.7280 | 0.0000 | |
| GSE63941 | MYLK4 | 340156 | 1561503_at | 0.0070 | 0.9745 | |
| GSE77861 | MYLK4 | 340156 | 1556136_at | -0.1169 | 0.2684 | |
| SRP133303 | MYLK4 | 340156 | RNAseq | -0.5133 | 0.0105 | |
| SRP159526 | MYLK4 | 340156 | RNAseq | -0.9279 | 0.0207 | |
| SRP193095 | MYLK4 | 340156 | RNAseq | -0.4022 | 0.0191 | |
| SRP219564 | MYLK4 | 340156 | RNAseq | -0.4544 | 0.4911 | |
| TCGA | MYLK4 | 340156 | RNAseq | 0.1422 | 0.4777 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by MYLK4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MYLK4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MYLK4 | 340156 | 4 | 5 | 21 | |
| GSE20123 | MYLK4 | 340156 | 4 | 5 | 21 | |
| GSE43470 | MYLK4 | 340156 | 9 | 4 | 30 | |
| GSE46452 | MYLK4 | 340156 | 1 | 10 | 48 | |
| GSE47630 | MYLK4 | 340156 | 7 | 8 | 25 | |
| GSE54993 | MYLK4 | 340156 | 1 | 1 | 68 | |
| GSE54994 | MYLK4 | 340156 | 10 | 3 | 40 | |
| GSE60625 | MYLK4 | 340156 | 0 | 1 | 10 | |
| GSE74703 | MYLK4 | 340156 | 8 | 3 | 25 | |
| GSE74704 | MYLK4 | 340156 | 2 | 2 | 16 | |
| TCGA | MYLK4 | 340156 | 17 | 30 | 49 |
Total number of gains: 63; Total number of losses: 72; Total Number of normals: 353.
Somatic mutations of MYLK4:
Generating mutation plots.
Highly correlated genes for MYLK4:
Showing top 20/58 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MYLK4 | LINC00852 | 0.729343 | 3 | 0 | 3 |
| MYLK4 | KIAA0556 | 0.69194 | 3 | 0 | 3 |
| MYLK4 | CCSER2 | 0.660739 | 3 | 0 | 3 |
| MYLK4 | AKR7A3 | 0.659327 | 3 | 0 | 3 |
| MYLK4 | SHQ1 | 0.644905 | 4 | 0 | 4 |
| MYLK4 | OXNAD1 | 0.636723 | 3 | 0 | 3 |
| MYLK4 | TMEM217 | 0.635558 | 3 | 0 | 3 |
| MYLK4 | TBC1D22B | 0.634684 | 5 | 0 | 4 |
| MYLK4 | SLC39A2 | 0.628041 | 3 | 0 | 3 |
| MYLK4 | BAG6 | 0.623526 | 3 | 0 | 3 |
| MYLK4 | MAEL | 0.62212 | 3 | 0 | 3 |
| MYLK4 | SCGB1A1 | 0.607973 | 3 | 0 | 3 |
| MYLK4 | SNIP1 | 0.607528 | 3 | 0 | 3 |
| MYLK4 | GPBP1L1 | 0.603714 | 4 | 0 | 3 |
| MYLK4 | PDE6A | 0.595359 | 3 | 0 | 3 |
| MYLK4 | LY6G6C | 0.594877 | 3 | 0 | 3 |
| MYLK4 | MAPK13 | 0.594156 | 4 | 0 | 3 |
| MYLK4 | MBNL3 | 0.594103 | 4 | 0 | 3 |
| MYLK4 | PARD6B | 0.591072 | 3 | 0 | 3 |
| MYLK4 | VILL | 0.590589 | 3 | 0 | 3 |
For details and further investigation, click here
