MAPK13

 

Full name: mitogen-activated protein kinase 13 Alias Symbol: SAPK4|p38delta
Type: protein-coding gene Cytoband: 6p21.31
Entrez ID: 5603 HGNC ID: HGNC:6875 Ensembl Gene: ENSG00000156711 OMIM ID: 602899
Drug and gene relationship at DGIdb

 

MAPK13 involved pathways:

KEGG pathway Description View
hsa04010MAPK signaling pathway
hsa04015Rap1 signaling pathway
hsa04068FoxO signaling pathway
hsa04071Sphingolipid signaling pathway
hsa04261Adrenergic signaling in cardiomyocytes
hsa04370VEGF signaling pathway
hsa04380Osteoclast differentiation
hsa04550Signaling pathways regulating pluripotency of stem cells
hsa04611Platelet activation
hsa04620Toll-like receptor signaling pathway
hsa04621NOD-like receptor signaling pathway
hsa04622RIG-I-like receptor signaling pathway
hsa04660T cell receptor signaling pathway
hsa04664Fc epsilon RI signaling pathway
hsa04668TNF signaling pathway
hsa04670Leukocyte transendothelial migration
hsa04722Neurotrophin signaling pathway
hsa04723Retrograde endocannabinoid signaling
hsa04728Dopaminergic synapse
hsa04750Inflammatory mediator regulation of TRP channels
hsa04912GnRH signaling pathway
hsa04914Progesterone-mediated oocyte maturation
hsa04917Prolactin signaling pathway
hsa04933AGE-RAGE signaling pathway in diabetic complications
hsa05014Amyotrophic lateral sclerosis (ALS)
hsa05120Epithelial cell signaling in Helicobacter pylori infection
hsa05131Shigellosis
hsa05132Salmonella infection
hsa05133Pertussis
hsa05140Leishmaniasis
hsa05142Chagas disease (American trypanosomiasis)
hsa05145Toxoplasmosis
hsa05152Tuberculosis
hsa05160Hepatitis C
hsa05164Influenza A
hsa05169Epstein-Barr virus infection
hsa05205Proteoglycans in cancer

 

Expression of MAPK13:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 MAPK13 5603 210058_at -0.0413 0.9740
GSE20347 MAPK13 5603 210058_at -1.3545 0.0000
GSE23400 MAPK13 5603 210058_at -0.5935 0.0000
GSE26886 MAPK13 5603 210059_s_at -1.8261 0.0000
GSE29001 MAPK13 5603 210059_s_at -0.9931 0.0023
GSE38129 MAPK13 5603 210058_at -0.3571 0.4299
GSE45670 MAPK13 5603 210058_at -0.3051 0.1621
GSE53622 MAPK13 5603 127674 -0.6853 0.0000
GSE53624 MAPK13 5603 127674 -0.9439 0.0000
GSE63941 MAPK13 5603 210058_at 2.0578 0.0400
GSE77861 MAPK13 5603 210058_at -1.1728 0.0011
GSE97050 MAPK13 5603 A_23_P145376 0.1593 0.7337
SRP007169 MAPK13 5603 RNAseq -1.8706 0.0000
SRP008496 MAPK13 5603 RNAseq -1.7858 0.0000
SRP064894 MAPK13 5603 RNAseq -0.8290 0.0021
SRP133303 MAPK13 5603 RNAseq -1.0046 0.0000
SRP159526 MAPK13 5603 RNAseq -0.8722 0.0276
SRP193095 MAPK13 5603 RNAseq -0.9737 0.0000
SRP219564 MAPK13 5603 RNAseq -1.2566 0.0930
TCGA MAPK13 5603 RNAseq 0.1828 0.0349

Upregulated datasets: 1; Downregulated datasets: 6.  

 

Survival by MAPK13 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of MAPK13:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 MAPK13 5603 5 0 25
GSE20123 MAPK13 5603 5 0 25
GSE43470 MAPK13 5603 5 1 37
GSE46452 MAPK13 5603 2 9 48
GSE47630 MAPK13 5603 8 4 28
GSE54993 MAPK13 5603 3 1 66
GSE54994 MAPK13 5603 11 4 38
GSE60625 MAPK13 5603 1 0 10
GSE74703 MAPK13 5603 5 0 31
GSE74704 MAPK13 5603 2 0 18
TCGA MAPK13 5603 15 15 66

Total number of gains: 62; Total number of losses: 34; Total Number of normals: 392.  

 

Somatic mutations of MAPK13:

 

Generating mutation plots.

 

Highly correlated genes for MAPK13:

 

Showing top 20/1024 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
MAPK13SNORA680.860174303
MAPK13VSIG10L0.81272606
MAPK13NCCRP10.808831303
MAPK13EPS8L20.79808711011
MAPK13TGM10.796247909
MAPK13RAB250.79227312011
MAPK13EVPL0.78828612012
MAPK13RAET1E0.786306706
MAPK13FAM163B0.782121303
MAPK13TMEM184A0.779917303
MAPK13MFSD2B0.775959303
MAPK13SDCBP20.769785303
MAPK13SPNS20.769416404
MAPK13EVPLL0.764121505
MAPK13MAL20.762792808
MAPK13TEN10.760625303
MAPK13RASSF50.759851606
MAPK13C15orf480.757691707
MAPK13NUDT80.757243303
MAPK13IL1RN0.75592511010

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