| Full name: phosphodiesterase 6A | Alias Symbol: RP43 | ||
| Type: protein-coding gene | Cytoband: 5q32 | ||
| Entrez ID: 5145 | HGNC ID: HGNC:8785 | Ensembl Gene: ENSG00000132915 | OMIM ID: 180071 |
| Drug and gene relationship at DGIdb | |||
Expression of PDE6A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PDE6A | 5145 | 206623_at | -0.7211 | 0.0369 | |
| GSE20347 | PDE6A | 5145 | 206623_at | -0.4513 | 0.0003 | |
| GSE23400 | PDE6A | 5145 | 206623_at | -0.2311 | 0.0000 | |
| GSE26886 | PDE6A | 5145 | 206623_at | -0.8304 | 0.0015 | |
| GSE29001 | PDE6A | 5145 | 206623_at | -0.3323 | 0.0189 | |
| GSE38129 | PDE6A | 5145 | 206623_at | -0.4550 | 0.0014 | |
| GSE45670 | PDE6A | 5145 | 206623_at | -0.4843 | 0.0056 | |
| GSE53622 | PDE6A | 5145 | 26644 | -1.8501 | 0.0000 | |
| GSE53624 | PDE6A | 5145 | 26644 | -2.1554 | 0.0000 | |
| GSE63941 | PDE6A | 5145 | 206623_at | 0.3296 | 0.0261 | |
| GSE77861 | PDE6A | 5145 | 206623_at | -0.1447 | 0.1239 | |
| SRP007169 | PDE6A | 5145 | RNAseq | -2.5870 | 0.0000 | |
| SRP064894 | PDE6A | 5145 | RNAseq | -0.9961 | 0.0000 | |
| SRP133303 | PDE6A | 5145 | RNAseq | -0.2395 | 0.0066 | |
| SRP159526 | PDE6A | 5145 | RNAseq | -1.2278 | 0.0005 | |
| SRP193095 | PDE6A | 5145 | RNAseq | -0.3956 | 0.0036 | |
| SRP219564 | PDE6A | 5145 | RNAseq | -0.5386 | 0.3668 | |
| TCGA | PDE6A | 5145 | RNAseq | -0.3724 | 0.4875 |
Upregulated datasets: 0; Downregulated datasets: 4.
Survival by PDE6A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PDE6A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PDE6A | 5145 | 1 | 12 | 17 | |
| GSE20123 | PDE6A | 5145 | 1 | 12 | 17 | |
| GSE43470 | PDE6A | 5145 | 1 | 10 | 32 | |
| GSE46452 | PDE6A | 5145 | 0 | 27 | 32 | |
| GSE47630 | PDE6A | 5145 | 0 | 20 | 20 | |
| GSE54993 | PDE6A | 5145 | 9 | 1 | 60 | |
| GSE54994 | PDE6A | 5145 | 2 | 15 | 36 | |
| GSE60625 | PDE6A | 5145 | 0 | 0 | 11 | |
| GSE74703 | PDE6A | 5145 | 1 | 7 | 28 | |
| GSE74704 | PDE6A | 5145 | 1 | 7 | 12 | |
| TCGA | PDE6A | 5145 | 5 | 38 | 53 |
Total number of gains: 21; Total number of losses: 149; Total Number of normals: 318.
Somatic mutations of PDE6A:
Generating mutation plots.
Highly correlated genes for PDE6A:
Showing top 20/1276 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PDE6A | KRT32 | 0.727013 | 10 | 0 | 10 |
| PDE6A | MYCN | 0.715206 | 4 | 0 | 4 |
| PDE6A | SFTA2 | 0.713762 | 4 | 0 | 4 |
| PDE6A | TFAP2B | 0.707293 | 10 | 0 | 10 |
| PDE6A | SLC46A2 | 0.70657 | 6 | 0 | 6 |
| PDE6A | ASPG | 0.697631 | 5 | 0 | 5 |
| PDE6A | DLG2 | 0.693944 | 9 | 0 | 9 |
| PDE6A | SMIM5 | 0.692584 | 6 | 0 | 6 |
| PDE6A | TMEM61 | 0.691112 | 3 | 0 | 3 |
| PDE6A | HCG22 | 0.685962 | 7 | 0 | 7 |
| PDE6A | BNIPL | 0.684517 | 6 | 0 | 6 |
| PDE6A | SAMD5 | 0.683886 | 6 | 0 | 5 |
| PDE6A | FCHO2 | 0.681237 | 6 | 0 | 6 |
| PDE6A | NOXA1 | 0.680958 | 4 | 0 | 4 |
| PDE6A | DEGS2 | 0.679016 | 6 | 0 | 6 |
| PDE6A | BBOX1 | 0.678437 | 9 | 0 | 9 |
| PDE6A | RAET1E | 0.677736 | 6 | 0 | 6 |
| PDE6A | SCNN1B | 0.675395 | 10 | 0 | 9 |
| PDE6A | LINC00330 | 0.671982 | 6 | 0 | 6 |
| PDE6A | AGFG2 | 0.670931 | 9 | 0 | 9 |
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