| Full name: NEDD8 activating enzyme E1 subunit 1 | Alias Symbol: ula-1|APP-BP1 | ||
| Type: protein-coding gene | Cytoband: 16q22.1 | ||
| Entrez ID: 8883 | HGNC ID: HGNC:621 | Ensembl Gene: ENSG00000159593 | OMIM ID: 603385 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
NAE1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05010 | Alzheimer's disease |
Expression of NAE1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NAE1 | 8883 | 202268_s_at | 0.1883 | 0.5002 | |
| GSE20347 | NAE1 | 8883 | 202268_s_at | 0.6116 | 0.0004 | |
| GSE23400 | NAE1 | 8883 | 202268_s_at | 0.5632 | 0.0000 | |
| GSE26886 | NAE1 | 8883 | 202268_s_at | 0.0288 | 0.9280 | |
| GSE29001 | NAE1 | 8883 | 202268_s_at | 0.3519 | 0.1815 | |
| GSE38129 | NAE1 | 8883 | 202268_s_at | 0.6575 | 0.0000 | |
| GSE45670 | NAE1 | 8883 | 202268_s_at | 0.1161 | 0.3179 | |
| GSE53622 | NAE1 | 8883 | 135496 | 0.2243 | 0.0007 | |
| GSE53624 | NAE1 | 8883 | 135496 | 0.3264 | 0.0000 | |
| GSE63941 | NAE1 | 8883 | 202268_s_at | 0.3604 | 0.2806 | |
| GSE77861 | NAE1 | 8883 | 202268_s_at | 0.3708 | 0.1379 | |
| GSE97050 | NAE1 | 8883 | A_23_P77459 | 0.1242 | 0.5981 | |
| SRP007169 | NAE1 | 8883 | RNAseq | -0.2382 | 0.5140 | |
| SRP008496 | NAE1 | 8883 | RNAseq | 0.1266 | 0.6255 | |
| SRP064894 | NAE1 | 8883 | RNAseq | -0.1087 | 0.4959 | |
| SRP133303 | NAE1 | 8883 | RNAseq | 0.5206 | 0.0018 | |
| SRP159526 | NAE1 | 8883 | RNAseq | 0.6186 | 0.0063 | |
| SRP193095 | NAE1 | 8883 | RNAseq | 0.1876 | 0.1548 | |
| SRP219564 | NAE1 | 8883 | RNAseq | -0.1514 | 0.5586 | |
| TCGA | NAE1 | 8883 | RNAseq | 0.2518 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by NAE1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NAE1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NAE1 | 8883 | 8 | 2 | 20 | |
| GSE20123 | NAE1 | 8883 | 8 | 2 | 20 | |
| GSE43470 | NAE1 | 8883 | 1 | 8 | 34 | |
| GSE46452 | NAE1 | 8883 | 38 | 1 | 20 | |
| GSE47630 | NAE1 | 8883 | 10 | 8 | 22 | |
| GSE54993 | NAE1 | 8883 | 2 | 4 | 64 | |
| GSE54994 | NAE1 | 8883 | 8 | 10 | 35 | |
| GSE60625 | NAE1 | 8883 | 4 | 0 | 7 | |
| GSE74703 | NAE1 | 8883 | 1 | 5 | 30 | |
| GSE74704 | NAE1 | 8883 | 5 | 1 | 14 | |
| TCGA | NAE1 | 8883 | 32 | 11 | 53 |
Total number of gains: 117; Total number of losses: 52; Total Number of normals: 319.
Somatic mutations of NAE1:
Generating mutation plots.
Highly correlated genes for NAE1:
Showing top 20/1276 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NAE1 | ANKRD13C | 0.802808 | 3 | 0 | 3 |
| NAE1 | CERK | 0.761698 | 3 | 0 | 3 |
| NAE1 | SLC30A7 | 0.757728 | 3 | 0 | 3 |
| NAE1 | ATP6V1B2 | 0.751211 | 3 | 0 | 3 |
| NAE1 | TTC39C | 0.741714 | 3 | 0 | 3 |
| NAE1 | MBTPS2 | 0.726461 | 4 | 0 | 3 |
| NAE1 | NAA15 | 0.722234 | 3 | 0 | 3 |
| NAE1 | CEP44 | 0.717633 | 3 | 0 | 3 |
| NAE1 | HAUS1 | 0.713257 | 3 | 0 | 3 |
| NAE1 | SS18L1 | 0.710642 | 4 | 0 | 3 |
| NAE1 | WIPF2 | 0.702277 | 4 | 0 | 4 |
| NAE1 | XPO7 | 0.700699 | 4 | 0 | 3 |
| NAE1 | ORC2 | 0.700098 | 6 | 0 | 6 |
| NAE1 | SDHAF2 | 0.698924 | 4 | 0 | 3 |
| NAE1 | ILF3 | 0.697979 | 8 | 0 | 8 |
| NAE1 | LIG3 | 0.695229 | 4 | 0 | 4 |
| NAE1 | INTS10 | 0.694346 | 5 | 0 | 3 |
| NAE1 | TP53RK | 0.690641 | 3 | 0 | 3 |
| NAE1 | TPRA1 | 0.69004 | 3 | 0 | 3 |
| NAE1 | PTPN14 | 0.688043 | 4 | 0 | 4 |
For details and further investigation, click here
