| Full name: origin recognition complex subunit 2 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 2q33.1 | ||
| Entrez ID: 4999 | HGNC ID: HGNC:8488 | Ensembl Gene: ENSG00000115942 | OMIM ID: 601182 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
ORC2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04110 | Cell cycle |
Expression of ORC2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ORC2 | 4999 | 204853_at | 0.7020 | 0.0920 | |
| GSE20347 | ORC2 | 4999 | 204853_at | 0.5638 | 0.0094 | |
| GSE23400 | ORC2 | 4999 | 204853_at | 0.5834 | 0.0000 | |
| GSE26886 | ORC2 | 4999 | 204853_at | -0.0704 | 0.8403 | |
| GSE29001 | ORC2 | 4999 | 204853_at | 0.4166 | 0.0345 | |
| GSE38129 | ORC2 | 4999 | 204853_at | 0.8797 | 0.0000 | |
| GSE45670 | ORC2 | 4999 | 204853_at | 0.3890 | 0.0578 | |
| GSE53622 | ORC2 | 4999 | 88620 | 0.1341 | 0.0656 | |
| GSE53624 | ORC2 | 4999 | 88620 | 0.1755 | 0.0100 | |
| GSE63941 | ORC2 | 4999 | 204853_at | 0.4674 | 0.1918 | |
| GSE77861 | ORC2 | 4999 | 204853_at | 0.3218 | 0.0504 | |
| GSE97050 | ORC2 | 4999 | A_23_P39616 | 0.2124 | 0.2994 | |
| SRP007169 | ORC2 | 4999 | RNAseq | 0.6310 | 0.1206 | |
| SRP008496 | ORC2 | 4999 | RNAseq | 0.7855 | 0.0023 | |
| SRP064894 | ORC2 | 4999 | RNAseq | 0.0440 | 0.8139 | |
| SRP133303 | ORC2 | 4999 | RNAseq | 0.1428 | 0.2457 | |
| SRP159526 | ORC2 | 4999 | RNAseq | 0.1529 | 0.4146 | |
| SRP193095 | ORC2 | 4999 | RNAseq | 0.0388 | 0.6344 | |
| SRP219564 | ORC2 | 4999 | RNAseq | 0.0152 | 0.9600 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by ORC2 expression:
 |  |
| GSE53622 | GSE53624 |
Note: Click image to view full size file.
Copy number change of ORC2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ORC2 | 4999 | 6 | 4 | 20 | |
| GSE20123 | ORC2 | 4999 | 6 | 4 | 20 | |
| GSE43470 | ORC2 | 4999 | 2 | 1 | 40 | |
| GSE46452 | ORC2 | 4999 | 1 | 4 | 54 | |
| GSE47630 | ORC2 | 4999 | 4 | 5 | 31 | |
| GSE54993 | ORC2 | 4999 | 0 | 3 | 67 | |
| GSE54994 | ORC2 | 4999 | 10 | 8 | 35 | |
| GSE60625 | ORC2 | 4999 | 0 | 3 | 8 | |
| GSE74703 | ORC2 | 4999 | 2 | 1 | 33 | |
| GSE74704 | ORC2 | 4999 | 3 | 2 | 15 | |
| TCGA | ORC2 | 4999 | 22 | 11 | 63 |
Total number of gains: 56; Total number of losses: 46; Total Number of normals: 386.
Somatic mutations of ORC2:
Generating mutation plots.
Highly correlated genes for ORC2:
Showing top 20/1225 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ORC2 | CCM2 | 0.825997 | 3 | 0 | 3 |
| ORC2 | KRTCAP2 | 0.807438 | 3 | 0 | 3 |
| ORC2 | UHMK1 | 0.798773 | 3 | 0 | 3 |
| ORC2 | CCDC127 | 0.797952 | 3 | 0 | 3 |
| ORC2 | COMMD5 | 0.795966 | 3 | 0 | 3 |
| ORC2 | SOCS7 | 0.788201 | 3 | 0 | 3 |
| ORC2 | SLC41A1 | 0.784912 | 3 | 0 | 3 |
| ORC2 | NUFIP2 | 0.779355 | 3 | 0 | 3 |
| ORC2 | RNF4 | 0.774687 | 3 | 0 | 3 |
| ORC2 | TEP1 | 0.774327 | 3 | 0 | 3 |
| ORC2 | UTP23 | 0.769341 | 3 | 0 | 3 |
| ORC2 | DHX37 | 0.763361 | 3 | 0 | 3 |
| ORC2 | ZNF284 | 0.755665 | 3 | 0 | 3 |
| ORC2 | VANGL2 | 0.744282 | 3 | 0 | 3 |
| ORC2 | EEF1D | 0.737606 | 4 | 0 | 4 |
| ORC2 | PUM1 | 0.736998 | 3 | 0 | 3 |
| ORC2 | WDR59 | 0.736271 | 3 | 0 | 3 |
| ORC2 | DDX55 | 0.734542 | 4 | 0 | 3 |
| ORC2 | ZNF251 | 0.730724 | 3 | 0 | 3 |
| ORC2 | FARS2 | 0.726363 | 3 | 0 | 3 |
For details and further investigation, click here
